{"id":11871,"date":"2023-03-14T11:53:31","date_gmt":"2023-03-14T10:53:31","guid":{"rendered":"http:\/\/www.cinam.univ-mrs.fr\/cinam\/?p=11871"},"modified":"2023-03-14T13:31:42","modified_gmt":"2023-03-14T12:31:42","slug":"thesis-defence-2","status":"publish","type":"post","link":"https:\/\/www.cinam.univ-mrs.fr\/cinam\/en\/2023\/03\/14\/thesis-defence-2\/","title":{"rendered":"Thesis defence"},"content":{"rendered":"

Title<\/strong> : Microfluidic approach to crystallize the different phases of an active pharmaceutical ingredient<\/p>\n

The jury will be composed by :<\/span><\/p>\n

Val\u00e9rie DUPRAY<\/span><\/b>, Rapporteuse<\/span><\/p>\n

SMS – Universit\u00e9 de Rouen Normandie (Rouen)<\/span><\/p>\n

Fran\u00e7ois PUEL<\/span><\/b>, Rapporteur<\/span><\/p>\n

CentraleSup\u00e9lec – Universit\u00e9 Paris Saclay (Gif-sur-Yvette)<\/p>\n

Alexandra PE\u00d1A REVELLEZ<\/span><\/b>, Examinatrice<\/span><\/p>\n

Institut N\u00e9el – CNRS (Grenoble)<\/span><\/p>\n

Pierrette GUICHARDON<\/b>, Pr\u00e9sidente\u00a0 du jury<\/span><\/p>\n

Centrale Marseille (Marseille)<\/span><\/p>\n

St\u00e9phane VEESLER<\/span><\/b>,\u00a0<\/b>Directeur de th\u00e8se<\/b><\/span><\/p>\n

Aix-Marseille Univ, CNRS, CINAM (Marseille)<\/span><\/p>\n

Nadine CANDONI<\/span><\/b>, Codirectrice de th\u00e8se<\/b><\/span><\/p>\n

Aix-Marseille Univ, CNRS, CINAM (Marseille)<\/span><\/p>\n

Beno\u00eet ROBERT<\/b>, Invit\u00e9<\/span><\/p>\n

Sanofi-Aventis R&D (Vitry-sur-Seine)<\/span><\/p>\n

Romain GROSSIER<\/b>, Invit\u00e9<\/span><\/p>\n

Aix-Marseille Univ, CNRS, CINAM (Marseille)<\/span><\/p>\n

Abstract :<\/b><\/p>\n

Most of the active pharmaceutical ingredients (API) can exist, in the solid state, under several crystalline phases (polymorphs,\u00a0solvates, cocristals…). These phases have different physicochemical properties, which can affect the drug\u00a0efficacy and its manufacturing process. In the pharmaceutical industry, a solid-state screening is thus carried out in the\u00a0early stages of a drug development, to identify the existing phases and choose the one to develop. At this step, only a\u00a0small amount of raw material is available, reducing the number of experiments. Droplet microfluidics is used to reduce the\u00a0crystallization volumes to nanoliter scale, and thus the amount of product. This makes it possible to increase the number of\u00a0experiments, bringing a statistical approach to address the stochasticity of nucleation. This thesis presents the development\u00a0of a modular microfluidic platform, easy to use and compatible with most solvents, for solid-state screening of\u00a0active pharmaceutical ingredients and fundamental nucleation studies. It enables to generate saturated solutions and\u00a0droplets starting from powder and their characterization, to measure solubility, to crystallize API by cooling or non-solvent\u00a0addition processes and to monitor nucleation in time and as a function of the temperature to establish global statistics\u00a0on nucleation (all phases included). Lastly, the different phases are identified in situ by Raman spectroscopy to\u00a0perform phase to phase statistics.<\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

Mathilde Lambert will speak on Wednesday, March 29th at 10:30 in the Kern room (CINaM)<\/p>\n","protected":false},"author":16,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[5],"tags":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.cinam.univ-mrs.fr\/cinam\/en\/wp-json\/wp\/v2\/posts\/11871"}],"collection":[{"href":"https:\/\/www.cinam.univ-mrs.fr\/cinam\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.cinam.univ-mrs.fr\/cinam\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.cinam.univ-mrs.fr\/cinam\/en\/wp-json\/wp\/v2\/users\/16"}],"replies":[{"embeddable":true,"href":"https:\/\/www.cinam.univ-mrs.fr\/cinam\/en\/wp-json\/wp\/v2\/comments?post=11871"}],"version-history":[{"count":2,"href":"https:\/\/www.cinam.univ-mrs.fr\/cinam\/en\/wp-json\/wp\/v2\/posts\/11871\/revisions"}],"predecessor-version":[{"id":11873,"href":"https:\/\/www.cinam.univ-mrs.fr\/cinam\/en\/wp-json\/wp\/v2\/posts\/11871\/revisions\/11873"}],"wp:attachment":[{"href":"https:\/\/www.cinam.univ-mrs.fr\/cinam\/en\/wp-json\/wp\/v2\/media?parent=11871"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.cinam.univ-mrs.fr\/cinam\/en\/wp-json\/wp\/v2\/categories?post=11871"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.cinam.univ-mrs.fr\/cinam\/en\/wp-json\/wp\/v2\/tags?post=11871"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}