Jiaxuan Chen


Ingénierie Moléculaire et Matériaux Fonctionnels




+33(0)6 62 51 27 71


+33(0)4 91 41 89 16


TPR1 - 4 étage





A dual targeting dendrimer-mediated siRNA delivery system for effective gene silencing in cancer therapy

Y. Dong, T. Yu, L. Ding, E. Laurini, Y. Huang, M. Zhang, Y. Weng, S. Lin, P. Chen, D. Marson, Y. Jiang, S. Giorgio, S. Pricl, X. Liu, P. Rocchi, L. Peng

Journal of the American Chemical Society 140 16264-16274 (2018)

Mix and Match: co-assembly of amphiphilic dendrimers and phospholipids creates robust, modular and controllable interfaces

S. Hinman, C. Ruiz, J. Tang, M. Ma, Y. Cao, E. Laurini, P. Posocco, S. Pricl, S. Giorgio, L. Peng, Q. Cheng

ACS Applied Materials & Interfaces 9 1029-1035 (2017)

A fluorinated bola-amphiphilic dendrimer for on-demand delivery of siRNA via specific response to reactive oxygen species

X. Liu, Y. Wang, C. Chen, A. Tintaru, Y. Cao, J. Liu, F. Ziarelli, J. Tang, H. Guo, R. Rosas, S. Giorgio, L. Charles, P. Rocchi, L. Peng

Advanced Functional Materials 26 8594-8603 (2016)

N-Substituted Azacalixphyrins: Synthesis, Properties, and Self-Assembly

Z. Chen, R. Haddoub, J. Mahé, G. Marchand, D. Jacquemin, J. Andeme Edzang, G. Canard, D. Ferry, O. Grauby, A. Ranguis, O. Siri

Chemistry - A European Journal 22 17820-1783 (2016)

Transamination at the Crossroad of the One-Pot Synthesis of N-Substituted Quinonediimines and C-Substituted Benzobisimidazoles

J.A. Edzang, Z.R. Chen, H. Audi, G. Canard, O. Siri

Organic Letters 18 20 5340-5343 (2016)

Mastering dendrimer self-assembly for efficient siRNA delivery: from conceptual design to in vivo efficient gene silencing

C. Chen, P. Posocco, X. Liu, Q. Cheng, E. Laurini, J. Zhou, C. Liu, Y. Wang, J. Tang, V.D. Col, T. Yu, S. Giorgio, M. Fermeglia, F. Qu, Z. Liang, J.J. Rossi, M. Liu, P. Rocchi, S. Pricl, L. Peng

small 12 3667-3676 (2016)

1,3-Alternate Tetraamido-Azacalix[4]arenes as Selective Anion Receptors

G. Canard, J.A. Edzang, Z.R. Chen, M. Chesse, M. Elhabiri, M. Giorgi, O. Siri

Chemistry - A European Journal 22 16 5756-5766 (2016)

Understanding the tautomerism in azacalixphyrins

G. Marchand, P. Giraudeau, Z.R. Chen, M. Elhabiri, O. Siri, D. Jacquemin

Physical Chemistry Chemical Physics 18 14 9608-9615 (2016)

Downregulation of TLX induces TET3 expression and inhibits glioblastoma stem cell self-renewal and tumorigenesis

Q. Cui, S. Yang, P. Ye, E. Tian, G. Sun, J. Zhou, G. Sun, X. Liu, C. Chen, K. Murai, C. Zhao, K.T. Azizian, L. Yang, C. Warden, X. Wu, M. D'apuzzo, C. Brown, B. Badie, L. Peng, A. Riggs, J. Rossi, Y. Shi

Nature Communications 7 10637 (2016)

Measuring fast stochastic displacements of bio-membranes with dynamic optical displacement spectroscopy

C. Monzel, D. Schmidt, C. Kleusch, D. Kirchenbuechler, U. Seifert, A.-S. Smith, K. Sengupta, R. Merkel

Nature Communications 6 8162 (2015)

Nanodrug formed by coassembly of dual anticancer drugs to inhibit cancer cell drug resistance

Y. Zhao, F. Chen, Y. Pan, Z. Li, X. Xue, C.I. Okeke, Y. Wang, C. Li, L. Peng, P.C. Wang, X. Ma, X-J. Liang

ACS Applied Materials & Interfaces 7 19295-19305 (2015)

Chemical alkaline etching of silicon Mie particles

J. Proust, F. Bedu, S. Chenot, I. Soumahoro, I. Ozerov, B. Gallas, R. Abdeddaim, N. Bonod

Advanced Optical Materials 3 1280-1286 (2015)

