Nadine Candoni

Axe

Sources et Sondes Ponctuelles

E-mail

nadine.candoni@univ-amu.fr

Phone

+33(0)6 17 24 80 87

Localisation

Grade

PU1

Function

enseignant - chercheur

Room

313

Information
Publications

Activity

microfluidique, cristallisation, gélification, nucléation, croissance, biologique, biomédical, AFM ; physico-chimie/surface ; nanoparticules ; biomolécules : ADN, protéines ; jonction brisée : or, molécule unique ; hydrodynamique ; mouillage

Themes

RESEARCH INTERESTS AND ACTIVITIES

13 Thesis and Master2 internships

45 publications including 1 patent, 2 ANR projects and 2 CIFRE contracts

50 international and national conferences including 17 as a guest speaker

2009- Reactions in nanovolumes using droplet-based microfluidic systems :

Crystallization studies for pharmaceutical and biological applications
Jellification to mimic red blood cells for biomedical applications

2007-2012 Conductance measurement on single molecules

2000-2007 AFM and Colorimetric Detection of DNA hybridization (ex-GPEC)

1998 - 2000 Physico-chemical studies of viscous pulverizations (Renault)

1995-1998 Forced Dynamic wetting of agrochemical emulsions(CNRS/Rhodia)

Recherche

RESEARCH INTERESTS AND ACTIVITIES since 2009

Development of droplet-based microfluidic systems tu study reactions in nanovolumes :

Crystallization studies for pharmaceutical and biological applications
Jellification to mimic red blood cells for biomedical applications

Parcours

CAREER: CNU -28ème section “Milieux denses et Matériaux”

2018- Full Professor 1^st class, Polytech-Aix-Marseille Université / CINaM

2015- Head of the Dept of Biomedical Engineering-Polytech Marseille

2013-2018 Full Professor 2^nd class, Polytech-Aix-Marseille Université / CINaM

2000-2013 Assistant Professor Polytech-Aix-Marseille Université / CINaM

1998-2000 Post-Doc - CNRS & Company Renault

1995-1998 PhD Thesis - Lab. of Transport Phenomena in Mixed Media / CNRS

EDUCATION

2010 Habilitation Thesis : “Detection and physico-chemistry of single objects”

1998 PhD thesis : “Forced Dynamic wetting of agrochemical emulsions”

1993-1994 Master Degree in Condensed Matter - Paris VI

1989-1992 Engineer in Physics and Chemistry-Engineering School of Bordeaux

Publications

2024

Rapid Polymorphic Screening using Sessile Microdroplets: Competitive Nucleation of Mannitol Polymorphs

Ruel Cedeno, Romain Grossier, Nadine Candoni, Stéphane Veesler

CrystEngComm 26:5235-5240 (2024)10.1039/d4ce00648h

2023

Exploring the World of Membrane Proteins: Techniques and Methods for Understanding Structure, Function, and Dynamics

Imad Boulos, Joy Jabbour, Serena Khoury, Nehme Mikhael, Victoria Tishkova, Nadine Candoni, Hilda E Ghadieh, Stéphane Veesler, Youssef Bassim, Sami Azar, Frédéric Harb

Molecules 28:7176 (2023)10.3390/molecules28207176

CNT effective interfacial energy and pre-exponential kinetic factor from measured NaCl crystal nucleation time distributions in contracting microdroplets

Ruel Cedeno, Romain Grossier, Nadine Candoni, Nicolas Levernier, Adrian Flood, Stéphane Veesler

The Journal of Chemical Physics 158:194705 (2023)10.1063/5.0143704

Microdroplet Approach for Measuring Aqueous Solubility and Nucleation Kinetics of a Metastable Polymorph: The case of KDP Phase IV

Ruel Cedeno, Romain Grossier, Nadine Candoni, Stéphane Veesler

Crystal Growth & Design 23:9052-9057 (2023)10.1021/acs.cgd.3c01086

Modular microfluidic platform for solubility measurement, nucleation statistics and polymorph screening of active pharmaceutical ingredients: Irbesartan, Rimonabant, Aripiprazole and Sulfathiazole

Mathilde Lambert, Romain Grossier, Mehdi Lagaize, Thirou Bactivelane, Vasile Heresanu, Benoît Robert, Nadine Candoni, Stéphane Veesler

Journal of Crystal Growth 616:127252 (2023)

2022

Evaporation Dynamics of Sessile Saline Microdroplets in Oil

Ruel Cedeno, Romain Grossier, Victoria Tishkova, Nadine Candoni, Adrian E. Flood, Stéphane Veesler

