Ling Peng

Localisation

TPR1 - 4 étage

Grade

DR1

Function

chercheur

Room

G4.17

peng.jpg

Activity

dendrimers, drug delivery, nanobiotechnology, nanomedicine

Themes

1.     Functional biomaterials for drug delivery based on dendrimer nanotechnology

2.     Molecular probes and chemical biology

3.     Drug discovery based on triazole nucleoside chemistry

Recherche

Functional biomaterials based on dendrimer nanotechnology: In order to treat various life-threatening diseases such as cancer, infection and neurodegenerative dementia, it is essential to develop efficient systems which enable precise diagnosis and effective treatment by delivering the right pharmaceutics at the right site with the right dose and timing. Dendrimers are the ideal precision materials for drug delivery by virtue of their uniquely well-defined and precisely controlled structure with multivalent cooperativity confined within a nanosized volume. We are developing functional biocompatible dendrimer materials for bioimaging-based diagnosis, cancer treatment and gene therapy based on self-assembling supramolecular chemistry.

Molecular probes and chemical biology: Molecular probes are useful tools to study and understand biological events. We have designed and synthesized various molecular probes of phospholipids and of 2-oxoglutarate, an important intermediate of the Kreb’s cycle, with a view to studying bio-membranes and the signaling roles and pathways of Kreb’s cycle intermediates in nitrogen fixation and cancer development.

Drug discovery based on triazole nucleoside chemistry: Nucleoside mimics are of great importance in the search for antiviral, anticancer and antibacterial drug candidates. One noteworthy example is ribavirin, the first synthetic triazole nucleoside showing antiviral activity against a broad spectrum of viruses. We have developed novel triazole nucleoside derivatives using modern green chemistry. Some of the lead compounds have shown excellent potency against drug-resistant cancers with novel modes of action such as targeting the heat shock response pathway, inducing autophagy and eliciting an immunomodulation effect etc.

Parcours

Dr. Ling Peng is a research director at the French National Scientific Research Center (CNRS) in France. She carried her undergraduate study in polymer chemistry with Prof. Chen Rongshi at Nanjing University in China, her PhD program in organic chemistry with Prof. Albert Eschenmoser at Swiss Federal Institute of Technology in Zurich, Switzerland, and her postdoctoral research in pharmacy with Prof. Maurice Goeldner at Louis Pasteur University of Strasbourg in France. She was recruited as a research scientist in CNRS in 1997, promoted as a CNRS research director in 2008, then the 1st class Research Director in 2015 and the exceptional class Research Director in 2023.

Dr. Ling PENG has been working actively at the interface of chemistry and biology, and in particular, developing functional dendrimers for biomedical applications, molecular probes for exploring biological events and nucleoside analogues for drug discovery. She has established bio-inspired structurally flexible dendrimers for nucleic acid delivery. Recently, she has inaugurated the concept of self-assembling supramolecular dendrimers, and applied this concept to deliver various anticancer drugs, nucleic acid therapeutics and imaging agents for cancer treatment and imaging. Her research team has been labelled by La Ligue contre Le Cancer in France since 2016.

Dr. Ling PENG is the Distinguished Member of the French Chemical Society since 2019. She was awarded with the Prize of Dr & Mme Henri Labbé of the French Academy of Sciences in 2017, the Grand Prize of the French Chemical Society SUD PACA and the Prize of André Collet of Supramolecualr Chemistry of French Chemical Society in 2024.

 

Selected Publications:

  

1.   Zhenbin Lyu, Brigino Ralahy, Teodora-Adriana Perles-Barbacaru, Ling Ding, Yifan Jiang, Baoping Lian, Tom Roussel, Xi Liu, Christina Galanakou, Erik Laurini, Aura Tintaru, Suzanne Giorgio, Sabrina Pricl, Xiaoxuan Liu, Juan Iovanna, Monique Bernard, Angèle Viola, Ling Peng, “Self-assembling dendrimer nanosystems for specific fluorine magnetic resonance imaging and effective theranostic treatment of tumors”, Proc. Natl. Acad. Sci. U.S.A. 2024121, e2322403121.

