{"id":14806,"date":"2026-09-22T13:46:21","date_gmt":"2026-09-22T11:46:21","guid":{"rendered":"https:\/\/www.cinam.univ-mrs.fr\/cinam\/?p=14806"},"modified":"2026-09-22T13:47:56","modified_gmt":"2026-09-22T11:47:56","slug":"concerted-action-of-targeted-nucleic-acid-therapeutics-as-flexible-precision-and-personalized-cancer-treatment","status":"publish","type":"post","link":"https:\/\/www.cinam.univ-mrs.fr\/cinam\/en\/2026\/09\/22\/concerted-action-of-targeted-nucleic-acid-therapeutics-as-flexible-precision-and-personalized-cancer-treatment\/","title":{"rendered":"Concerted Action of Targeted Nucleic Acid Therapeutics as Flexible, Precision and Personalized Cancer Treatment"},"content":{"rendered":"

Advanced Science<\/em><\/p>\n

DOI: 10.1002\/advs.76840<\/p>\n

Scientific Contact :<\/strong><\/em><\/p>\n

Ling Peng<\/strong>\u00a0 |\u00a0 Aix Marseille University, CNRS, Centre Interdisciplinaire de Nanoscience de Marseille (CINaM), UMR 7325, Equipe Labellisee Ligue Contre le Cancer, Marseille, France.<\/p>\n

This study presents a promising new approach to treating pancreatic cancer, a complex disease in which genetic changes can vary greatly from one patient to another. Instead of targeting a single gene, the researchers combine two types of RNA-based therapies\u00a0: small inferring RNA (siRNA) to switch off gene that promote tumor growth, and small activating RNA (saRNA) to reactivate gene that normally help stop tumor growth. To deliver these RNAs into cancer cells, the researchers use a nanovector dendrimer, a specially designed structure that can help transport the RNA molecules across cellular barriers.<\/p>\n

The key innovation is the personalized and precise nature of the treatment. By analyzing the molecular characteristics of tumors from 45 patients, the researchers designed tailor-made combinations of siRNAs and saRNAs for different tumors. These combinations were then tested in patient-derived tumor models, including primary cancer cells, 3D organoids, and mice carrying patient-derived tumors (Figure). The results showed enhanced anticancer activity, in particular because the different RNAs could work together and produce synergistic effects.<\/p>\n

Published in Advanced Science<\/em>, this work represents an important step toward a more personalized and programmable form of precision medicine. In the future, RNA combinations could potentially be designed to match the molecular characteristics of each patient’s tumor, and perhaps be adapted to other complex diseases as well.<\/p>\n

\"\"<\/p>\n

Figure\u00a0: saRNA\/siRNA combinations as a precision treatment strategy for pancreatic cancer. <\/strong>Gene and protein measurements from patient-derived pancreatic tumor samples are used to design RNA combinations matched to tumor molecular profiles. The combinations are then formulated with an amphiphilic dendrimer-based delivery vector and evaluated in patient-derived cancer cells, 3D organoids and tumor models grown in mice.<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"

A new publication in IMMF Department<\/p>\n","protected":false},"author":16,"featured_media":14813,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[31,5],"tags":[],"class_list":["post-14806","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-highlights-en","category-news"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.cinam.univ-mrs.fr\/cinam\/en\/wp-json\/wp\/v2\/posts\/14806","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.cinam.univ-mrs.fr\/cinam\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.cinam.univ-mrs.fr\/cinam\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.cinam.univ-mrs.fr\/cinam\/en\/wp-json\/wp\/v2\/users\/16"}],"replies":[{"embeddable":true,"href":"https:\/\/www.cinam.univ-mrs.fr\/cinam\/en\/wp-json\/wp\/v2\/comments?post=14806"}],"version-history":[{"count":6,"href":"https:\/\/www.cinam.univ-mrs.fr\/cinam\/en\/wp-json\/wp\/v2\/posts\/14806\/revisions"}],"predecessor-version":[{"id":14832,"href":"https:\/\/www.cinam.univ-mrs.fr\/cinam\/en\/wp-json\/wp\/v2\/posts\/14806\/revisions\/14832"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.cinam.univ-mrs.fr\/cinam\/en\/wp-json\/wp\/v2\/media\/14813"}],"wp:attachment":[{"href":"https:\/\/www.cinam.univ-mrs.fr\/cinam\/en\/wp-json\/wp\/v2\/media?parent=14806"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.cinam.univ-mrs.fr\/cinam\/en\/wp-json\/wp\/v2\/categories?post=14806"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.cinam.univ-mrs.fr\/cinam\/en\/wp-json\/wp\/v2\/tags?post=14806"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}