Langmuir 38:9686-9696 (2022)10.1021/acs.langmuir.2c01269

Nucleation in Sessile Saline Microdroplets: Induction Time Measurement via Deliquescence-Recrystallization Cycling

Ruel Cedeno, Romain A Grossier, Mehdi Lagaize, D. Nerini, Nadine Candoni, A. E. Flood, Stéphane Veesler

Faraday Discussions 183-197 (2022)10.1039/D1FD00090J

2021

Preparation of alginate hydrogel microparticles by gelation introducing cross-linkers using droplet-based microfluidics: a review of methods

Cheng Zhang, Romain A Grossier, Nadine Candoni, Stéphane Veesler

Biomaterials Research 25:41 (2021)10.1186/s40824-021-00243-5

2020

Microfluidics platform for polymorph screening directly from powder

Guillem Peybernès, Romain Grossier, Frédéric Villard, Philippe Letellier, Nadine Candoni, Stéphane Veesler

Crystal Growth & Design 20:3882-3887 (2020)

A microfluidic method generating monodispersed microparticles with controllable sizes and mechanical properties

Cheng Zhang, Romain A Grossier, Leda Lacaria, Felix Rico, Nadine A Candoni, Stéphane A Veesler

Chemical Engineering Science 211:115322 (2020)10.1016/j.ces.2019.115322

2019

Advances in the Use of Microfluidics to Study Crystallization Fundamentals

Nadine A Candoni, Romain Grossier, Mehdi Lagaize, Stéphane Veesler

Annual Review of Chemical and Biomolecular Engineering 10:59-83 (2019)10.1146/annurev-chembioeng-060718-030312

Multiscale Experimental Study and Modeling of l -Glutamic acid Crystallization: Emphasis on a Kinetic Explanation of the Ostwald Rule of Stages

Yousra Tahri, Emilie Gagnière, Elodie Chabanon, Tijani Bounahmidi, Zdeněk Kožíšek, Nadine Candoni, Stéphane Veesler, Moussa Boukerche, Denis Mangin

Crystal Growth & Design 19:3329-337 (2019)10.1021/acs.cgd.9b00217

2018

A chemical library to screen protein and protein-ligand crystallization using a versatile microfluidic platform

Charline J. J. Gerard, Gilles Ferry, Laurent M Vuillard, Jean A. Boutin, Nathalie A Ferte, Romain A Grossier, Nadine A Candoni, Stéphane A Veesler

Crystal Growth & Design 18:5130-5137 (2018)10.1021/acs.cgd.8b00572

Microfluidics set-up rapidly measures solubility directly from powder

Guillem Peybernès, Romain A Grossier, Frédéric Villard, Philippe Letellier, Mehdi Lagaize, Nadine A Candoni, Stéphane Veesler

Organic Process Research and Development 22:1856-1860 (2018)10.1021/acs.oprd.8b00300

2017

Crystallization via tubing microfluidics permits both in situ and ex situ X-ray diffraction

Charline J. J. Gerard, Gilles Ferry, Laurent M Vuillard, Jean A Boutin, Léonard M.G. Chavas, Tiphaine Huet, Nathalie A Ferte, Romain A Grossier, Nadine Candoni, Stéphane Veesler

Acta crystallographica Section F : Structural biology communications [2014-...] 73:574-578 (2017)10.1107/S2053230X17013826

Microfluidic platform for optimization of crystallization conditions

Shuheng A Zhang, Charline J. J. Gerard, Aziza A Ikni, Gilles Ferry, Laurent M Vuillard, Jean A. Boutin, Nathalie A Ferte, Romain A Grossier, Nadine A Candoni, Stéphane A Veesler

Journal of Crystal Growth 472:18-28 (2017)10.1016/j.jcrysgro.2017.01.026

2016

Factors affecting the viscosity of sodium hypochlorite and their effect on irrigant flow

F. Bukiet, T. Soler, M. Guivarc'H, J. Camps, H. Tassery, F. Cuisinier, N. Candoni

International Endodontic Journal 49:912 (2016)10.1111/iej.12673

2014

Transient calcium carbonate hexahydrate (Ikaite) nucleated and stabilized in confined nano- and picovolumes

I. Rodríguez-Ruiz, S. Veesler, J. Gómez-Morales, J.M. Delgado-López, O. Grauby, Z. Hammadi, N. Candoni, J.M. García-Ruiz

Crystal Growth & Design 14:792-802 (2014)