Romain Grossier

Axe

Sources et Sondes Ponctuelles

E-mail

romain.grossier@cnrs.fr

Phone

+33(0)6 62 92 28 79

Localisation

R3

Grade

CRCN

Fonction

chercheur

grossier.jpg

Activity

Nucleation / Crystallization / Microfluidics / Optical Microscopy / Image Processing

Thèmes

Milieu confiné

Nucléation

 

Publications

2023

CNT effective interfacial energy and pre-exponential kinetic factor from measured NaCl crystal nucleation time distributions in contracting microdroplets

Ruel Cedeno, Romain Grossier, Nadine Candoni, Nicolas Levernier, Adrian Flood, Stéphane Veesler

Journal of Chemical Physics 158:194705 (2023)10.1063/5.0143704

Microdroplet Approach for Measuring Aqueous Solubility and Nucleation Kinetics of a Metastable Polymorph: The case of KDP Phase IV

Ruel Cedeno, Romain Grossier, Nadine Candoni, Stéphane Veesler

Crystal Growth & Design (2023)

Modular microfluidic platform for solubility measurement, nucleation statistics and polymorph screening of active pharmaceutical ingredients: Irbesartan, Rimonabant, Aripiprazole and Sulfathiazole

Mathilde Lambert, Romain Grossier, Mehdi Lagaize, Thirou Bactivelane, Vasile Heresanu, Benoît Robert, Nadine Candoni, Stéphane Veesler

Journal of Crystal Growth 616:127252 (2023)

2022

Evaporation Dynamics of Sessile Saline Microdroplets in Oil

Ruel Cedeno, Romain Grossier, Victoria Tishkova, Nadine Candoni, Adrian E. Flood, Stéphane Veesler

Langmuir 38:9686-9696 (2022)10.1021/acs.langmuir.2c01269

Nucleation in Sessile Saline Microdroplets: Induction Time Measurement via Deliquescence-Recrystallization Cycling

Ruel Cedeno, Romain A Grossier, Mehdi Lagaize, D. Nerini, Nadine Candoni, A. E. Flood, Stéphane Veesler

Faraday Discussions 183-197 (2022)10.1039/D1FD00090J

2021

2020

Microfluidics platform for polymorph screening directly from powder

Guillem Peybernès, Romain Grossier, Frédéric Villard, Philippe Letellier, Nadine Candoni, Stéphane Veesler

Crystal Growth & Design 20:3882-3887 (2020)

A microfluidic method generating monodispersed microparticles with controllable sizes and mechanical properties

Cheng Zhang, Romain A Grossier, Leda Lacaria, Felix Rico, Nadine A Candoni, Stéphane A Veesler

Chemical Engineering Science 211:115322 (2020)10.1016/j.ces.2019.115322

2019

Advances in the Use of Microfluidics to Study Crystallization Fundamentals

Nadine A Candoni, Romain Grossier, Mehdi Lagaize, Stéphane Veesler

Annual Review of Chemical and Biomolecular Engineering 10:59-83 (2019)10.1146/annurev-chembioeng-060718-030312

2018

A chemical library to screen protein and protein-ligand crystallization using a versatile microfluidic platform

Charline J. J. Gerard, Gilles Ferry, Laurent M Vuillard, Jean A. Boutin, Nathalie A Ferte, Romain A Grossier, Nadine A Candoni, Stéphane A Veesler

Crystal Growth & Design 18:5130-5137 (2018)10.1021/acs.cgd.8b00572

A parameter to probe microdroplet dynamics and crystal nucleation

R. Grossier, Victoria Tishkova, R. Morin, S. Veesler

AIP Advances 8:075324 (2018)10.1063/1.5034443

Microfluidics set-up rapidly measures solubility directly from powder

Guillem Peybernès, Romain A Grossier, Frédéric Villard, Philippe Letellier, Mehdi Lagaize, Nadine A Candoni, Stéphane Veesler

Organic Process Research and Development 22:1856-1860 (2018)10.1021/acs.oprd.8b00300

2017

Crystallization via tubing microfluidics permits both in situ and ex situ X-ray diffraction

