CINaM - Centre Interdisciplinaire de Nanoscience de Marseille


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  • 13288 Marseille Cedex 9
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A venir ...

Jeudi 11 Février 2016
Valessa BARBIER,
Université Paris-Est de Créteil
A new polymeric scaffold for biomimetic applications: synthetic membranes, membrane permeabilization and multivalent ligands for molecular recognition.
In the framework of research projects aimed at designing polymers with biomimetic features, we have developed a new polymeric scaffold, dubbed OCD for Oligomers from Cyclopropane Dicarboxylates monomers. They have geminal substituants located on every third carbon along a polymethylene backbone and are obtained by Anionic Ring Opening Polymerization using a phosphazene base to generate in situ the polymerisation initiator.1 Biomimetic nano-objets have been designed such as synthetic membranes made by the self-assembly of amphiphilic liquid crystal (LC) PEG-OCD block copolymers.2 Crown-ethers substituted OCDs have also been developed as potential biological membrane permeabilizers.3 They form cation-selective pores within model bilipidic membranes,4 and their interaction with biological membranes has been studied. More recently, a new family of glycopolymers have been synthesized by post-modification of an OCD scaffold using the thiol-ene radical addition and their interaction with carbohydrate-binding proteins have been investigated.5,6 [1] N. Illy, S. Boileau, W. Buchmann, J. Penelle, V. Barbier, Macromolecules 2010, 43, 8782–8789. [2] L. Jia, M. Liu, A. Di-Cicco, P-A. Albouy, B. Brissault, J. Penelle, S. Boileau, V. Barbier, M-H. Li, Langmuir 2012, 28, 11215–11224. [3] M. Liu, S. Peyrat, N. Illy, V. Wintgens, B. Brissault, J. Penelle, V. Barbier, J. Polym. Sci., Part A: Polym. Chem. 2014, 52, 2337–2345. [4] M. Liu, A. Bertova, N. Illy, B. Brissault, J. Penelle, K. Ondrias, V. Barbier, RSC Adv., 2012, 2, 8606 – 8609. [5] N. Illy, S. Boileau, M.A. Winnik, J. Penelle, V. Barbier, Polymer 2012, 53, 903–912. [6] M. Fiore, N. Berthet, O. Renaudet, V. Barbier, Med. Chem. Commun. 2014, 5, 1202 – 1207.

Jeudi 10 Mars 2016
Peter Zeppenfeld
Université de Linz, Autriche

Jeudi 31 Mars 2016
Thomas LEONI
dpt NMR, CINaM

Jeudi 9 Juin 2016
Laboratoire de Géologie de Lyon : Terre, Planète, Environnement Ecole Normale Supérieure de Lyon
L'eau dans le système solaire