Xi Liu





Blocking stemness and metastatic properties of ovarian cancer cells by targeting p70S6K with dendrimer nanovector-based siRNA delivery

J. Ma, S. Kala, S. Yung, T.M. Chan, Y. Cao, Y. Jiang, X. Liu, S. Giorgio, L. Peng, A.S.T. Wong

Molecular Therapy 26 70-83 (2018)

A dual targeting dendrimer-mediated siRNA delivery system for effective gene silencing in cancer therapy

Y. Dong, T. Yu, L. Ding, E. Laurini, Y. Huang, M. Zhang, Y. Weng, S. Lin, P. Chen, D. Marson, Y. Jiang, S. Giorgio, S. Pricl, X. Liu, P. Rocchi, L. Peng

Journal of the American Chemical Society 140 16264-16274 (2018)

A self-assembling supramolecular dendrimer nanosystem for PET imaging of tumors

P. Garrigue, J. Tang, L. Ding, A. Bouhlel, A. Tintaru, E. Laurini, Y. Huang, Z. Lyu, M. Zhang, S. Fernandez, L. Balasse, W. Lan, E. Mas, D. Marson, Y. Weng, X. Liu, S. Giorgio, J. Iovanna, S. Pricl, B. Guillet, L. Peng

Proceedings of the National Academy of Sciences 115 11454-11459 (2018)

A chameleonic dye adapts to various environments shining on macrocycles or, peptide and polysaccharide aggregates

H. Yin, F. Dumur, Y. Niu, R. Wang, M. Ayhan, O. Grauby, W. Liu, C. Wang, D. Siri, R. Rosas, A. Tonetto, D. Gigmes, D. Bardelang, O. Ouari

ACS Applied Materials & Interfaces 9 33220–33228 (2017)

First in-flight synchrotron X-ray absorption and photoemission study of carbon soot nanoparticles

F.X. Ouf, P. Parent, C. Laffon, I MARHABA. , D. Ferry, B. Marcillaud, E. Antonsson, S. Benkoula, X.J. Liu, C. Nicolas, E. Robert, M. Patanen, F.A. Barreda, O. Sublemontier, A. Coppalle, J. Yon, F. Miserque, T. Mostefaoui, T.Z. Regier, J.B.A. Mitchell, C.

Scientific Reports 6 36495 (2016)

A fluorinated bola-amphiphilic dendrimer for on-demand delivery of siRNA via specific response to reactive oxygen species

X. Liu, Y. Wang, C. Chen, A. Tintaru, Y. Cao, J. Liu, F. Ziarelli, J. Tang, H. Guo, R. Rosas, S. Giorgio, L. Charles, P. Rocchi, L. Peng

Advanced Functional Materials 26 8594-8603 (2016)

Controlling charge separation and recombination by chemical design in donor-acceptor dyads

L. Liu, P. Eisenbrandt, T. Roland, M. Polkehn, P.O. Schwartz, K. Bruchlos, B. Omieienski, S. Ludwigs, N. Leclerc, E. Zaborova, J. Leonard, S. Mery, I. Burghardt, S. Haacke

Physical Chemistry Chemical Physics 18 27 18536-18548 (2016)

Mastering dendrimer self-assembly for efficient siRNA delivery: from conceptual design to in vivo efficient gene silencing

C. Chen, P. Posocco, X. Liu, Q. Cheng, E. Laurini, J. Zhou, C. Liu, Y. Wang, J. Tang, V.D. Col, T. Yu, S. Giorgio, M. Fermeglia, F. Qu, Z. Liang, J.J. Rossi, M. Liu, P. Rocchi, S. Pricl, L. Peng

small 12 3667-3676 (2016)

Boron Difluoride Curcuminoid Fluorophores with Enhanced Two-Photon Excited Fluorescence Emission and Versatile Living-Cell Imaging Properties

K. Kamada, T. Namikawa, S. Senatore, C. Matthews, P.F. Lenne, O. Maury, C. Andraud, M. Ponce Vargas, B. Le Guennic, D. Jacquemin, P. Agbo, D.D. An, S.S. Gauny, X. Liu, R.J. Abergel, F. Fages, A. D'aléo