 

2.   Nian Zhang, Dinesh Dhumal, Shanny Hsuan Kuo, Shi Qian Lew, Pankaj D Patil, Raleb Taher, Sanika Vaidya, Christina Galanakou, Abdechakour Elkihel, Myung Whan Oh, Sook Yin Chong, Domenico Marson, Jun Zheng, Oleg Rouvinski, Williams O. Abolarin, Sabrina Pricl, Gee W. Lau, Leo Tsz On Lee, Ling Peng, "Targeting the phosphatidylglycerol phospholipid: an amphiphilic dendrimer as a promising antibacterial candidate", Sci. Adv. 2024, 10, eadn8117.

 

3.    Jiaxuan Chen, Dandan Zhu, Baoping Lian, Kangjie Shi, Peng Chen, Ying Li, Wenyi Lin, Ling Ding, Qiulin Long, Yang Wang, Erik Laurini, Wenjun Lan, Yun Li, Aura Tintaru, Caoyun Ju, Can Zhang, Sabrina Pricl, Juan Iovanna, Xiaoxuan Liu, Ling Peng, “Cargo-selective and adaptive delivery of nucleic acids by bola-amphiphilic dendrimers”, Proc. Natl. Acad. Sci. U.S.A. 2023120, e2220787120. DOI: 10.1073/pnas.2220787120.

 

4.     Yifan Jiang, Zhenbin Lyu, Brigino Ralahy, Juan Liu, Tom Roussel, Ling Ding, Jingjie Tang, Artemis Kosta, Suzanne Giorgio, Richard Tomasini, Xing-Jie Liang, Nelson Dusetti, Juan Iovanna, Ling Peng, “Dendrimer nanosystems for adaptive tumour-assisted drug delivery via extracellular vesicle hijacking”, Proc. Natl. Acad. Sci. U.S.A. 2023120, e2215308120. DOI: 10.1073/pnas.2215308120. 

 

5. Jiaxuan Chen, Dandan Zhu, Xiaoxuan Liu, Ling Peng, “Amphiphilic dendrimer vectors for RNA delivery: state-of-the-art and future perspective”, Acc. Mater. Res. 20223, 484-497. DOI:10.1021/accountsmr.1c00272

 

6.   Jiaxuan Chen, Aleksandra Ellert-Miklaszewska, Stefano Garofalo, Arindam K Dey, Jingjie Tang, Yifan Jiang, Flora Clément, Patrice N Marche, Xiaoxuan Liu, Bozena Kaminska, Angela Santoni, Cristina Limatola, John Rossi, Jiehua Zhou, Ling Peng, “Synthesis and use of an amphiphilic dendrimer for siRNA delivery into primary immune cells”, Nat. Protoc. 202116, 327–351. DOI: 10.1038/s41596-020-00418-9

 

7.   Zhenbin Lyu, Ling Ding, Aura Tintaru, Ling Peng, “Self-assembling supramolecular dendrimers for biomedical applications: lessons learned from poly(amido)amine dendrimers”, Acc. Chem. Res202053, 2936-2946. DOI: 10.1021/acs.accounts.0c00589

 

8. Philippe Garrigue, Jingjie Tang, Ling Ding, Ahlem Bouhlel, Aura Tintaru, Erik Laurini, Yuanyu Huang, Zhenbin Lyu, Mengjie Zhang, Samantha Fernandez, Laure Balasse, Wenjun Lan, Eric Mas, Domenico Marson, Yuhua Weng, Xiaoxuan Liu, Suzanne Giorgio, Juan Iovanna, Sabrina Pricl, Benjamin Guillet, Ling Peng, “Self-assembling supramolecular dendrimer nanosystem for PET imaging of tumors”, Proc. Natl. Acad. Sci. U.S.A. 2018115, 11454-11459. DOI: 10.1073/pnas.1812938115

 