Aging mechanisms in amorphous phase-change materials

J.Y. Raty, W. Zhang, J. Luckas, C. Chen, R. Mazzarello, C. Bichara, M. Wuttig

Nature Communications 6 7467 (2015)

Magnetic properties of self-organized Co dimer nanolines on Si/Ag(110)

L. Michez, K. Chen, F. Cheynis, F. Leroy, A. Ranguis, H. Jamgotchian, M. Hanbücken, L. Masson

Beilstein Journal of Nanotechnology 6 777-784 (2015)

Anticancer drug nanomicelles formed by self-assembling amphiphilic dendrimer to combat cancer drug resistance

T. Wei, C. Chen, J. Liu, C. Liu, P. Posocco, X. Liu, Q. Cheng, S. Huo, Z. Liang, M. Fermeglia, S. Pricl, X.-J. Liang, L. Peng

Proceedings of the National Academy of Sciences 112 10 2978–2983 (2015)

Promoting siRNA delivery via enhanced cellular uptake using an arginine-decorated amphiphilic dendrime

X. Liu, C. Liu, J. Zhou, C. Chen, F. Qu, J. Rossi, P. Rocchi, L. Peng

Nanoscale 7 3867-3875 (2015)

Structural characterization of new defective molecules in poly(amidoamide)dendrimers by combining mass spectrometry and nuclear magnetic resonance

A. Tintaru, R. Ungaro, X. Liu, C. Chen, L. Giordano, L. Peng, L. Charles

Analytica Chimica Acta 853 451-459 (2015)

Impacts of Ambient and Ablation Plasmas on Short- and Ultrashort-Pulse Laser Processing of Surfaces

N.M. Bulgakova, A.N. Panchenko, V.P. Zhukov, S.I. Kudryashov, A. Pereira, W. Marine, T. Mocek, A.V. Bulgakov

Micromachines 5 4 1344-1372 (2014)

Extendable nickel complex tapes that reach NIR absorptions

H. Audi, Z. Chen, A. Charaf-eddin, A. D'aleo, G. Canard, D. Jacquemin, O. Siri

Chemical Communications / Chem Commun (Cambridge) 50 96 15140-3 (2014)

Targeted delivery of Dicer substrate siRNA using a dual targeting peptide decorated dendrimer delivery system

X. Liu, C. Liu, C. Chen, M. Bentobji, F. Azario Cheillan, J. Tomassin Piana, F. Qu, P. Rocchi, L. Peng

Nanomedicine: Nanotechnology, Biology and Medicine 10 1627-1636 (2014)

Exceptional Stability of Azacalixphyrin and Its Dianion

G. Marchand, A.D. Laurent, Z.R. Chen, O. Siri, D. Jacquemin

Journal of Physical Chemistry A 118 38 8883-8888 (2014)

Adaptive amphiphilic dendrimer based nanoassemblies as robust and versatile siRNA delivery systems

X. Liu, J. Zhou, T. Yu, C. Chen, Q. Cheng, K. Sengupta, Y. Huang, H. Li, C. Liu, Y. Wang, P. Posocco, M. Wang, Q. Cui, S. Giorgio, M. Fermeglia, F. Qu, S. Pricl, Y. Shi, Z. Liang, P. Rocchi, J.J. Rossi, L. Peng

Angewandte Chemie International Edition 53 11822-11827 (2014)

Separation of rare gases and chiral molecules by selective binding in porous organic cages

L. Chen, P.S. Reiss, S.Y. Chong, D. Holden, K.E. Jelfs, T. Hasell, M.A. Little, A. Kewley, M.E. Briggs, A. Stephenson, K.M. Thomas, J.A. Armstrong, J. Bell, J. Busto, R. Noel, J. Liu, D.M. Strachan, P.K. Thallapally, A.I. Cooper

Nature Materials 13 954-960 (2014)

Fused Azacalix[4]arenes

R. Haddoub, M. Touil, Z. Chen, J-M. Raimundo, P. Marsal, M. Elhabiri, O. Siri

European Journal of Organic Chemistry 2014 4 745-752 (2014)

Conformational sensibility of PEO-PAMAM hybrid molecules to cations adducted upon electrospray ionization – A mass spectrometry, ion mobility and molecular modeling study

A. Tintaru, C. Chendo, Q. Wang, S. Viel, G. Quelever, L. Peng, P. Posocco, S. Pricl, L. Charles

Analytica Chimica Acta 808 163-174 (2014)

