Ling Peng

Axe

Ingénierie Moléculaire et Matériaux Fonctionnels

E-mail

ling.peng@univ-amu.fr

Phone

+33(0)6 17 24 81 64

Fax

+33(0)4 91 82 93 01

Localisation

TPR1 - 4 étage

Grade

DR1

Fonction

chercheur

peng.jpg

Activité

dendrimers, drug delivery, nanobiotechnology, nanomedicine

Thèmes

1. Intelligent functional biomaterials based on dendrimer nanotechnology  

2. Molecular probes and chemical biology

3. Drug discovery based on triazole nucleoside chemistry

 

Recherche

Functional and intelligent biomaterials based on dendrimer nanotechnology: In order to treat various life-threatening diseases such as cancer, infection and neurodegenerative dementia, it is essential to develop efficient systems which enable precise diagnosis and effective treatment of diseases by delivering the right agents at the right sites with the right doses and timing. Dendrimers are the ideal delivery systems by virtue of their uniquely well-defined and precisely controlled structure with multivalent cooperativity confined within a nanosized volume. We are developing functional biocompatible dendrimer materials for bioimaging-based diagnosis, cancer treatment and gene therapy.

Molecular probes and chemical biology: Molecular probes are useful tools to study and understand biological events. We have designed and synthesized various molecular probes of phospholipids and of 2-oxoglutarate, an important intermediate of the Kreb’s cycle, with a view to studying biomembranes and the signaling roles and pathways of Kreb’s cycle intermediates in nitrogen fixation and cancer development.

Drug discovery based on triazole nucleoside chemistry: Nucleoside mimics are of great importance in the search for antiviral, anticancer and antibacterial drug candidates. One noteworthy example is ribavirin, the first synthetic triazole nucleoside showing antiviral activity against a broad spectrum of viruses. We have developed novel triazole nucleoside derivatives using modern green chemistry. Some of the lead compounds have shown excellent potency against drug-resistant cancers with novel modes of action such as targeting the heat shock response pathway, inducing autophagy and eliciting an immunomodulation effect etc.

 

Parcours

Dr. Ling Peng is a research director at the French National Scientific Research Center (CNRS). She carried her undergraduate study in polymer chemistry with Prof. Chen Rongshi at Nanjing University in China, her PhD program in organic chemistry with Prof. Albert Eschenmoser at Swiss Federal Institute of Technology in Zurich in Switzerland, and her postdoctoral research in Pharmacy with Prof. Maurice Goeldner at Louis Pasteur University of Strasbourg in France. She was recruited as a research scientist in CNRS in 1997, and promoted as a CNRS research director in 2008. She is currently a group leader at the Interdisciplinary Center on Nanoscience in Marseille (CINaM) in France, and working actively in developing multifunctional dendrimers as intelligent nanomaterials for drug and gene delivery, molecular probes for exploring biological events and drug discovery. She has co-authored more than 100 scientific papers, 6 patents and 15 book chapters. Dr. Ling Peng has also coordinated and participated in different European projects. Her research team has been labelled by La Ligue Contre le Cancer in France since 2016, and she was awarded with the Prize of Dr and Mrs Henri Labbé of the French Academy of Sciences in 2017.    

Selected Publications:

1.     Garrigue P, Tang J, Ding L, Bouhlel A, Tintaru A, Laurini E, Huang Y, Lyu Z, Zhang M, Fernandez S, Balasse L, Lan W, Mas E, Marson D, Weng Y, Liu X, Giorgio S, Iovanna J, Pricl S, Guillet B, Peng LSelf-assembling supramolecular dendrimer nanosystem for PET imaging of tumors”, Proc. Natl. Acad. Sci. USA, 2018, 115, 11454

2.     Dong Y, Yu T, Ding L, Laurini E, Huang Y, Zhang M, Weng Y, Lin S, Chen P, Marson D, Jiang Y, Giorgio S, Pricl S, Liu X, Rocchi P, Peng L, “A dual targeting dendrimer-mediated siRNA delivery system for effective gene silencing in cancer therapy”, J. Am. Chem. Soc. 2018140, 16264 (cover)