9.   Yiwen Dong, Tianzhu Yu, Ling Ding, Erik Laurini, Yuanyu Huang, Mengjie Zhang, Yuhua Weng, Shuting Lin, Peng Chen, Domenico Marson, Yifan Jiang, Suzanne Giorgio, Sabrina Pricl, Xiaoxuan Liu, Palma Rocchi, Ling Peng, “A dual targeting dendrimer-mediated siRNA delivery system for effective gene silencing in cancer therapy”, J. Am. Chem. Soc. 2018140, 16264-16274. DOI: 10.1021/jacs.8b10021

 

10. Xiaoxuan Liu, Yang Wang, Chao Chen, Aura Tintaru, Yu Cao, Juan Liu, Fabio Ziarelli, Jingjie Tang, Hongbo Guo, Roseline Rosas, Suzanne Giorgio, Laurence Charles, Palma Rocchi, Ling Peng, “A fluorinated bola-amphiphilic dendrimer for on-demand delivery of siRNA, via specific response to reactive oxygen species”, Adv. Funct. Mater. 201626, 8594-8603. DOI: 10.1002/adfm.201604192

 

11. Tuo Wei, Juan Liu, Chao Chen, Cheng Liu, Paola Posocco, Xiaoxuan Liu, Qiang Cheng, Shuaidong Huo, Zicai Liang, Maurizio Fermeglia, Sabrina Pricl, Xing-Jie Liang, Palma Rocchi, Ling Peng, “Anticancer drug nanomicelles formed by self-assembling amphiphilic dendrimer to combat cancer drug resistance”, Proc. Natl. Acad. Sci. U.S.A. 2015112, 29782983. DOI: 10.1073/pnas.1418494112.

 

12. Xiaoxuan Liu, Jiehua Zhou, Tianzhu Yu, Chao Chen, Qiang Cheng, Yuanyu Huang, Kheya Sengupta, Haitang Li, Cheng Liu, Yang Wang, Menghua Wang, Suzanne Giorgio, Fanqi Qu, Zicai Liang, Palma Rocchi, John J Rossi, Ling Peng, “Adaptive amphiphilic dendrimer based nanoassemblies as robust and versatile siRNA delivery systems”, Angew. Chem. Int. Ed. 201453, 11822–11827. DOI: 10.1002/anie.201406764

 

Publications

2024

Amphiphilic Dendrimer as Potent Antibacterial against Drug-Resistant Bacteria in Mouse Models of Human Infectious Diseases

Noah King, Dinesh Dhumal, Shi Qian Lew, Shanny Hsuan Kuo, Christina Galanakou, Myung Whan Oh, Sook Yin Chong, Nian Zhang, Leo Tsz On Lee, Zvi Hayouka, Ling Peng, Gee W Lau

ACS Infectious Diseases 10:453-466 (2024)10.1021/acsinfecdis.3c00425

Development of an efficient NUPR1 inhibitor with anticancer activity

Xi Liu, Ana Jimenez-Alesanco, Zexian Li, Bruno Rizzuti, José L Neira, Matías Estaras, Ling Peng, Eduardo Chuluyan, Juan Garona, Florencia Gottardo, Adrián Velazquez-Campoy, Yi Xia, Olga Abian, Patricia Santofimia-Castaño, Juan Iovanna

Scientific Reports 14:29515 (2024)10.1038/s41598-024-79340-z

Self-assembling dendrimer nanosystems for specific fluorine magnetic resonance imaging and effective theranostic treatment of tumors

Zhenbin Lyu, Brigino Ralahy, Teodora-Adriana Perles-Barbacaru, Ling Ding, Yifan Jiang, Baoping Lian, Tom Roussel, Xi Liu, Christina Galanakou, Erik Laurini, Aura Tintaru, Suzanne Giorgio, Sabrina Pricl, Xiaoxuan Liu, Monique Bernard, Juan Iovanna, Angèle Viola, Ling Peng

Proceedings of the National Academy of Sciences of the United States of America 121:e2322403121 (2024)10.1073/pnas.2322403121

Insight into the Internal Structure of High-Performance Multicore Magnetic Nanoparticles Used in Cancer Thermotherapy

