Annie Viallat

Axe

Physique et nano-micro Ingénierie pour le Vivant

E-mail

viallat@cinam.univ-mrs.fr

Phone

+33(0)6 83 09 25 74

Fax

+33(0)4 91 41 89 16

Localisation

TPR1 - 3 étage

Grade

DR1

Function

chercheur

Room

G.03.24

viallat.jpg

Activity

biological physics –Fluid and elasticity in cells - Membranes – cell rheology

Themes

 

Current Research Area : Active Matter - Biofluid Physics – Fluid and elasticity in living systems

 

Soft micro-shells, artificial capsules, liposomes, encapsulation.

Red blood cells dynamics in flow: Lift force – Cell Biomechanics –Sedimentation – fluid structure interaction

Blood cell Dynamics in the microvasculature: Microfluidics- red blood cells in submicron splenic slits - vasoocclusion in sickle cell anemia, blood cells adhesion and margination 

Physics of the mucociliary transport:  collective behaviour of bronchial cilia, flow patterns, coupling between ciliary activity and mucus transport

 

 

Recherche

 Soft micro-shells, micro-beads, liposomes, encapsulation

                          Viscous and Gelly giant vesicles – Standards for comet assays – Artificial vacuoles for living parasites

GUV and Red blood cells dynamics in flow

                          Lift force – Cell Biomechanics –Sedimentation -

Red and White Blood Cells Dynamics in biomimicking capillary networks

                          Microfluidics – Cell Rheology – Transport in the Vasculature

Artifical vacuoles for Leishmania

Severe asthma: physicial aspects of the mucociliary transport

            Microrheology – cilia beats– application for severe asthma

 

Parcours

Biography

Annie Viallat is engineer of Ecole Polytechnique (Paris, France). She received her PhD in Physics from the University of Grenoble (France) in 1987, working on polymer gels and NMR. After a postdoc on theory of conjugated polymers in the Materials Departments (UC Santa Barbara), she joined the Spectrométrie Physique lab (Grenoble) in 1989, studying polymer gels and heterogeneous polymer solutions. Her research moved to biological physics in 1999. From 2005 to 2015 she led a group in Marseille on the dynamics in microflows of vesicles and blood cells. Since 2016, she is the head of department ‘Physics and Engineering for Living Matter’ in CINaM (Marseille), working on active matter, microcirculation of red blood cells in disease and physics of the mucociliary clearance.

 

 

Positions

2016-  Head of department at CINaM Physics and nano/micro engineering of living systems,

2007-2014 Director of the CNRS French Consortium ‘Physics from Cell to Tissue’

2005-2015 Group leader ‘biomimetics’, Adhesion & Inflammation lab., Marseille Biophysics-Biomechanics

1999-2002 Group Leader, Laboratoire Spectrométrie Physique, Grenoble, Polymers, Giant Lipid vesicles

1989-1999 Junior Research Scientist, Laboratoire Spectrométrie Physique, Grenoble

 

Academic degrees

1982 Engineer Ecole Polytechnique, Paris 
1984 Engineer: Rural Eng., Water, Paris 

1984 Master in Solid State Physics, Paris 7

 

Awards: PhD fellowship Rhône Poulenc (1985), Postdoc fellowship UCSB, Material Department (1988), PES CNRS 2010-2013,

Grants: 2002 IPMC Grenoble, 2003 Region RhôneAlpes, 2004 CPER RhôneAlpes, 2004 PIR microfluidique, 204 AC CNRS, 2004 IT2B, 2009 ANR, 2010 PACA region, 2010 C’Nano PACA, 2011 CNRS prise de risque,  2011 CAPES-COFECUB program, 2013 ANR, 2013 AMidex*

Management-expertise: ANR (France), NSF (USA), FET program (European Commission), Comité National (CNRS), CNU, AERES

 

 

Publications

2020

Mechanical adaptation of monocytes in model lung capillary networks

Jules Dupire, Pierre-Henri Puech, Emmanuèle Helfer, Annie Viallat

Proceedings of the National Academy of Sciences of the United States of America (2020)

Hydrodynamic model of directional ciliary-beat organization in human airways

Simon Gsell, Etienne Loiseau, Umberto D’ortona, Annie Viallat, Julien Favier

Scientific Reports 10 (2020)10.1038/s41598-020-64695-w

Active mucus–cilia hydrodynamic coupling drives self-organization of human bronchial epithelium

Etienne Loiseau, Simon Gsell, Aude Nommick, Charline Jomard, Delphine Gras, Pascal Chanez, Umberto D’ortona, Laurent Kodjabachian, Julien Favier, Annie Viallat

Nature Physics (2020)10.1038/s41567-020-0980-z

2019

Self-organization of red blood cell suspensions under confined 2D flows

Cécile Iss, Dorian Midou, Alexis Moreau, Delphine Held, Anne Charrier, Simon Mendez, Annie Viallat, Emmanuèle Helfer

Soft Matter (2019)10.1039/C8SM02571A

2018

Spatiotemporal organization of cilia drives multiscale mucus swirls in model human bronchial epithelium

Mustapha-Kamel Khelloufi, Etienne Loiseau, Marc Jaeger, Nicolas Molinari, Pascal Chanez, Delphine Gras, Annie Viallat