3.     Zhou ZCong M, Li M, Tintaru A, Li J, Yao J, Xia Y, Peng L, “Negative dendritic effect on enzymatic hydrolysis of dendrimer conjugates”, Chem. Commun. 201854, 5956 (inside front cover)

4.     Lyu Z, Peng L“Potent drugless dendrimers”, Nat. Biomed. Eng. 20171, 686

5.     Hinman S, Ruiz C, Cao Y, Ma M, Tang J, Laurini E, Posocco P, Pricl S, Giorgio S, Peng L, Cheng Q, “Mix and Match: co-assembly of amphiphilic dendrimers and phospholipids creates robust, modular and controllable interfaces”, ACS Appl. Mater. Interfaces20179, 1029

6.     Liu X, Wang Y, Chen C, Tintaru A, Cao Y, Liu J, Ziarelli F, Tang J, Guo H, Rosas R, Giorgio S, Charles L, Rocchi P, Peng L, “A fluorinated bola-amphiphilic dendrimer for on-demand delivery of siRNA via specific response to reactive oxygen species”, Adv. Funct. Mater. 201626, 8594 (cover)

7.     Wei T, Chen C, Liu J, Liu C, Posocco P, Liu X, Cheng Q, Huo S, Liang Z, Fermeglia M, Pricl S, Liang XJ, Rocchi P, Peng L, “Anticancer drug nanomicelles formed by self-assembling amphiphilic dendrimer to combat cancer drug resistance”, Proc. Natl. Acad. Sci. USA, 2015112, 2978

8.     Liu X, Zhou J, Yu T, Chen C, Cheng Q, Sengupta K, Huang Y, Li H, Liu C, Wang Y, Posocco P, Wang M, Cui Q, Giorgio S, Fermeglia M, Qu F, Pricl S, Shi Y, Liang Z, Rocchi P, Rossi JJ, Peng L, “Adaptive amphiphilic dendrimer based nanoassemblies as robust and versatile siRNA delivery systems”, Angew. Chem. Int. Ed. 201453, 11822 (Highlighted in Nature Chemistry)

9.     Fan Y, Cong M, Peng L, “Mixed ligand catalyst: a powerful tool in transition metal-catalyzed cross-coupling reactions”, Chem. Eur. J. 201420, 2698-2702. (Frontiespiece)

10.   Xia Y, Peng L, “Photoactivatable Lipid Probes for Studying Biomembranes by Photoaffinity Labeling”, Chem. Rev2013113, 7880 (Cover story).

11.   Chen H, Viel S, Ziarelli F, Peng L, “19F NMR: a valuable tool for studying biological events”, Chem. Soc. Rev2013427971 (Back Cover)

12.   Xia Y, Wang M, Demaria O, Tang J, Rocchi P, Qu F, Iovanna JL, Alexopoulou L, Peng L, "A novel bitriazoyl acyclonucleoside endowed with dual antiproliferative and immunomodulatory activity", J. Med. Chem. 201255, 5642

13.   Yu T, Liu X, Bolcato-Bellemin A-L, Wang Y, Liu C, Erbacher P, Qu F, Rocchi P, Behr J-P, Peng L, "An amphiphilic dendrimer for effective siRNA delivery and gene silencing in vitro and in vivo", Angew. Chem. Int. Ed. 2012518478 (Frontispiece)

14.  Zhou J, Wu J, Hafdi N, Behr J-P, Erbacher P, Peng L, "PAMAM dendrimers for efficient siRNA delivery and potent gene silencing", Chem. Commun. 20062362 (Hot Paper)

15. Laurent S, Chen H, Bedu S, Ziarelli F, Peng LZhang C-C, "Nonmetabolizable analogue of 2-oxoglutarate elicits heterocyst differentiation under repressive conditions in Anabaena sp. PCC 7120", Proc. Natl. Acad. Sci. USA 2005102, 9907 (Cover story)

 

 

Publications

2020

Synthesis and use of an amphiphilic dendrimer for siRNA delivery into primary immune cells