Tom Roussel, Daniel Ferry, Artemis Kosta, Dalila Miele, Giuseppina Sandri, Felista Tansi-Lemnyui, Frank Steiniger, Paul Southern, Quentin Pankhurst, Ling Peng, Suzanne Giorgio

ACS Materials Au (2024)

The synergistic neurovascular electro-healing of infected diabetic wounds by a multifaceted absorbable ion-conductive adhesive patch

Wenlong Wei, Jiayi Zheng, Ziru Liu, Ziqiu Li, Xiangyu Chen, Wenyue Yang, Pier-Luc Tremblay, Ling Peng, Tian Zhang

Chemical Engineering Journal 500:156387 (2024)10.1016/j.cej.2024.156387

Targeting the phosphatidylglycerol lipid: An amphiphilic dendrimer as a promising antibacterial candidate

Nian Zhang, Dinesh Dhumal, Shanny Hsuan Kuo, Shi Qian Lew, Pankaj Patil, Raleb Taher, Sanika Vaidya, Christina Galanakou, Abdechakour Elkihel, Myung Whan Oh, Sook Yin Chong, Domenico Marson, Jun Zheng, Oleg Rouvinski, Williams Abolarin, Sabrina Pricl, Gee Lau, Leo Tsz On Lee, Ling Peng

Science Advances 10:eadn8117 (2024)10.1126/sciadv.adn8117

Capture and flocculation of toxic cyanobacteria by amphiphilic peptide dendrimers for mitigating harmful blooms

Heng Zheng, Pier-Luc Tremblay, Wang Chen, Qi Wang, Danni Hu, Yuanzheng Huang, Xiaoxuan Liu, Cheng-Cai Zhang, Ling Peng, Tian Zhang

Chemical Engineering Journal (2024)10.1016/j.cej.2024.151382

2023

Progress and Harmonization of Gene Editing to Treat Human Diseases (Proceeding of COST Action CA21113 GenE-HumDi)

Alessia Cavazza, Ayal Hendel, Rasmus O Bak, Paula Rio, Marc Güell, Duško Lainšček, Virginia Arechavala-Gomeza, Ling Peng, Fatma Zehra Hapil, Joshua Harvey, Francisco G Ortega, Coral Gonzalez-Martinez, Carsten W Lederer, Kasper Mikkelsen, Giedrius Gasiunas, Nechama Kalter, Manuel a F V Gonçalves, Julie Petersen, Alejandro Garanto, Lluis Montoliu, Marcello Maresca, Stefan E Seemann, Jan Gorodkin, Loubna Mazini, Rosario Sanchez, Juan R Rodriguez-Madoz, Noelia Maldonado-Pérez, Torella Laura, Michael Schmueck-Henneresse, Cristina Maccalli, Julian Grünewald, Gloria Carmona, Neli Kachamakova-Trojanowska, Annarita Miccio, Francisco Martin, Giandomenico Turchiano, Toni Cathomen, Yonglun Luo, Shengdar Q Tsai, Karim Benabdellah

Molecular Therapy - Nucleic Acids (2023)10.1016/j.omtn.2023.102066

Cargo-selective and adaptive delivery of nucleic acid therapeutics by bola-amphiphilic dendrimers

Jiaxuan Chen, Dandan Zhu, Baoping Lian, Kangjie Shi, Peng Chen, Ying Li, Wenyi Lin, Ling Ding, Qiulin Long, Yang Wang, Erik Laurini, Wenjun Lan, Yun Li, Aura Tintaru, Caoyun Ju, Can Zhang, Sabrina Pricl, Juan Iovanna, Xiaoxuan Liu, Ling Peng

Proceedings of the National Academy of Sciences of the United States of America 120:e2220787120 (2023)10.1073/pnas.2220787120

Modular Self‐Assembling Dendrimer Nanosystems for Magnetic Resonance And Multimodality Imaging of Tumors

Ling Ding, Zhenbin Lyu, Teodora‐adriana Perles-Barbacaru, Adela Ya‐ting Huang, Baoping Lian, Yifan Jiang, Tom Roussel, Christina Galanakou, Suzanne Giorgio, Chai‐lin Kao, Xiaoxuan Liu, Juan Iovanna, Monique Bernard, Angèle Viola, Ling Peng

Advanced Materials (2023)10.1002/adma.202308262

Amphiphilic dendrimers against antibiotic resistance: light at the end of the tunnel?

