{"id":14795,"date":"2026-09-22T13:46:21","date_gmt":"2026-09-22T11:46:21","guid":{"rendered":"https:\/\/www.cinam.univ-mrs.fr\/cinam\/?p=14795"},"modified":"2026-09-22T13:48:22","modified_gmt":"2026-09-22T11:48:22","slug":"action-concertee-des-therapies-ciblees-a-base-dacides-nucleiques-un-traitement-du-cancer-flexible-precis-et-personnalise","status":"publish","type":"post","link":"https:\/\/www.cinam.univ-mrs.fr\/cinam\/2026\/09\/22\/action-concertee-des-therapies-ciblees-a-base-dacides-nucleiques-un-traitement-du-cancer-flexible-precis-et-personnalise\/","title":{"rendered":"Action concert\u00e9e des th\u00e9rapies cibl\u00e9es \u00e0 base d’acides nucl\u00e9iques : un traitement du cancer flexible, pr\u00e9cis et personnalis\u00e9"},"content":{"rendered":"

Advanced Science<\/em><\/p>\n

DOI: 10.1002\/advs.76840<\/p>\n

Scientific Contact<\/strong>\u00a0:\u00a0 Ling Peng<\/strong>\u00a0 |\u00a0 Aix Marseille University, CNRS, Centre Interdisciplinaire de Nanoscience de Marseille (CINaM), UMR 7325, Equipe Labellisee Ligue Contre le Cancer, Marseille, France.<\/p>\n

Cette \u00e9tude propose une avanc\u00e9e dans le traitement du cancer du pancr\u00e9as, une maladie complexe o\u00f9 les anomalies g\u00e9n\u00e9tiques varient d\u2019un patient \u00e0 l\u2019autre. Plut\u00f4t que de cibler un seul g\u00e8ne, les chercheurs combinent des traitements \u00e0 base d\u2019ARN : les siARN<\/em> bloquent les g\u00e8nes favorisant la croissance tumorale, tandis que les saARN<\/em> r\u00e9activent ceux qui la freinent. Pour acheminer ces ARN jusqu\u2019aux cellules, ils utilisent un dendrimere nanom\u00e9trique, une structure capable de franchir les barri\u00e8res cellulaires.<\/p>\n

L\u2019originalit\u00e9 r\u00e9side dans la personnalisation et la programmation : apr\u00e8s avoir analys\u00e9 les caract\u00e9ristiques mol\u00e9culaires de tumeurs de 45 patients, les chercheurs con\u00e7oivent des combinaisons de siARN\/saARN sur mesure. Test\u00e9es sur des mod\u00e8les de tumeurs issue de patients (sous formes\u00a0des cellules, des organo\u00efdes 3D et des souris x\u00e9nogreff\u00e9es), ces combinaisons montrent une efficacit\u00e9 anticanc\u00e9reuse accrue, notamment gr\u00e2ce \u00e0 des effets synergiques.<\/p>\n

Cette approche, publi\u00e9e dans Advanced Science<\/em>, marque un tournant vers une m\u00e9decine de pr\u00e9cision personnalis\u00e9e et programmable, o\u00f9 les ARN pourraient \u00eatre adapt\u00e9s \u00e0 chaque tumeur de patient, voire \u00e0 d\u2019autres maladies complexes. Bien que prometteuse, elle n\u00e9cessite encore des validations cliniques pour confirmer sa s\u00e9curit\u00e9 et son efficacit\u00e9 \u00e0 grande \u00e9chelle.<\/p>\n

\"\"<\/p>\n

Figure\u00a0: saRNA\/siRNA combinations as a precision treatment strategy for pancreatic cancer. <\/strong>Gene and protein measurements from patient-derived pancreatic tumor samples are used to design RNA combinations matched to tumor molecular profiles. The combinations are then formulated with an amphiphilic dendrimer-based delivery vector and evaluated in patient-derived cancer cells, 3D organoids and tumor models grown in mice.<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"

Une nouvelle publication dans le D\u00e9partement IMMF<\/p>\n","protected":false},"author":16,"featured_media":14812,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[],"class_list":["post-14795","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-highlights"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.cinam.univ-mrs.fr\/cinam\/wp-json\/wp\/v2\/posts\/14795","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.cinam.univ-mrs.fr\/cinam\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.cinam.univ-mrs.fr\/cinam\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.cinam.univ-mrs.fr\/cinam\/wp-json\/wp\/v2\/users\/16"}],"replies":[{"embeddable":true,"href":"https:\/\/www.cinam.univ-mrs.fr\/cinam\/wp-json\/wp\/v2\/comments?post=14795"}],"version-history":[{"count":10,"href":"https:\/\/www.cinam.univ-mrs.fr\/cinam\/wp-json\/wp\/v2\/posts\/14795\/revisions"}],"predecessor-version":[{"id":14833,"href":"https:\/\/www.cinam.univ-mrs.fr\/cinam\/wp-json\/wp\/v2\/posts\/14795\/revisions\/14833"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.cinam.univ-mrs.fr\/cinam\/wp-json\/wp\/v2\/media\/14812"}],"wp:attachment":[{"href":"https:\/\/www.cinam.univ-mrs.fr\/cinam\/wp-json\/wp\/v2\/media?parent=14795"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.cinam.univ-mrs.fr\/cinam\/wp-json\/wp\/v2\/categories?post=14795"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.cinam.univ-mrs.fr\/cinam\/wp-json\/wp\/v2\/tags?post=14795"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}