Jiaxuan Chen, Aleksandra Ellert-Miklaszewska, Stefano Garofalo, Arindam Dey, Jingjie Tang, Yifan Jiang, Flora Clément, Patrice Marche, Xiaoxuan Liu, Bozena Kaminska, Angela Santoni, Cristina Limatola, John Rossi, Jiehua Zhou, Ling Peng

Nature Protocols (2020)10.1038/s41596-020-00418-9

An ionizable supramolecular dendrimer nanosystem for effective siRNA delivery with a favorable safety profile

Dinesh Dhumal, Wenjun Lan, Ling Ding, Yifan Jiang, Zhenbin Lyu, Erik Laurini, Domenico Marson, Aura Tintaru, Nelson Dusetti, Suzanne Giorgio, Juan Lucio Iovanna, Sabrina Pricl, Ling Peng

Nano Research (2020)10.1007/s12274-020-3216-8

A self-assembling amphiphilic dendrimer nanotracer for SPECT imaging

Ling Ding, Zhenbin Lyu, Aura Tintaru, Erik Laurini, Domenico Marson, Beatrice Louis, Ahlem Bouhlel, Laure Balasse, Samantha Fernandez, Philippe Garrigue, Eric Mas, Suzanne Giorgio, Sabrina Pricl, Benjamin Guillet, Ling Peng

Chemical Communications 56:301-304 (2020)10.1039/c9cc07750b

Surface Charge of Supramolecular Nanosystems for In Vivo Biodistribution: A MicroSPECT/CT Imaging Study

Ling Ding, Zhenbin Lyu, Beatrice Louis, Aura Tintaru, Erik Laurini, Domenico Marson, Mengjie Zhang, Wanxuan Shao, Yifan Jiang, Ahlem Bouhlel, Laure Balasse, Philippe Garrigue, Eric Mas, Suzanne Giorgio, Juan Iovanna, Yuanyu Huang, Sabrina Pricl, Benjamin Guillet, Ling Peng

Small 16:301-304 (2020)10.1002/smll.202003290

Natural killer cells modulate motor neuron-immune cell cross talk in models of Amyotrophic Lateral Sclerosis

Stefano Garofalo, Germana Cocozza, Alessandra Porzia, Maurizio Inghilleri, Marcello Raspa, Ferdinando Scavizzi, Eleonora Aronica, Giovanni Bernardini, Ling Peng, Richard Ransohoff, Angela Santoni, Cristina Limatola

Nature Communications 11:1773 (2020)10.1038/s41467-020-15644-8

Therapeutic siRNA: state of the art

Bo Hu, Liping Zhong, Yuhua Weng, Ling Peng, Yuanyu Huang, Yongxiang Zhao, Xing-Jie Liang

Signal Transduction and Targeted Therapy 5 (2020)10.1038/s41392-020-0207-x

Liver Activation of Hepatocellular Nuclear Factor-4α by Small Activating RNA Rescues Dyslipidemia and Improves Metabolic Profile

Kai-Wen Huang, Vikash Reebye, Katherine Czysz, Simona Ciriello, Stephanie Dorman, Isabella Reccia, Hong-Shiee Lai, Ling Peng, Nikos Kostomitsopoulos, Joanna Nicholls, Robert Habib, Donald Tomalia, Pål Sætrom, Edmund Wilkes, Pedro Cutillas, John Rossi, Nagy Habib

Molecular Therapy - Nucleic Acids 19:361-370 (2020)10.1016/j.omtn.2019.10.044

Targeting NUPR1 with the small compound ZZW-115 is an efficient strategy to treat hepatocellular carcinoma

Wenjun Lan, Patricia Santofimia-Castaño, Yi Xia, Zhengwei Zhou, Can Huang, Nicolas Fraunhoffer, Dolores Barea, Melchiore Cervello, Lydia Giannitrapani, Giuseppe Montalto, Ling Peng, Juan Iovanna

Cancer Letters 486:8-17 (2020)10.1016/j.canlet.2020.04.024

ZZW-115-dependent inhibition of NUPR1 nuclear translocation sensitizes cancer cells to genotoxic agents