Chemistry - A European Journal 22 15 5219-5232 (2016)

Dendrimer Nanovectors for SiRNA Delivery

X. Liu, L. Peng

Methods in Molecular Biology 1364 127-142 (2016)

Downregulation of TLX induces TET3 expression and inhibits glioblastoma stem cell self-renewal and tumorigenesis

Q. Cui, S. Yang, P. Ye, E. Tian, G. Sun, J. Zhou, G. Sun, X. Liu, C. Chen, K. Murai, C. Zhao, K.T. Azizian, L. Yang, C. Warden, X. Wu, M. D'apuzzo, C. Brown, B. Badie, L. Peng, A. Riggs, J. Rossi, Y. Shi

Nature Communications 7 10637 (2016)

Ligand-free synthesis of Aluminum-doped Zinc Oxide nanocrystals and their use as optical spacers in color tuned high-efficient organic solar cells

M. Gaceur, S. Ben Dkhil, D. Duché, F. Bencheikh, J.-J. Simon, L. Escoubas, M. Mansour, A. Guerrero, G. Garcia-belmonte, X. Liu, M. Fahlman, W. Dachraoui, A. K. Diallo, C. Videlot-ackermann, O. Margeat, J. Ackermann

Advanced Functional Materials 26 243 (2016)

Anticancer drug nanomicelles formed by self-assembling amphiphilic dendrimer to combat cancer drug resistance

T. Wei, C. Chen, J. Liu, C. Liu, P. Posocco, X. Liu, Q. Cheng, S. Huo, Z. Liang, M. Fermeglia, S. Pricl, X.-J. Liang, L. Peng

Proceedings of the National Academy of Sciences 112 10 2978–2983 (2015)

Promoting siRNA delivery via enhanced cellular uptake using an arginine-decorated amphiphilic dendrime

X. Liu, C. Liu, J. Zhou, C. Chen, F. Qu, J. Rossi, P. Rocchi, L. Peng

Nanoscale 7 3867-3875 (2015)

Structural characterization of new defective molecules in poly(amidoamide)dendrimers by combining mass spectrometry and nuclear magnetic resonance

A. Tintaru, R. Ungaro, X. Liu, C. Chen, L. Giordano, L. Peng, L. Charles

Analytica Chimica Acta 853 451-459 (2015)

Shape separation of gold nanoparticles using a pH-responsive amphiphilic dendrimer according to their shape anisotropy distinction

M. Hao, C. Liu, L. Peng, J. Li, W. Lu, L. Jiang

Journal of Colloid and Interface Science 437 311-315 (2015)

Gram-Scale Synthesis of Ultrathin Tungsten Oxide Nanowires and their Aspect Ratio-Dependent Photocatalytic Activity

J.C. Liu, O. Margeat, W. Dachraoui, X.J. Liu, M. Fahlman, J. Ackermann

Advanced Functional Materials 24 38 6029-6037 (2014)

Targeted delivery of Dicer substrate siRNA using a dual targeting peptide decorated dendrimer delivery system

X. Liu, C. Liu, C. Chen, M. Bentobji, F. Azario Cheillan, J. Tomassin Piana, F. Qu, P. Rocchi, L. Peng

Nanomedicine: Nanotechnology, Biology and Medicine 10 1627-1636 (2014)

Effects of ultraviolet soaking on surface electronic structures of solution processed ZnO nanoparticle films in polymer solar cells

Q.Y. Bao, X.J. Liu, Y.X. Xia, F. Gao, L.D. Kaufmann, O. Margeat, J. Ackermann, M. Fahlman

Journal of materials chemistry A2 41 17676-17682 (2014)

Adaptive amphiphilic dendrimer based nanoassemblies as robust and versatile siRNA delivery systems