Charline J. J. Gerard, Gilles Ferry, Laurent M Vuillard, Jean A Boutin, Léonard M.G. Chavas, Tiphaine Huet, Nathalie A Ferte, Romain A Grossier, Nadine Candoni, Stéphane Veesler

Acta crystallographica Section F : Structural biology communications [2014-...] 73:574-578 (2017)10.1107/S2053230X17013826

Microfluidic platform for optimization of crystallization conditions

Shuheng A Zhang, Charline J. J. Gerard, Aziza A Ikni, Gilles Ferry, Laurent M Vuillard, Jean A. Boutin, Nathalie A Ferte, Romain A Grossier, Nadine A Candoni, Stéphane A Veesler

Journal of Crystal Growth 472:18-28 (2017)10.1016/j.jcrysgro.2017.01.026

2015

Localizing and inducing primary nucleation

Z. Hammadi, R. Grossier, Aziza Ikni, N. Candoni, R. Morin, S. Veesler

Faraday Discussions 179:489-501 (2015)10.1039/c4fd00274a

2013

Small-volumes nucleation

Z. Hammadi, N. Candoni, R. Grossier, Manuel Ildefonso, R. Morin, S. Veesler

Comptes Rendus. Physique 14:192-198 (2013)

Small-volume nucleation

Zoubida Hammadi, Nadine Candoni, Romain Grossier, Manuel Ildefonso, Roger Morin, Stéphane Veesler

Comptes Rendus. Physique 14:192-198 (2013)10.1016/j.crhy.2012.12.004

Monitoring Picoliter Sessile Microdroplet Dynamics Shows That Size Does Not Matter

I. Rodriguez-Ruiz, Z. Hammadi, R. Grossier, J. Gomez-Morales, S. Veesler

Langmuir 29:12628-12632 (2013)10.1021/la402735k

2012

Nanotechnologies dedicated to nucleation control

N. Candoni, R. Grossier, Manuel Ildefonso, E. Revalor, N. Ferté, T. Okutsu, R. Morin, S. Veesler

International Journal of Nanotechnology 9:439-459 (2012)

Practical Physics Behind Growing Crystals of Biological Macromolecules

N. Candoni, R. Grossier, Z. Hammadi, R. Morin, S. Veesler

Protein and Peptide Letters 19:714-724 (2012)

2011

Generating nanoliter to femtoliter microdroplets with ease

R. Grossier, Z. Hammadi, R. Morin, A. Magnaldo, S. Veesler

Applied Physics Letters 98:091916-3 (2011)

Predictive nucleation of Crystals in Small Volumes and Its Consequences

R. Grossier, Z. Hammadi, R. Morin, S. Veesler

Physical Review Letters 107:025504 (2011)

2010

Ultra-fast crystallization due to Confinement

R. Grossier, A. Magnaldo, S. Veesler

Journal of Crystal Growth 312:487-489 (2010)

Usual and Unusual Crystallization from Solution

E. Revalor, Z. Hammadi, J.P. Astier, R. Grossier, E. Garcia, C. Hoff, K. Furuta, T. Okutsu, R. Morin, S. Veesler

Journal of Crystal Growth 312:939-946 (2010)

2009

Reaching one single and stable critical cluster through finite sized systems

R. Grossier, S. Veesler

Crystal Growth & Design 9:1917-1922 (2009)

2007

The effect of ultrasound on crystallization-precipitation processes : some examples and a new segregation model

John A. Dodds, Fabienne Espitalier, Olivier Louisnard, Romain Grossier, René David, Myriam Hassoun, Fabien Baillon, Cendrine Gatumel, Nathalie Lyczko

Particle & Particle Systems Characterization 24:p.18-28 (2007)10.1002/ppsc.200601046

Mixture segregation by an inertial cavitation bubble

R. Grossier, Olivier Louisnard, Y. Vargas

Ultrasonics Sonochemistry 14:431-437 (2007)10.1016/j.ultsonch.2006.10.010

Segregation of a liquid mixture by a radially oscillating bubble

Olivier Louisnard, Francisco J. Gomez, Romain Grossier

Journal of Fluid Mechanics 577:385-415 (2007)10.1017/S002211200700479X