Wenjun Lan, Patricia Santofimia-Castaño, Mirna Swayden, Yi Xia, Zhengwei Zhou, Stéphane Audebert, Luc Camoin, Can Huang, Ling Peng, Ana Jiménez-Alesanco, Adrián Velázquez-Campoy, Olga Abián, Gwen Lomberk, Raul Urrutia, Bruno Rizzuti, Vincent Geli, Philippe Soubeyran, José Neira, Juan Iovanna

JCI Insight 5 (2020)10.1172/jci.insight.138117

Novel Aryltriazole Acyclic C-Azanucleosides as Anticancer Candidates

Yanhua Zhang, Yun Lin, Qianqian Hou, Xi Liu, Sabrina Pricl, Ling Peng, Yi Xia

Organic and Biomolecular Chemistry (2020)10.1039/d0ob02164d

Novel triazole nucleoside analogues promote anticancer activity via both apoptosis and autophagy

Yanhua Zhang, Xi Liu, Yun Lin, Baoping Lian, Wenjun Lan, Juan Iovanna, Xiaoxuan Liu, Ling Peng, Yi Xia

Chemical Communications 56:10014-10017 (2020)10.1039/d0cc04660d

2019

Efficient and innocuous delivery of small interfering RNA to microglia using an amphiphilic dendrimer nanovector

Aleksandra Ellert-Miklaszewska, Natalia Ochocka, Marta Maleszewska, Ling Ding, Erik Laurini, Yifan Jiang, Adria-Jaume Roura, Suzanne Giorgio, Bartlomiej Gielniewski, Sabrina Pricl, Ling Peng, Bozena Kaminska

Nanomedicine 14:2441-2458 (2019)10.2217/nnm-2019-0176

Poly(amidoamine) dendrimers: covalent and supramolecular synthesis

Z. Lyu, L. Ding, A.Y.T. Huang, L. Kao, Ling Peng

Materials Today Chemistry 13:34-48 (2019)10.1016/j.mtchem.2019.04.004

Designing and repurposing drugs to target intrinsically disordered proteins for cancer treatment: using NUPR1 as a paradigm

Patricia Santofimia-Castaño, Bruno Rizzuti, Yi Xia, Olga Abián, Ling Peng, Adrián Velázquez-Campoy, Juan Iovanna, José Neira

Molecular & Cellular Oncology 1-3 (2019)10.1080/23723556.2019.1612678

Ligand-based design identifies a potent NUPR1 inhibitor exerting anticancer activity via necroptosis

Patricia Santofimia-Castaño, Yi Xia, Wenjun Lan, Zhengwei Zhou, Can Huang, Ling Peng, Philippe Soubeyran, Adrián Velázquez-Campoy, Olga Abián, Bruno Rizzuti, José Neira, Juan Iovanna

Journal of Clinical Investigation 129:2500-2513 (2019)10.1172/jci127223

Targeting intrinsically disordered proteins involved in cancer

Patricia Santofimia-Castaño, Bruno Rizzuti, Yi Xia, Olga Abián, Ling Peng, Adrián Velázquez-Campoy, José Neira, Juan Iovanna

Cellular and Molecular Life Sciences (2019)10.1007/s00018-019-03347-3

Targeting the Stress-Induced Protein NUPR1 to Treat Pancreatic Adenocarcinoma

Patricia Santofimia-Castaño, Yi Xia, Ling Peng, Adrián Velázquez-Campoy, Olga Abián, Wenjun Lan, Gwen Lomberk, Raul Urrutia, Bruno Rizzuti, Philippe Soubeyran, José Luis Neira, Juan Iovanna

Cells 8:1453 (2019)10.3390/cells8111453

Flavonoid–alkylphospholipid conjugates elicit dual inhibition of cancer cell growth and lipid accumulation

Zhengwei Zhou, Biyao Luo, Xi Liu, Mimi Chen, Wenjun Lan, Juan Iovanna, Ling Peng, Yi Xia

Chemical Communications 55:8919-8922 (2019)10.1039/c9cc04084f

2018

Dendrimer-based magnetic resonance imaging agents for brain cancer

Ling Ding, Zhenbin Lyu, Dinesh Dhumal, Chai-Lin Kao, Monique Bernard, Ling Peng

Science China Materials 61:1420-1443 (2018)

