Wenjun Lan
TPR1 - 4 étage
doctorant
2020
An ionizable supramolecular dendrimer nanosystem for effective siRNA delivery with a favorable safety profile
Dinesh Dhumal, Wenjun Lan, Ling Ding, Yifan Jiang, Zhenbin Lyu, Erik Laurini, Domenico Marson, Aura Tintaru, Nelson Dusetti, Suzanne Giorgio, Juan Lucio Iovanna, Sabrina Pricl, Ling Peng
Nano Research (2020)10.1007/s12274-020-3216-8 
Targeting NUPR1 with the small compound ZZW-115 is an efficient strategy to treat hepatocellular carcinoma
Wenjun Lan, Patricia Santofimia-Castaño, Yi Xia, Zhengwei Zhou, Can Huang, Nicolas Fraunhoffer, Dolores Barea, Melchiore Cervello, Lydia Giannitrapani, Giuseppe Montalto, Ling Peng, Juan Iovanna
Cancer Letters 486:8-17 (2020)10.1016/j.canlet.2020.04.024
ZZW-115-dependent inhibition of NUPR1 nuclear translocation sensitizes cancer cells to genotoxic agents
Wenjun Lan, Patricia Santofimia-Castaño, Mirna Swayden, Yi Xia, Zhengwei Zhou, Stéphane Audebert, Luc Camoin, Can Huang, Ling Peng, Ana Jiménez-Alesanco, Adrián Velázquez-Campoy, Olga Abián, Gwen Lomberk, Raul Urrutia, Bruno Rizzuti, Vincent Geli, Philippe Soubeyran, José Neira, Juan Iovanna
JCI Insight 5 (2020)10.1172/jci.insight.138117
Novel triazole nucleoside analogues promote anticancer activity via both apoptosis and autophagy
Yanhua Zhang, Xi Liu, Yun Lin, Baoping Lian, Wenjun Lan, Juan Iovanna, Xiaoxuan Liu, Ling Peng, Yi Xia
Chemical Communications 56:10014-10017 (2020)10.1039/d0cc04660d
2019
Dissecting the Anticancer Mechanism of Trifluoperazine on Pancreatic Ductal Adenocarcinoma
Can Huang, Wenjun Lan, Nicolas Fraunhoffer, Analía Meilerman, Juan Iovanna, Patricia Santofimia-Castaño
Cancers 11:1869 (2019)10.3390/cancers11121869
Ligand-based design identifies a potent NUPR1 inhibitor exerting anticancer activity via necroptosis
Patricia Santofimia-Castaño, Yi Xia, Wenjun Lan, Zhengwei Zhou, Can Huang, Ling Peng, Philippe Soubeyran, Adrián Velázquez-Campoy, Olga Abián, Bruno Rizzuti, José Neira, Juan Iovanna
Journal of Clinical Investigation 129:2500-2513 (2019)10.1172/jci127223
Flavonoid–alkylphospholipid conjugates elicit dual inhibition of cancer cell growth and lipid accumulation
Zhengwei Zhou, Biyao Luo, Xi Liu, Mimi Chen, Wenjun Lan, Juan Iovanna, Ling Peng, Yi Xia
Chemical Communications 55:8919-8922 (2019)10.1039/c9cc04084f
2018
Self-assembling supramolecular dendrimer nanosystem for PET imaging of tumors
Philippe Garrigue, Jingjie Tang, Ling Ding, Ahlem Bouhlel, Aura Tintaru, Erik Laurini, Yuanyuan Huang, Zhenbin Lyu, Mengjie Zhang, Samantha Fernandez, Laure Balasse, Wenjun Lan, Eric Mas, Domenico Marson, Yuhuang Weng, Xiaoxuan Liu, Suzanne Giorgio, Juan Iovanna, Sabrina Pricl, Benjamin Guillet, Ling Peng
Proceedings of the National Academy of Sciences of the United States of America 115:11454-11459 (2018)10.1073/pnas.1812938115
E2F signature is predictive for the pancreatic adenocarcinoma clinical outcome and sensitivity to E2F inhibitors, but not for the response to cytotoxic-based treatments
Wenjun Lan, Benjamin Bian, Yi Xia, Samir Dou, Odile Gayet, Martin Bigonnet, Patricia Santofimia-Castaño, Mei Cong, Ling Peng, Nelson Dusetti, Juan Iovanna
Scientific Reports 8:8330 (2018)10.1038/s41598-018-26613-z
Inactivation of NUPR1 promotes cell death by coupling ER-stress responses with necrosis
Patricia Santofimia-Castaño, Wenjun Lan, Jennifer Bintz, Odile Gayet, Alice Carrier, Gwen Lomberk, José Luis Neira, Antonio Gonzalez, Raul Urrutia, Philippe Soubeyran, Juan Iovanna
Scientific Reports 8 (2018)10.1038/s41598-018-35020-3