Azacalixarene : the hidden porphyrin cousin brought to light

Z. Chen, M. Giorgi, D. Jacquemin, M. Elhabiri, O. Siri

Angewandte Chemie/Angew Chem Int Ed 125 6370-6374 (2013)

A novel nucleoside analog inhibits microRNA-214 through targeting heat-shock factor 1 in human epithelial ovarian cancer

Y-F. Chen, Z. Dong, Y. Xia, J. Tang, L. Peng, S. Wang, D. Lai

Cancer Science 17 1683-1689 (2013)

Structural requirements of 2-oxoglutaric acid analogues to mimic its signaling function

X. Liu, Y. Wang, E. Laurini, P. Posocco, H. Chen, F. Ziarelli, A. Janicki, F. Qu, M. Fermeglia, S. Pricl, C-C. Zang, L. Peng

Organic Letters 15 4664-4665 (2013)

19F NMR: a valuable tool for studying biological events

H. Chen, S. Viel, F. Ziarelli, L. Peng

Chemical Society Reviews 42 7971 (2013)

Impact of siRNA overhangs for dendrimer-mediated siRNA delivery and gene silencing

P. Posocco, X. Liu, E. Laurini, D. Marson, C. Chen, C. Liu, M. Fermeglia, P. Rocchi, S. Pricl, L. Peng

Molecular Pharmaceutics 10 3262-3273 (2013)

Towards solution-processed ambipolar organic thin film transistors based on alpha,omega-hexyl-distyryl-bithiophene (DH-DS2T) and a fluorocarbon-substituted dicyanoperylene (PDIF-CN(2))

S. Nenon, T. Watanabe, H. Brisset, Z. Chen, J. Ackermann, F. Fages, S. Bernardini, M. Bendahan, K. Aguir, N. Yoshimoto, C. Videlot-ackermann

Journal of Optoelectronics and Advanced Materials 14 1-2 131-135 (2012)

Electrospray tandem mass spectrometry of poly(amino)ester dendrimers: dissociation rules and structural characterization of defective molecules

A. Tintaru, C. Chendo, V. Monnier, C. Bouillon, G. Quelever, L. Peng, L. Charles

International Journal of Mass Spectrometry 308 56-64 (2011)

A new approach to inherent chirality through the N/S ratio and/or the position in mixed heterocalix[4]arenes

J.-M. Raimundo, Z.R. Chen, O. Siri

Chemical Communications / Chem Commun (Cambridge) 47 37 10410-10412 (2011)

2-Difluoromethylene-4-methylenepentanoic Acid, A Paradoxical Probe Able To Mimic the Signaling Role of 2-Oxoglutaric Acid in Cyanobacteria

X.J. Liu, H. Chen, E. Laurini, Y. Wang, V. Dal Col, P. Posocco, F. Ziarelli, M. Fermeglia, C.C. Zhang, S. Pricl, L. Peng

Organic Letters 13 11 2924-2927 (2011)

Optical properties of dielectric thin films including quantum dots

F. Flory, Y.J. Chen, C.C. Lee, L. Escoubas, J.J. Simon, P. Torchio, J. Le Rouzo, S. Vedraine, H. Derbal-habak, I. Shupyk, Y. Didane, J. Ackermann

Applied Optics 50 9 C129-C134 (2011)

Internally referenced analysis of charge-transfer reactions in a new ferrocenyl bithiophenic conducting polymer through cyclic voltammetry

C. Peng, X. Zhou, G.Z. Chen, F. Moggia, F. Fages, H. Brisset, J. Roncali

Chemical Communications / Chem Commun (Cambridge) 48 6606-6608 (2008)

2D aggregation and selective desorption of nanoparticle probes: A new method to probe DNA mismatches and damages

A. Charrier, N. Candoni, N. Liachenko, F. Thibaudau

Biosensors and Bioelectronics 22 9-10 1881-1886 (2007)

In-situ and real-time investigation of columnar-to-equiaxed transition in metallic alloy

H. Nguyen-thi, G. Reinhart, N. Mangelinck-noel, H. Jung, B. Billia, T. Schenk, J. Gastaldi, J. Hartwig, J. Baruchel

Metallurgical and Materials Transactions A 38 7 1458-1464 (2007)

