{"id":4046,"date":"2019-04-10T11:00:25","date_gmt":"2019-04-10T09:00:25","guid":{"rendered":"http:\/\/www.cinam.univ-mrs.fr\/cinam\/?p=4046"},"modified":"2019-04-19T12:37:41","modified_gmt":"2019-04-19T10:37:41","slug":"solubility-and-%c2%b5f","status":"publish","type":"post","link":"https:\/\/www.cinam.univ-mrs.fr\/cinam\/2019\/04\/10\/solubility-and-%c2%b5f\/","title":{"rendered":"Solubilit\u00e9 et Microfluidique"},"content":{"rendered":"<p style=\"text-align: left;\"><a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.oprd.8b00300\"><code><\/code><code><\/code>Cette communication <\/a>\u00a0pr\u00e9sente un nouveau dispositif microfluidique de mesure de solubilit\u00e9 bas\u00e9 sur la g\u00e9n\u00e9ration de solutions satur\u00e9es \u00e0 partir de poudre et compatible avec tous types de solvants et de mol\u00e9cules. Cet appareil est simple et facile \u00e0 int\u00e9grer dans n&rsquo;importe quel laboratoire, m\u00eame ceux qui ne sont pas sp\u00e9cialis\u00e9s en microfluidique.<img decoding=\"async\" loading=\"lazy\" class=\"alignleft wp-image-5442 size-medium\" title=\"MESURE MICROFLUIDIQUE DE LA SOLUBILITE\" src=\"https:\/\/www.cinam.univ-mrs.fr\/cinam\/wp-content\/uploads\/2019\/04\/solubility_microfluidic-300x79.jpg\" alt=\"\" width=\"300\" height=\"79\" srcset=\"https:\/\/www.cinam.univ-mrs.fr\/cinam\/wp-content\/uploads\/2019\/04\/solubility_microfluidic-300x79.jpg 300w, https:\/\/www.cinam.univ-mrs.fr\/cinam\/wp-content\/uploads\/2019\/04\/solubility_microfluidic-768x203.jpg 768w, https:\/\/www.cinam.univ-mrs.fr\/cinam\/wp-content\/uploads\/2019\/04\/solubility_microfluidic-1024x271.jpg 1024w, https:\/\/www.cinam.univ-mrs.fr\/cinam\/wp-content\/uploads\/2019\/04\/solubility_microfluidic.jpg 1299w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/> Nous d\u00e9crivons la m\u00e9thode utilis\u00e9e pour mesurer la solubilit\u00e9, appliqu\u00e9e ici aux mol\u00e9cules pharmaceutiques parac\u00e9tamol et gliclazide dans diff\u00e9rents solvants. L&rsquo;appareil mesure rapidement la solubilit\u00e9 d&rsquo;un compos\u00e9 \u00e0 diverses temp\u00e9ratures allant de 20 \u00e0 60\u00b0C en utilisant des quantit\u00e9s extr\u00eamement faibles (ici, seulement 30 mg) de mati\u00e8re, avec une plage de concentration allant de mg\/mL \u00e0 des centaines de mg\/mL.<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Cette communication \u00a0pr\u00e9sente un nouveau dispositif microfluidique de mesure de solubilit\u00e9 bas\u00e9 sur la g\u00e9n\u00e9ration de solutions satur\u00e9es \u00e0 partir de poudre et compatible avec tous types de solvants et de mol\u00e9cules.<\/p>\n<p>Guillem Peybern\u00e8s, Romain Grossier, Fr\u00e9d\u00e9ric Villard, Philippe Letellier, Mehdi Lagaize, Nadine Candoni, St\u00e9phane Veesler<br \/>\nOrganic Process Research and Development 22:1856-1860 (2018)10.1021<\/p>\n","protected":false},"author":5,"featured_media":3772,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.cinam.univ-mrs.fr\/cinam\/wp-json\/wp\/v2\/posts\/4046"}],"collection":[{"href":"https:\/\/www.cinam.univ-mrs.fr\/cinam\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.cinam.univ-mrs.fr\/cinam\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.cinam.univ-mrs.fr\/cinam\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/www.cinam.univ-mrs.fr\/cinam\/wp-json\/wp\/v2\/comments?post=4046"}],"version-history":[{"count":24,"href":"https:\/\/www.cinam.univ-mrs.fr\/cinam\/wp-json\/wp\/v2\/posts\/4046\/revisions"}],"predecessor-version":[{"id":5613,"href":"https:\/\/www.cinam.univ-mrs.fr\/cinam\/wp-json\/wp\/v2\/posts\/4046\/revisions\/5613"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.cinam.univ-mrs.fr\/cinam\/wp-json\/wp\/v2\/media\/3772"}],"wp:attachment":[{"href":"https:\/\/www.cinam.univ-mrs.fr\/cinam\/wp-json\/wp\/v2\/media?parent=4046"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.cinam.univ-mrs.fr\/cinam\/wp-json\/wp\/v2\/categories?post=4046"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.cinam.univ-mrs.fr\/cinam\/wp-json\/wp\/v2\/tags?post=4046"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}