{"id":9326,"date":"2021-07-15T11:11:08","date_gmt":"2021-07-15T09:11:08","guid":{"rendered":"http:\/\/www.cinam.univ-mrs.fr\/cinam\/cristallisation-en-microfluidique\/"},"modified":"2022-02-24T16:12:53","modified_gmt":"2022-02-24T15:12:53","slug":"cristallisation-en-microfluidique","status":"publish","type":"page","link":"https:\/\/www.cinam.univ-mrs.fr\/cinam\/en\/cristallisation-en-microfluidique\/","title":{"rendered":"Microfluidic Crystallization"},"content":{"rendered":"<div id=\"pl-9326\"  class=\"panel-layout\" ><div id=\"pg-9326-0\"  class=\"panel-grid panel-no-style\" ><div id=\"pgc-9326-0-0\"  class=\"panel-grid-cell\" ><div id=\"panel-9326-0-0-0\" class=\"so-panel widget widget_sow-editor panel-first-child panel-last-child\" data-index=\"0\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-editor so-widget-sow-editor-base\"\n\t\t\t\n\t\t>\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p>In the context of Microfluidic crystallisation, we are developing :<\/p>\n<p>a versatile microfluidic tool that is easy to use by non-specialists for the optimisation and screening of crystallization conditions, the rapid establishment of phase diagrams and the measurement of crystal nucleation kinetics (volume nL),<\/p>\n<p>the controlled generation of microdroplets (volume from pL to fL) for the study of crystal nucleation in confined environments,<\/p>\n<p>the use of extremely sharp nano-electrodes (radius of curvature of a few nanometres) to trigger and localise nucleation in time and space, either mechanically or by the creation of an intense electric field, localised in the vicinity of the tip and allowing the control of flows in the solution<\/p>\n<p>&nbsp;<\/p>\n<ul>\n<li><a href=\"http:\/\/www.cinam.univ-mrs.fr\/cinam\/en\/?page_id=9422\">Cristallisation and Drug Design<\/a><\/li>\n<li><a href=\"http:\/\/www.cinam.univ-mrs.fr\/cinam\/en\/?page_id=9487\">Crystallization of Model Systems<\/a><\/li>\n<li><a href=\"http:\/\/www.cinam.univ-mrs.fr\/cinam\/en\/?page_id=9471\">Characterization of Membrane Proteins<\/a><\/li>\n<li><a href=\"http:\/\/www.cinam.univ-mrs.fr\/cinam\/en\/nucleation-and-crystallization-controlled-in-confined-environments\/\">Nucleation in confined environments<\/a><\/li>\n<li><a href=\"http:\/\/www.cinam.univ-mrs.fr\/cinam\/en\/nanoelectrolysis-of-water\/\">From nanoelectrolysis of water to controlled nucleation of bubbles and crystals<\/a><\/li>\n<\/ul>\n<\/div>\n<\/div><\/div><\/div><div id=\"pgc-9326-0-1\"  class=\"panel-grid-cell\" ><div id=\"panel-9326-0-1-0\" class=\"so-panel widget widget_sow-editor panel-first-child panel-last-child\" data-index=\"1\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-editor so-widget-sow-editor-base\"\n\t\t\t\n\t\t>\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<figure id=\"attachment_5518\" aria-describedby=\"caption-attachment-5518\" style=\"width: 600px\" class=\"wp-caption alignnone\"><img decoding=\"async\" loading=\"lazy\" class=\"wp-image-5518 size-full\" src=\"http:\/\/www.cinam.univ-mrs.fr\/cinam\/wp-content\/uploads\/2019\/04\/plateforme-microfluidic-e1555508644189.jpg\" alt=\"\" width=\"600\" height=\"277\" \/><figcaption id=\"caption-attachment-5518\" class=\"wp-caption-text\">Microfluidic platform for crystallization<\/figcaption><\/figure>\n<figure id=\"attachment_3365\" aria-describedby=\"caption-attachment-3365\" style=\"width: 999px\" class=\"wp-caption alignnone\"><img decoding=\"async\" loading=\"lazy\" class=\"wp-image-3365 size-full\" src=\"http:\/\/www.cinam.univ-mrs.fr\/cinam\/wp-content\/uploads\/2018\/11\/local-probes-and-sources.jpg\" alt=\"Sources et Sondes Ponctuelles 30\" width=\"999\" height=\"608\" srcset=\"https:\/\/www.cinam.univ-mrs.fr\/cinam\/wp-content\/uploads\/2018\/11\/local-probes-and-sources.jpg 999w, https:\/\/www.cinam.univ-mrs.fr\/cinam\/wp-content\/uploads\/2018\/11\/local-probes-and-sources-300x183.jpg 300w, https:\/\/www.cinam.univ-mrs.fr\/cinam\/wp-content\/uploads\/2018\/11\/local-probes-and-sources-768x467.jpg 768w\" sizes=\"(max-width: 706px) 89vw, (max-width: 767px) 82vw, 740px\" \/><figcaption id=\"caption-attachment-3365\" class=\"wp-caption-text\">Generation of a network of microdroplets of aqueous phase in oil<\/figcaption><\/figure>\n<figure id=\"attachment_9016\" aria-describedby=\"caption-attachment-9016\" style=\"width: 246px\" class=\"wp-caption alignnone\"><img decoding=\"async\" loading=\"lazy\" class=\"wp-image-9016 size-full\" src=\"http:\/\/www.cinam.univ-mrs.fr\/cinam\/wp-content\/uploads\/2021\/07\/pointe_lyso.jpg\" alt=\"\" width=\"246\" height=\"302\" srcset=\"https:\/\/www.cinam.univ-mrs.fr\/cinam\/wp-content\/uploads\/2021\/07\/pointe_lyso.jpg 246w, https:\/\/www.cinam.univ-mrs.fr\/cinam\/wp-content\/uploads\/2021\/07\/pointe_lyso-244x300.jpg 244w\" sizes=\"(max-width: 246px) 100vw, 246px\" \/><figcaption id=\"caption-attachment-9016\" class=\"wp-caption-text\">Localized crystallization of a protein at the apex of a tip by a localized electric field<\/figcaption><\/figure>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>In the context of Microfluidic crystallisation, we are developing : a versatile microfluidic tool that is easy to use by non-specialists for the optimisation and screening of crystallization conditions, the rapid establishment of phase diagrams and the measurement of crystal nucleation kinetics (volume nL), the controlled generation of microdroplets (volume from pL to fL) for <\/p>\n","protected":false},"author":5,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.cinam.univ-mrs.fr\/cinam\/en\/wp-json\/wp\/v2\/pages\/9326"}],"collection":[{"href":"https:\/\/www.cinam.univ-mrs.fr\/cinam\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.cinam.univ-mrs.fr\/cinam\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.cinam.univ-mrs.fr\/cinam\/en\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/www.cinam.univ-mrs.fr\/cinam\/en\/wp-json\/wp\/v2\/comments?post=9326"}],"version-history":[{"count":13,"href":"https:\/\/www.cinam.univ-mrs.fr\/cinam\/en\/wp-json\/wp\/v2\/pages\/9326\/revisions"}],"predecessor-version":[{"id":9849,"href":"https:\/\/www.cinam.univ-mrs.fr\/cinam\/en\/wp-json\/wp\/v2\/pages\/9326\/revisions\/9849"}],"wp:attachment":[{"href":"https:\/\/www.cinam.univ-mrs.fr\/cinam\/en\/wp-json\/wp\/v2\/media?parent=9326"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}