In situ study of quasicrystal growth by synchrotron X-ray imaging

J. Gastaldi, G. Reinhart, H. Nguyen-thi, N. Mangelinck-noel, B. Billia, T. Schenk, J. Hartwig, B. Grushko, H. Klein, A. Buffet, J. Baruchel, H. Jung, P. Pino, B. Przepiarzynski

Philosophical Magazine 87 18-21 3079-3087 (2007)

The Samson phase, beta-Mg2Al3, revisited

M. Feuerbacher, C. Thomas, J. Makongo, S. Hoffmann, W. Carrillo-cabrera, R. Cardoso, Y. Grin, G. Kreiner, J.M. Joubert, T. Schenk, J. Gastaldi, H. Nguyen-thi, N. Mangelinck-noel, B. Billia, P. Donnadieu, A. Czyrska-filemonowicz, A. Zielinska-lipiec, B. Du

Zeitschrift für Kristallographie 222 6 259-288 (2007)

Real-time and in situ solidification of Al-based alloys investigated by synchrotron radiation : a unique experimental set-up combining radiography and topography techniques

A. Buffet, G. Reinhart, T. Schenk, H. Nguyen-thi, J. Gastaldi, N. Mangelinck-noel, H. Jung, J. Hartwig, J. Baruchel, B. Billia

Current Opinion in Colloid and Interface Science 204 8 2721-2727 (2007)

Influence of intermolecular orientation on the photoinduced charge transfer kinetics in self-assembled aggregates of donor-acceptor arrays

E.H.A. Beckers, S.C.J. Meskers, APHJ SCHENNING. , Z.J. Chen, F. Wurthner, P. Marsal, D. Beljonne, J. Cornil, RAJ. Janssen

Journal of the American Chemical Society 128 2 649-657 (2006)

Ethanol vapor detection in saline solution using piezoresistive microcantilevers

C. Parks-cheney, A. Wig, D.L. Hedden, A. Gehl, A.L. Lereu, R.H. Farahi, S.R. Hunter, T.L. Ferrell

Review of Scientific Instruments 77 095101 (2006)

Investigation on the Signaling Role of 2-Oxoglutaric Acid, a Krebs Cycle Intermediate

H. Chen, S. Laurent, S.B. Du Fabio Ziarelli, H. Chen, Y. Cheng, C-C. Zhang, L. Peng

Chemical Biology 13 849-856 (2006)

In situ and real-time probing of quasicrystal solidification dynamics by synchrotron imaging

H.N. Thi, J. Gastaldi, T. Schenk, G. Reinhart, N. Mangelinck-noel, V. Cristiglio, B. Billia, B. Grushko, J. Hartwig, H. Klein, J. Baruchel

Physical Review E - Statistical, Nonlinear, and Soft Matter Physics 74 3 031605 (2006)

In situ and real time investigation of directional solidification of Al-Ni alloys by synchrotron imaging

G. Reinhart, H. Nguyen-thi, J. Gastaldi, B. Billia, N. Mangelinck-noel, T. Schenk, J. Hartwig, J. Baruchel

Solidification and Gravity IV - Materials Science Forum 508 75-80 (2006)

"In situ" observation of pore evolution during melting and solidification of Al-Pd-Mn quasicrystals by synchrotron X-ray radiography

J. Gastaldi, T. Schenk, G. Reinhart, Y. Klein, J. Hartwig, N. Mangelinck-noel, B. Grushko, T. H. Nguyen, P. Pino, B. Billia, J. Baruchel

Philosophical Magazine 86 3-5 335 (2006)

In situ observation of pore evolution during melting and solidification of Al-Pd-Mn quasicrystals by synchrotron X-ray radiography

J. Gastaldi, T. Schenk, G. Reinhart, H. Klein, J. Hartwig, N. Mangelinck-noel, B. Grushko, H.N. Thi, P. Pino, B. Billia, J. Baruchel

Philosophical Magazine 86 3-5 335-340 (2006)

Synchotron X-ray diffractometry and imaging on strains and defects in icosahedral quasicrystal grains

J. Gastaldi, T. Schenk, L. Mancini, H. Klein, J. Härtwig, S. Agliozzo, J. Baruchel, M. De Boissieu

Philosophical Magazine 86 36 5897-5907 (2006)

Investigation of columnar equiaxed transition and equiaxed growth of aluminium based alloys by X-ray radiography

G. Reinhart, N. Mangelinck-noel, H. Nguyen-thi, T. Schenk, J. Gastaldi, B. Billia, P. Pino, J. Hartwig, J. Baruchel

Materials Science and Engineering A 413-414 384-388 (2005)