X. Liu, J. Zhou, T. Yu, C. Chen, Q. Cheng, K. Sengupta, Y. Huang, H. Li, C. Liu, Y. Wang, P. Posocco, M. Wang, Q. Cui, S. Giorgio, M. Fermeglia, F. Qu, S. Pricl, Y. Shi, Z. Liang, P. Rocchi, J.J. Rossi, L. Peng

Angewandte Chemie International Edition 53 11822-11827 (2014)

Separation of rare gases and chiral molecules by selective binding in porous organic cages

L. Chen, P.S. Reiss, S.Y. Chong, D. Holden, K.E. Jelfs, T. Hasell, M.A. Little, A. Kewley, M.E. Briggs, A. Stephenson, K.M. Thomas, J.A. Armstrong, J. Bell, J. Busto, R. Noel, J. Liu, D.M. Strachan, P.K. Thallapally, A.I. Cooper

Nature Materials 13 954-960 (2014)

A ‘click’ chemistry constructed affinity system for 2-oxoglutaric acid receptors and binding proteins

Y. Wang, Z. Assaf, X. Liu, F. Ziarelli, A. Latifi, O. Lamrabet, G. Quélever, F. Qu, C-C. Zhang, L. Peng

Organic & Biomolecular Chemistry / Organic and Biomolecular Chemistry 12 6470-6475 (2014)

Structurally flexible triethanolamine-core poly(amidoamine) dendrimers as effective nanovectors to deliver RNAi-based therapeutics

X. Liu, C. Liu, C.V. Catapano, L. Peng, J. Zhou, P. Rocchi

Biotechnology Advances 32 844-852 (2014)

Mimicking 2-oxoglutaric acid signaling function using molecular probes: insights from structural and functional investigations

Y. Wang, X. Liu, E. Laurini, P. Posocco, F. Ziarelli, M. Fermeglia, F. Qu, S. Procl, C-C. Zhang, L. Peng

Organic & Biomolecular Chemistry / Organic and Biomolecular Chemistry 12 4723-4729 (2014)

Combination of dendrimer nanovector mediated small interfering RNA delivery to target Akt with clinical anticancer drug paclitaxel for effective and potent anticancer activity in treating ovarian cancer

S. Kala, A.S.C. Mak, X. Liu, P. Posoxxo, S. Pricl, L. Peng, A.S.T. Wong

Journal of Medicinal Chemistry / JOURNAL OF MEDICINAL AND PHARMACEUTICAL CHEMISTRY 57 2634-2642 (2014)

An arginine-terminated generation 4 PAMAM dendrimer as an effective nanovector for functional siRNA delivery in vitro and in vivo

C. Liu, X. Liu, P. Rocchi, F. Qu, J. Iovanna, L. Peng

Bioconjugate Chemistry 25 521-532 (2014)

A novel RNA oligonucleotide improves liver function and inhibits liver carcinogenesis in vivo

V. Reebye, P. Sætrom, P.J. Mintz, K. Wen Huang, V. Lin, P. Swiderski, L. Peng, C. Liu, L. Xiaoxuan, S. Jensen, D. Zacharoulis, N. Kostomitsopoulos, N. Kasahara, J. Nicholls, LR. Jiao, M. Pai, A. Haoudi, D.A. Tomalia, J.J. Rossi, N.A. Habib

Hepatology 59 216-227 (2014)

Copper(II) binding to structurally flexible triethanolamine-core PAMAM dendrimers: a combined experimental/in silico approach

M.F. Ottaviani, M. Cangiotti, A. Fattori, C. Coppola, P. Posocco, E. Laurini, X. Liu, C. Liu, M. Fermeglia, L. Peng, S. Pricl

Physical Chemistry Chemical Physics 16 685-694 (2014)

C-S coupling using a mixed-ligand Pd catalyst: a highly effective strategy for synthesizing arylthio-substituted heterocycles

M. Cong, Y. Fan, J-L. Raimundo, Y. Xia, Y. Liu, G. Quelever, F. Qu, L. Peng

Chemistry - A European Journal 19 17267-17272 (2013)

Conformational changes of small PAMAM dendrimers as a function of their charge state: a combined electrospray mass spectrometry, traveling-wave ion mobility and molecular modeling study