Christina Galanakou, Dinesh Dhumal, Ling Peng

Biomaterials Science (2023)10.1039/D2BM01878K

Dendrimer nanosystems for adaptive tumor-assisted drug delivery via extracellular vesicle hijacking

Yifan Jiang, Zhenbin Lyu, Brigino Ralahy, Juan Liu, Tom Roussel, Ling Ding, Jingjie Tang, Artemis Kosta, Suzanne Giorgio, Richard Tomasini, Xing-Jie Liang, Nelson Dusetti, Juan Iovanna, Ling Peng

Proceedings of the National Academy of Sciences of the United States of America 120 (2023)10.1073/pnas.2215308120

2022

Amphiphilic Dendrimer Vectors for RNA Delivery: State-of-the-Art and Future Perspective

Jiaxuan Chen, Dandan Zhu, Xiaoxuan Liu, Ling Peng

Accounts of Materials Research (2022)10.1021/accountsmr.1c00272

Dynamic self-assembling supramolecular dendrimer nanosystems as potent antibacterial candidates against drug-resistant bacteria and biofilms

Dinesh Dhumal, Bar Maron, Einav Malach, Zhenbin Lyu, Ling Ding, Domenico Marson, Erik Laurini, Aura Tintaru, Brigino Ralahy, Suzanne Giorgio, Sabrina Pricl, Zvi Hayouka, Ling Peng

Nanoscale (2022)10.1039/d2nr02305a

Thermostable ionizable lipid-like nanoparticle (iLAND) for RNAi treatment of hyperlipidemia

Bo Hu, Bo Li, Kun Li, Yuanyuan Liu, Chunhui Li, Lulu Zheng, Mengjie Zhang, Tongren Yang, Shuai Guo, Xiyu Dong, Tian Zhang, Qing Liu, Abid Hussain, Yuhua Weng, Ling Peng, Yongxiang Zhao, Xing-Jie Liang, Yuanyu Huang

Science Advances 8 (2022)10.1126/sciadv.abm1418

Solid-phase dendrimer synthesis: a promising approach to transform dendrimer construction

Ya-Ting Huang, C.-L Kao, A Selvaraj, Ling Peng

Materials Today Chemistry (2022)10.1016/j.mtchem.2022.101285

A biodegradable amphiphilic poly(aminoester) dendrimer for safe and effective siRNA delivery

Chi Ma, Dandan Zhu, Wenyi Lin, Ying Li, Yuanzheng Huang, Huiling Zhu, Mengyun Ye, Yang Wang, Ling Peng, Xiaoxuan Liu

Chemical Communications (2022)10.1039/D1CC06655B

NUPR1 protects against hyperPARylation-dependent cell death

Patricia Santofimia-Castano, Can Huang, Xi Liu, Yi Xia, Stephane Audebert, Luc Camoin, Ling Peng, Gwen Lomberk, Raul Urrutia, Philippe Soubeyran, Jose Luis Neira, Juan Iovanna

Communications Biology 5 (2022)10.1038/s42003-022-03705-1

Small Activating RNA Modulation of the G Protein‐Coupled Receptor for Cancer Treatment

Yunfang Xiong, Ran Ke, Qingyu Zhang, Wenjun Lan, Wanjun Yuan, Karol Nga Ieng Chan, Tom Roussel, Yifan Jiang, Jing Wu, Shuai Liu, Alice Sze Tsai Wong, Joong Sup Shim, Xuanjun Zhang, Ruiyu Xie, Nelson Dusetti, Juan Iovanna, Nagy Habib, Ling Peng, Leo Tsz On Lee

Advanced Science 2200562 (2022)10.1002/advs.202200562

Bola‐Amphiphilic Glycodendrimers: New Carbohydrate Mimicking Scaffolds to Target Carbohydrate‐Binding Proteins

