CINaM - Centre Interdisciplinaire de Nanoscience de Marseille

Partenaires

CINaM
CNRS
Logo tutelle
UMI



Rechercher

Sur le Web du CNRS


  • CINaM
  • Campus de Luminy
  • Case 913
  • 13288 Marseille Cedex 9
  •  
  • Tel : +33(0)4 91 17 28 00
  • Fax : +33(0)4 91 41 89 16

Accueil du site > À la une > Negative Dendritic Effect on Enzymatic Hydrolysis of Dendrimer Conjugates

Negative Dendritic Effect on Enzymatic Hydrolysis of Dendrimer Conjugates

Zhengwei Zhou, Mei Cong, Mengyao Li, Aura Tintaru, Jia Li, Jianhua Yao, Yi Xia and Ling Peng

Chemical Communications 2018, 54, 5956-5959

Dendrimers possess intriguing “dendritic effects”, which are unique characteristics that stem from the dendrimer generation and size. In this paper, we report a “negative dendritic effect” observed during enzymatic hydrolysis of dendrimer conjugates. Such negative dendritic effects, though rarely reported, may be explored for tailored and generation-dependent drug release. Specifically, we prepared covalent dendrimer conjugates using click chemistry and studied the release of a bioactive entity from the conjugates during enzymatic hydrolysis of the ester linkage. Our results showed that the enzymatic hydrolysis of the dendrimer conjugates was greatly impacted by dendritic structure and dendrimer generation. Higher-generation dendrimers had considerably slower enzymatic hydrolysis. Such negative dendritic effects, though rarely reported, can be positively exploited to design and construct generation-dependent dendrimer conjugates with tailored stability for achieving controllable drug release. It may constitute a promising alternative strategy to enable controlled delivery of therapeutic agents.

This work is issued from collaboration between Prof Yi Xia at Chongqing University, Dr. Jiahua Yao at Shanghai Institute of Organic Chemistry in China, Dr. Aura Tintaru and Dr. Ling Peng at the CNRS/Aix-Marseille University in France.

Contact : Ling Peng

Ref : Zhou et al, Chemical Communications 2018, 54, 5956-5959 Doi : 10.1039/C8CC01221K

JPG - 99 ko