A. Tintaru, S. Pricl, L. Denbigh, X. Liu, L. Peng, L. Charles

International Journal of Mass Spectrometry 354-355 235-241 (2013)

Structural requirements of 2-oxoglutaric acid analogues to mimic its signaling function

X. Liu, Y. Wang, E. Laurini, P. Posocco, H. Chen, F. Ziarelli, A. Janicki, F. Qu, M. Fermeglia, S. Pricl, C-C. Zang, L. Peng

Organic Letters 15 4664-4665 (2013)

Impact of siRNA overhangs for dendrimer-mediated siRNA delivery and gene silencing

P. Posocco, X. Liu, E. Laurini, D. Marson, C. Chen, C. Liu, M. Fermeglia, P. Rocchi, S. Pricl, L. Peng

Molecular Pharmaceutics 10 3262-3273 (2013)

An Amphiphilic Dendrimer for Effective Delivery of Small Interfering RNA and Gene Silencing In Vitro and In Vivo

T. Yu, X. Liu, A-L. Bolcato-bellemin, Y. Wang, C. Liu, P. Erbacher, F. Qu, P. Rocchi, J-P. Behr, L. Peng

Angewandte Chemie/Angew Chem Int Ed 51 8478–8484 (2012)

Genome-wide profiling identified a set of miRNAs that are differentially expressed in glioblastoma stem cells and normal neural stem cells

M-F. Lang, S. Yang, C. Zhao, G. Sun, K. Murai, X. Wu, J. Wang, H. Gao, C.E. Brown, X. Liu, J. Zhou, L. Peng, J.J. Rossi, Y. Shi

PloS ONE 7 4 e36248 (2012)

Targeting heat shock factor I with a triazole nucleoside analog to elicit potent anticancer activity on drug-resistant pancreatic cancer

Y. Xia, Y. Liu, P. Rocchi, M. Wang, Y. Fan, F. Qu, J.L. Iovanna, L. Peng

Cancer letters 318 145-153 (2012)

Efficient Delivery of Sticky siRNA and Potent Gene Silencing in a Prostate Cancer Model Using a Generation 5 Triethanolamine-Core PAMAM Dendrimer

X. Liu, C. Liu, E. Laurini, P. Posocco, S. Pricl, F. Qu, P. Rocchi, L. Peng

Molecular Pharmaceutics 9 3 470-481 (2012)

Dendrimers as non-viral vectors for siRNA delivery

X. Liu, P. Rocchi, L. Peng

New Journal of Chemistry 36 256-263 (2012)

Rationally designed structurally flexible PAMAM dendrimers as efficient vectors for DNA transfection in vitro and in vivo to mouse thymus

X. Liu, J. Wu, M. Yamine, J. Zhou, P. Posocco, S. Viel, C. Liu, F. Ziarrelli, M. Fermeglia, S. Pricl, G. Vicotrero, C. Nguyen, P. Erbacher, J.-P. Behr, L. Peng

Bioconjugate Chemistry 22 2461-2473 (2011)

Systemic administration of dendrimer-siRNA complexes efficiently suppresses HIV-1 infection

J. Zhou, P. Neff, X. Liu, J. Zhang, H. Li, D.D. Smith, P. Swiderski, Y. Huang, Q. Du, Z. Liang, L. Peng, R. Akkina, J. Rossi

Molecular Therapy 19 2228-2238 (2011)

Photoactivatable phospholipids bearing tetrafluorophenylazido chromophores exhibit unprecedented protonation state - dependent 19F-NMR signals

Y. Xia, F. Qu, A. Maggiani, K. Sengupta, C. Liu, L. Peng

Organic Letters 13 4248-4251 (2011)

2-Difluoromethylene-4-methylenepentanoic Acid, A Paradoxical Probe Able To Mimic the Signaling Role of 2-Oxoglutaric Acid in Cyanobacteria

X.J. Liu, H. Chen, E. Laurini, Y. Wang, V. Dal Col, P. Posocco, F. Ziarelli, M. Fermeglia, C.C. Zhang, S. Pricl, L. Peng