Dendrimer-based magnetic resonance imaging agents for brain cancer

Ling Ding, Zhenbin Lyu, Dinesh Dhumal, Chai-Lin Kao, Monique Bernard, Ling Peng

Science China Materials 61:1420-1443 (2018)10.1007/s40843-018-9323-6

A Dual Targeting Dendrimer-Mediated siRNA Delivery System for Effective Gene Silencing in Cancer Therapy

Yiwen Dong, Tianzhu Yu, Ling Ding, Erik Laurini, Yuanyu Yu, Mengjie Zhang, Yuhua Yu, Shuting Lin, Peng Chen, Domenico Marson, Yifan Jiang, Suzanne Giorgio, Sabrina Pricl, Xiaoxuan Jiang, Palma Rocchi, Ling Peng

Journal of the American Chemical Society 140:16264-16274 (2018)10.1021/jacs.8b10021

A Dual Targeting Dendrimer-Mediated siRNA Delivery System for Effective Gene Silencing in Cancer Therapy

Yiwen Dong, Tianzhu Yu, Ling Ding, Erik Laurini, Yuanyu Huang, Mengjie Zhang, Yuhua Weng, Shuting Lin, Peng Chen, Domenico Marson, Yifan Jiang, Suzanne Giorgio, Sabrina Pricl, Xiaoxuan Liu, Palma Rocchi, Ling Peng

Journal of the American Chemical Society 140:16264-16274 (2018)10.1021/jacs.8b10021

E2F signature is predictive for the pancreatic adenocarcinoma clinical outcome and sensitivity to E2F inhibitors, but not for the response to cytotoxic-based treatments

Wenjun Lan, Benjamin Bian, Yi Xia, Samir Dou, Odile Gayet, Martin Bigonnet, Patricia Santofimia-Castaño, Mei Cong, Ling Peng, Nelson Dusetti, Juan Iovanna

Scientific Reports 8:8330 (2018)10.1038/s41598-018-26613-z

Blocking Stemness and Metastatic Properties of Ovarian Cancer Cells by Targeting p70S6K with Dendrimer Nanovector-Based siRNA Delivery

Jing Ma, Shashwati Kala, Susan Yung, Tak Mao Chan, Yu Cao, Yifan Jiang, Xiaoxuan Liu, Suzanne Giorgio, Ling Peng, Alice S.T. Wong

Molecular Therapy 26:70-83 (2018)10.1016/j.ymthe.2017.11.006

Blocking Stemness and Metastatic Properties of Ovarian Cancer Cells by Targeting p70S6K with Dendrimer Nanovector-Based siRNA Delivery

Jing Ma, Shashwati Kala, Susan Yung, Tak Mao Chan, Yu Cao, Yifan Jiang, Xiaoxuan Liu, Suzanne Giorgio, Ling Peng, Alice Wong

Molecular Therapy 26:70-83 (2018)10.1016/j.ymthe.2017.11.006

Precise tuning of single molecule conductance in an electrochemical environment

Ling Peng, F. Chen, Z.-W. Hong, J.-F. Zheng, Laure Fillaud, Y. Yuan, M.-L. Huang, Y. Shao, X.-S. Zhou, J.-Z. Chen, Emmanuel Maisonhaute

Nanoscale 10:7026-7032 (2018)10.1039/c8nr00625c

Carbon/Nitrogen Metabolic Balance: Lessons from Cyanobacteria

Cheng-Cai Zhang, Cong-Zhao Zhou, Robert Burnap, Ling Peng

Trends in Plant Science 23:1116-1130 (2018)10.1016/j.tplants.2018.09.008

Carbon/Nitrogen Metabolic Balance: Lessons from Cyanobacteria

Cheng-Cai Zhang, Cong-Zhao Zhou, Robert Burnap, Ling Peng

Trends in Plant Science 23:1116-1130 (2018)

Negative dendritic effect on enzymatic hydrolysis of dendrimer conjugates

Zhengwei Zhou, Mei Cong, Mengyao Li, Aura Tintaru, Jia Li, Jia Yao, Yi Xia, Ling Peng

Chemical Communications 54:5956-5959 (2018)10.1039/c8cc01221k