Romain Grossier

Axe

Sources et Sondes Ponctuelles

E-mail

romain.grossier@cnrs.fr

Phone

+33(0)6 62 92 28 79

Localisation

Grade

CRCN

Function

chercheur

Information
Publications

Activity

Nucleation / Crystallization / Microfluidics / Optical Microscopy / Image Processing

Themes

Milieu confiné

Nucléation

Publications

2024

Rapid Polymorphic Screening using Sessile Microdroplets: Competitive Nucleation of Mannitol Polymorphs

Ruel Cedeno, Romain Grossier, Nadine Candoni, Stéphane Veesler

CrystEngComm 26:5235-5240 (2024)10.1039/d4ce00648h

2023

CNT effective interfacial energy and pre-exponential kinetic factor from measured NaCl crystal nucleation time distributions in contracting microdroplets

Ruel Cedeno, Romain Grossier, Nadine Candoni, Nicolas Levernier, Adrian Flood, Stéphane Veesler

The Journal of Chemical Physics 158:194705 (2023)10.1063/5.0143704

Microdroplet Approach for Measuring Aqueous Solubility and Nucleation Kinetics of a Metastable Polymorph: The case of KDP Phase IV

Ruel Cedeno, Romain Grossier, Nadine Candoni, Stéphane Veesler

Crystal Growth & Design 23:9052-9057 (2023)10.1021/acs.cgd.3c01086

Modular microfluidic platform for solubility measurement, nucleation statistics and polymorph screening of active pharmaceutical ingredients: Irbesartan, Rimonabant, Aripiprazole and Sulfathiazole

Mathilde Lambert, Romain Grossier, Mehdi Lagaize, Thirou Bactivelane, Vasile Heresanu, Benoît Robert, Nadine Candoni, Stéphane Veesler

Journal of Crystal Growth 616:127252 (2023)

2022

Evaporation Dynamics of Sessile Saline Microdroplets in Oil

Ruel Cedeno, Romain Grossier, Victoria Tishkova, Nadine Candoni, Adrian E. Flood, Stéphane Veesler

Langmuir 38:9686-9696 (2022)10.1021/acs.langmuir.2c01269

Nucleation in Sessile Saline Microdroplets: Induction Time Measurement via Deliquescence-Recrystallization Cycling

Ruel Cedeno, Romain A Grossier, Mehdi Lagaize, D. Nerini, Nadine Candoni, A. E. Flood, Stéphane Veesler

Faraday Discussions 183-197 (2022)10.1039/D1FD00090J

2021

Preparation of alginate hydrogel microparticles by gelation introducing cross-linkers using droplet-based microfluidics: a review of methods

Cheng Zhang, Romain A Grossier, Nadine Candoni, Stéphane Veesler

Biomaterials Research 25:41 (2021)10.1186/s40824-021-00243-5

2020

Microfluidics platform for polymorph screening directly from powder

Guillem Peybernès, Romain Grossier, Frédéric Villard, Philippe Letellier, Nadine Candoni, Stéphane Veesler

Crystal Growth & Design 20:3882-3887 (2020)

A microfluidic method generating monodispersed microparticles with controllable sizes and mechanical properties

Cheng Zhang, Romain A Grossier, Leda Lacaria, Felix Rico, Nadine A Candoni, Stéphane A Veesler

Chemical Engineering Science 211:115322 (2020)10.1016/j.ces.2019.115322

2019

Advances in the Use of Microfluidics to Study Crystallization Fundamentals

Nadine A Candoni, Romain Grossier, Mehdi Lagaize, Stéphane Veesler

Annual Review of Chemical and Biomolecular Engineering 10:59-83 (2019)10.1146/annurev-chembioeng-060718-030312

2018

A chemical library to screen protein and protein-ligand crystallization using a versatile microfluidic platform

Charline J. J. Gerard, Gilles Ferry, Laurent M Vuillard, Jean A. Boutin, Nathalie A Ferte, Romain A Grossier, Nadine A Candoni, Stéphane A Veesler

Crystal Growth & Design 18:5130-5137 (2018)10.1021/acs.cgd.8b00572

A parameter to probe microdroplet dynamics and crystal nucleation

R. Grossier, Victoria Tishkova, R. Morin, S. Veesler

AIP Advances 8:075324 (2018)10.1063/1.5034443

Microfluidics set-up rapidly measures solubility directly from powder

Guillem Peybernès, Romain A Grossier, Frédéric Villard, Philippe Letellier, Mehdi Lagaize, Nadine A Candoni, Stéphane Veesler

Organic Process Research and Development 22:1856-1860 (2018)10.1021/acs.oprd.8b00300

2017

Crystallization via tubing microfluidics permits both in situ and ex situ X-ray diffraction

Charline J. J. Gerard, Gilles Ferry, Laurent M Vuillard, Jean A Boutin, Léonard M.G. Chavas, Tiphaine Huet, Nathalie A Ferte, Romain A Grossier, Nadine Candoni, Stéphane Veesler

Acta crystallographica Section F : Structural biology communications [2014-...] 73:574-578 (2017)10.1107/S2053230X17013826

Microfluidic platform for optimization of crystallization conditions

Shuheng A Zhang, Charline J. J. Gerard, Aziza A Ikni, Gilles Ferry, Laurent M Vuillard, Jean A. Boutin, Nathalie A Ferte, Romain A Grossier, Nadine A Candoni, Stéphane A Veesler

Journal of Crystal Growth 472:18-28 (2017)10.1016/j.jcrysgro.2017.01.026