Scientific Reports 8:2447 (2018)10.1038/s41598-018-20882-4

When giant vesicles mimic red blood cell's dynamics: swinging of two-phase vesicles in shear flow

Simon Tusch, Etienne Loiseau, Al-Hair Al-Halifa, Kamel Khelloufi, Emmanuèle Helfer, Annie Viallat

Physical Review Fluids 3 (2018)10.1103/PhysRevFluids.3.123605

2017

High Aspect Ratio Sub-Micrometer Channels Using Wet Etching: Application to the Dynamics of Red Blood Cell Transiting through Biomimetic Splenic Slits

Priya Gambhire, Scott Atwell, Cécile Iss, Frédéric Bedu, Igor Ozerov, Catherine Badens, Emmanuèle Helfer, Annie Viallat, Anne Charrier

Small 13:1700967 (2017)10.1002/smll.201700967

2015

Encapsulation of Living Leishmania Promastigotes in Artificial Lipid Vacuoles

Carlos E. S. Guedes, Jose G. B. Lima, Emmanuèle Helfer, Patricia S. T. Veras, Annie Viallat

PLoS ONE 1-12 (2015)10.1371/journal.pone.0134925

Serum Pantetheinase/Vanin Levels Regulate Erythrocyte Homeostasis and Severity of Malaria

Samuel Rommelaere, Virginie Millet, Pascal Rihet, Scott Atwell, Emmanuèle Helfer, Lionel Chasson, Carole Beaumont, Giovanna Chimini, Maria Do Rosario Sambo, Annie Viallat, Carlos Penha-Goncalves, Franck Galland, Philippe Naquet

American Journal of Pathology 185:3039-3052 (2015)10.1016/j.ajpath.2015.07.011

2014

Vesicle adhesion visualized with total internal reflection imaging ellipsometry biosensor

Li Liu, Annie Viallat, Gang Jin

Sensors and Actuators B: Chemical 190:221-226 (2014)

Red blood cell: from its mechanics to its motion in shear flow

A. Viallat, M. Abkarian

International Journal of Laboratory Hematology 36:237-243 (2014)10.1111/ijlh.12233

2013

La dynamique des globules rouges sous écoulement

Annie Viallat, Jules Dupire, Marius Socol

médecine/sciences 29:468-470 (2013)

2012

Full dynamics of a red blood cell in shear flow

J. Dupire, M. Socol, A. Viallat

Proceedings of the National Academy of Sciences of the United States of America 109:20808-20813 (2012)

Gel Phase Vesicles Buckle into Specific Shapes

François Quemeneur, Catherine Quilliet, Magalie Faivre, Annie Viallat, Brigitte Pepin-Donat

Physical Review Letters 108 (2012)10.1103/physrevlett.108.108303

Gel-phase vesicles buckle into specific shapes

François Quéméneur, Catherine Quilliet, Magalie Faivre, Annie Viallat, Brigitte Pépin-Donat

Physical Review Letters 108:108303 (2012)

2011

Sedimentation of vesicles: from pear-like shapes to microtether extrusion

Huang Zen-Hong, Manouk Abkarian, Annie Viallat

New Journal of Physics 13:035026 (2011)10.1088/1367-2630/13/3/035026

2010

Chaotic Dynamics of Red Blood Cells in a Sinusoidal Flow

Jules Dupire, Manouk Abkarian, Annie Viallat

Physical Review Letters 104:168101 (2010)10.1103/PhysRevLett.104.168101

Sensitive detection of ultra-weak adhesion states of vesicles by interferometric microscopy

Huang Zen-Hong, Gladys Massiera, Laurent Limozin, Paul Boullanger, Valignat Marie-Pierre, Annie Viallat

Soft Matter 6:1948 (2010)10.1039/b925373d

2008

vesicles and red blood cells in shear flow

Manouk Abkarian, Annie Viallat

Soft Matter 4:653 (2008)10.1039/b716612e

Nanotubes from gelly vesicles

S. Kremer, Clément Campillo, B. Pepin-Donat, A. Viallat, F. Brochard-Wyart

EPL - Europhysics Letters 82:48002 (2008)10.1209/0295-5075/82/48002

Nanotubes from gelly vesicles

Annie Viallat, Clément Campillo, Brigitte Pepin-Donat, Françoise Brochard-Wyart, Sebastien Kremer

EPL - Europhysics Letters 82:48002 (2008)10.1209/0295-5075/82/48002

2007

Swinging of Red Blood Cells under Shear Flow

Manouk Abkarian, Magalie Faivre, Annie Viallat

Physical Review Letters 98 (2007)10.1103/physrevlett.98.188302

2006

Responsive Giant Vesicles filled with Poly(N-isopropylacrylamide) Sols or Gels

Magalie Faivre, Clément Campillo, B. Pepin-Donat, Annie Viallat

Progress in Colloid and Polymer Science 133:41 (2006)10.1007/2882_050

Dynamics of viscous vesicles in shear flow

M. -A. Mader, V. Vitkova, M. Abkarian, A. Viallat, T. Podgorski

European Physical Journal E: Soft matter and biological physics 19:389-397 (2006)10.1140/epje/i2005-10058-x

Electromechanical Polymer Gels Combining Rubber Elasticity with Electronic Conduction

B. Pepin-Donat, A. Viallat, J.-F. Blachot, C. Lombard

Advanced Materials 18:1401-1405 (2006)