Wenzheng Zhang, Dinesh Dhumal, Xiaolei Zhu, Brigino Ralahy, Aleksandra Ellert-Miklaszewska, Jing Wu, Erik Laurini, Yi-Wen W Yao, Chai-Lin L Kao, Juan L Iovanna, Sabrina Pricl, Bozena Kaminska, Yi Xia, Ling Peng

Chemistry - A European Journal (2022)10.1002/chem.202201400

2021

Synthesis and use of an amphiphilic dendrimer for siRNA delivery into primary immune cells

Jiaxuan Chen, Aleksandra Ellert-Miklaszewska, Stefano Garofalo, Arindam K Dey, Jingjie Tang, Yifan Jiang, Flora Clément, Patrice N. Marche, Xiaoxuan Liu, Bozena Kaminska, Angela Santoni, Cristina Limatola, John Rossi, Jiehua Zhou, Ling Peng

Nature Protocols (2021)10.1038/s41596-020-00418-9

A self-assembling prodrug nanosystem to enhance metabolic stability and anticancer activity of gemcitabine

Mei Cong, Guangling Xu, Shaoyou Yang, Jing Zhang, Wenzheng Zhang, Dinesh Dhumal, Erik Laurini, Kaiyue Zhang, Yi Xia, Sabrina Pricl, Ling Peng, Weidong Zhao

Chinese Chemical Letters (2021)10.1016/j.cclet.2021.11.083

An ionizable supramolecular dendrimer nanosystem for effective siRNA delivery with a favorable safety profile

Dinesh Dhumal, Wenjun Lan, Ling Ding, Yifan Jiang, Zhenbin Lyu, Erik Laurini, Domenico Marson, Aura Tintaru, Nelson Dusetti, Suzanne Giorgio, Juan Lucio Iovanna, Sabrina Pricl, Ling Peng

Nano Research (2021)10.1007/s12274-020-3216-8

NUPR1 inhibitor ZZW-115 induces ferroptosis in a mitochondria-dependent manner

Can Huang, Patricia Santofimia-Castaño, Xi Liu, Yi Xia, Ling Peng, Célia Gotorbe, Jose Luis Neira, Daolin Tang, Jacques Pouyssegur, Juan Iovanna

Cell Death Discovery 7:269 (2021)10.1038/s41420-021-00662-2

Dendrimeric Nanosystem Consistently Circumvents Heterogeneous Drug Response and Resistance in Pancreatic Cancer

Juan Liu, Chao Chen, Tuo Wei, Odile Gayet, Céline Loncle, Laurence Borge, Nelson Dusetti, Xiaowei Ma, Domenico Marson, Erik Laurini, Sabrina Pricl, Zhongwei Gu, Juan Iovanna, Ling Peng, Xing‐jie Liang

Energy Exploration and Exploitation 1:21-34 (2021)10.1002/EXP.20210003

Design of Inhibitors of the Intrinsically Disordered Protein NUPR1: Balance between Drug Affinity and Target Function

Bruno Rizzuti, Wenjun Lan, Patricia Santofimia-Castaño, Zhengwei Zhou, Adrián Velázquez-Campoy, Olga Abián, Ling Peng, José Neira, Yi Xia, Juan Iovanna

Biomolecules 11:1453 (2021)10.3390/biom11101453

2020

Targeting NUPR1 with the small compound ZZW-115 is an efficient strategy to treat hepatocellular carcinoma

Wenjun Lan, Patricia Santofimia-Castaño, Yi Xia, Zhengwei Zhou, Can Huang, Nicolas Fraunhoffer, Dolores Barea, Melchiore Cervello, Lydia Giannitrapani, Giuseppe Montalto, Ling Peng, Juan Iovanna

Cancer Letters 486:8-17 (2020)10.1016/j.canlet.2020.04.024

Novel Aryltriazole Acyclic C-Azanucleosides as Anticancer Candidates

Yanhua Zhang, Yun Lin, Qianqian Hou, Xi Liu, Sabrina Pricl, Ling Peng, Yi Xia

Organic & Biomolecular Chemistry (2020)10.1039/d0ob02164d