Organic Letters 13 11 2924-2927 (2011)

Surface morphology and structure of ultra-thin magnesium oxide grown on (100) silicon by atomic layer deposition oxidation

N. Rochdi, K. Liudvikouskaya, M. Descoins, M. Raïssi, C. Coudreau, J.-L. Lazzari, H. Oughaddou, F. Arnaud D’avitaya

Thin Solid Films 519 19 6302-6306 (2011)

S-Aryltriazole acyclonucleosides: Synthesis and biological evaluation against hepatitis C virus

Y. Liu, Y. Xia, W. Li, M. Cong, A. Maggiani, P. Leyssen, F. Qu, J. Neyts, L. Peng

Bioorganic & Medicinal Chemistry Letters / Bioorganic and Medicinal Chemistry Letters 20 12 3610-3613 (2010)

N-Aryltriazole ribonucleosides with potent antiproliferative activity against drug-resistant pancreatic cancer

Y. Liu, Y. Xia, Y. Fan, A. Maggiani, P. Rocchi, F. Qu, J.L. Iovanna, L. Peng

Bioorganic & Medicinal Chemistry Letters / Bioorganic and Medicinal Chemistry Letters 20 2503-2507 (2010)

Adsorption and Reaction of Rh(CO)2(acac) on Al2O3/Ni3Al(111)

Y. Lei, A. Uhl, J. Liu, C. Becker, K. Wandelt, B.C. Gates, R. Meyer, M. Trenary

Physical Chemistry Chemical Physics 12 1264–1270 (2010)

A Novel Triazole Ribonucleoside Down-regulates Heat Shock Protein 27 and Induces Potent Anticancer Activity on Drug-resistant Pancreatic Cancer

Y. Xia, Y. Liu, J. Wan, M. Wang, P. Rocchi, F. Qu, J.L. Iovanna, L. Peng

Journal of Medicinal Chemistry / JOURNAL OF MEDICINAL AND PHARMACEUTICAL CHEMISTRY 52 6083-6096 (2009)

PAMAM dendrimer mediated siRNA delivery to target heat-shock protein 27 and produce potent antiproliferation effect on prostate cancer PC-3 cells

X. Liu, P. Rocci, F. Qu, S. Zheng, Z. Liang, M. Cleave, J. Iovanna, L. Peng

ChemMedChem 4 1302-1310 (2009)

Discovery of novel arylethynyltriazole Ribonucleosides with selective and effective antiviral and anti-proliferative activity

J. Wan, Y. Xia, Y. Liu, M. Wang, P. Rocchi, J. Yao, F. Qu, J. Neyts, J.L. Iovanna, L. Peng

Journal of Medicinal Chemistry / JOURNAL OF MEDICINAL AND PHARMACEUTICAL CHEMISTRY 52 1144-1155 (2009)

Importance of Size to Charge Ratio in Construction of Stable and Uniform Nanoscale RNA/dendrimer Complexes

X-C. Shen, J. Zhou, X. Liu, J. Wu, F. Qu, Z-L. Zhang, D.W. Pang, G. Quélever, C.X. Zhang, L. Peng

Organic & Biomolecular Chemistry / Organic and Biomolecular Chemistry 5 3674-3681 (2007)

Synthesis of Bitriazolyl Nucleosides and Unexpectedly Different Reactivity of Azidotriazole Nucleoside Isomers in Huisgen Reaction

Y. Xia, W. Li, F. Qu, Z. Fan, X. Liu, C. Berro, E. Rauzy, L. Peng

Organic & Biomolecular Chemistry / Organic and Biomolecular Chemistry 5 1695-1701 (2007)

Cooperative Binding and Self-Assembling Behavior of Cationic Low-Molecular-Weight Dendrons with RNA Molecules

J. Zhou, J. Wu, X. Liu, F. Qu, M. Xiao, Y. Zhang, L. Charles, C.-C. Zhang, L. Peng

Organic & Biomolecular Chemistry / Organic and Biomolecular Chemistry 4 581-585 (2006)