a PhD position in the SSP group (CIFRE scholarship with SANOFI)

We are looking for a Physicochemist, with experimentation skills, to join our group for a PhD project starting the academic year 2019/2020.

Title : Microfluidic approaches to crystallize different phases of an Active Pharmaceutical Ingredient

Short abstract:

In pharmaceutical applications, a wide variety of solid forms may appear, such as polymorphs, solvates, microcrystalline solids, and amorphs. Here, we propose to study the impact of parameters, such as temperature, solute concentration and chemical composition on the solid form obtained using microfluidic setups1,2.

For more information :

Stéphane Veesler

Aix-Marseille Université, CNRS, CINaM UMR 7325, 13288 Marseille, France;

Email:, veesler@cinam.univ-mrs.fr

http://www.cinam.univ-mrs.fr/cinam/en/nucleation-and-crystallization-controlled-in-confined-environments/

References:

  1. Candoni, N.; Grossier, R.; Lagaize, M.; Veesler, S., Advances in the Use of Microfluidics to Study Crystallization Fundamentals. Annual Review of Chemical and Biomolecular Engineering 2019, 10 (1), 59-83. https://www.annualreviews.org/doi/full/10.1146/annurev-chembioeng-060718-030312
  2. Grossier, R.; Tishkova, V.; Morin, R.; Veesler, S., A parameter to probe microdroplet dynamics and crystal nucleation. AIP Advances 2018, 8 (7), 075324. https://aip.scitation.org/doi/abs/10.1063/1.5034443