{"id":4161,"date":"2019-04-10T11:00:25","date_gmt":"2019-04-10T09:00:25","guid":{"rendered":"http:\/\/www.cinam.univ-mrs.fr\/cinam\/2019\/04\/01\/solubility-and-%c2%b5f\/"},"modified":"2019-04-19T12:38:35","modified_gmt":"2019-04-19T10:38:35","slug":"solubility-and-%c2%b5f","status":"publish","type":"post","link":"https:\/\/www.cinam.univ-mrs.fr\/cinam\/en\/2019\/04\/10\/solubility-and-%c2%b5f\/","title":{"rendered":"Solubility and Microfluidic"},"content":{"rendered":"<p style=\"text-align: left;\"><a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.oprd.8b00300\"><code><\/code><code><\/code>This communication<\/a> presents a new microfluidics device for solubility measurement based on the generation of saturated solutions starting from powder and compatible with all solvents and molecules. This device is simple and easily incorporated into any laboratory, even those not specialized in microfluidics. We described the method used to measure solubility, applied here to the pharmaceutical <img decoding=\"async\" loading=\"lazy\" class=\"alignleft wp-image-5443 size-medium\" title=\"SOLUBILITY MEASUREMENT USING MICROFLUIDIC\" src=\"http:\/\/www.cinam.univ-mrs.fr\/cinam\/wp-content\/uploads\/2019\/04\/solubility_microfluidic-300x79.jpg\" alt=\"\" width=\"300\" height=\"79\" srcset=\"https:\/\/www.cinam.univ-mrs.fr\/cinam\/wp-content\/uploads\/2019\/04\/solubility_microfluidic-300x79.jpg 300w, https:\/\/www.cinam.univ-mrs.fr\/cinam\/wp-content\/uploads\/2019\/04\/solubility_microfluidic-768x203.jpg 768w, https:\/\/www.cinam.univ-mrs.fr\/cinam\/wp-content\/uploads\/2019\/04\/solubility_microfluidic-1024x271.jpg 1024w, https:\/\/www.cinam.univ-mrs.fr\/cinam\/wp-content\/uploads\/2019\/04\/solubility_microfluidic.jpg 1299w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/>molecules paracetamol and gliclazide in different solvents. The device rapidly measures the solubility of a compound at a variety of temperatures ranging from 20 to 60\u00b0C using extremely small quantities (here, only 30mg) of material, with a concentration range from mg\/mL to hundreds of mg\/mL.<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>This communication presents a new microfluidics device for solubility measurement based on the generation of saturated solutions starting from powder and compatible with all solvents and molecules<\/p>\n<p>Guillem Peybern\u00e8s, Romain Grossier, Fr\u00e9d\u00e9ric Villard, Philippe Letellier, Mehdi Lagaize, Nadine Candoni, St\u00e9phane Veesler<br \/>\nOrganic Process Research and Development 22:1856-1860 (2018)10.1021<\/p>\n","protected":false},"author":5,"featured_media":3773,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[31],"tags":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.cinam.univ-mrs.fr\/cinam\/en\/wp-json\/wp\/v2\/posts\/4161"}],"collection":[{"href":"https:\/\/www.cinam.univ-mrs.fr\/cinam\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.cinam.univ-mrs.fr\/cinam\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.cinam.univ-mrs.fr\/cinam\/en\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/www.cinam.univ-mrs.fr\/cinam\/en\/wp-json\/wp\/v2\/comments?post=4161"}],"version-history":[{"count":8,"href":"https:\/\/www.cinam.univ-mrs.fr\/cinam\/en\/wp-json\/wp\/v2\/posts\/4161\/revisions"}],"predecessor-version":[{"id":5614,"href":"https:\/\/www.cinam.univ-mrs.fr\/cinam\/en\/wp-json\/wp\/v2\/posts\/4161\/revisions\/5614"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.cinam.univ-mrs.fr\/cinam\/en\/wp-json\/wp\/v2\/media\/3773"}],"wp:attachment":[{"href":"https:\/\/www.cinam.univ-mrs.fr\/cinam\/en\/wp-json\/wp\/v2\/media?parent=4161"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.cinam.univ-mrs.fr\/cinam\/en\/wp-json\/wp\/v2\/categories?post=4161"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.cinam.univ-mrs.fr\/cinam\/en\/wp-json\/wp\/v2\/tags?post=4161"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}