Department IMMF

Molecular Engineering and Functional Materials

Leader: Olivier Margeat


The research activities of the "Molecular Engineering and Functional Materials" department (IMMF) stand at the interface of chemistry-physics-biology and focus on the synthesis, the physico-chemical characterization and the property studies of organic, inorganic and/or hybrid molecular structures.

These activities are divided around three research themes:




  • Vectorization


  • Bioimaging / Diagnostic


  • Therapy


Singular conjugated


  • Engineering of chromophores and fluorophores


  • Molecular switches


  • Supramolecular chemistry


Surfaces, thin films
& devices


  • Assemblies on surface


  • Functional coatings


  • Optoelectronic devices




Exploring Charge Transport in High‐Temperature Polymorphism of ITIC Derivatives in Simple Processed Unipolar Bottom Contact Organic Field‐Effect Transistor

Yatzil Alejandra Avalos Quiroz, Tomoyuki Koganezawa, Pavlo Perkhun, Elena Barulina, Carmen Ruiz Herrero, Jörg Ackermann, Noriyuki Yoshimoto, Christine Videlot-Ackermann

Advanced Electronic Materials 2100743 (2022)10.1002/aelm.202100743

Improved ultraviolet stability of fullerene-based organic solar cells through light-induced enlargement and crystallization of fullerene domains

Elena Barulina, Anass Khodr, Sadok Ben Dkhil, Pavlo Perkhun, Yatzil Alejandra Avalos Quiroz, Tomoyuki Koganezawa, Noriyuki Yoshimoto, Wolfgang Köntges, Rasmus Schröder, Martin Pfammöller, Olivier Margeat, Jörg Ackermann, Christine Videlot-Ackermann

Thin Solid Films 757:139394 (2022)10.1016/j.tsf.2022.139394

Amphiphilic Dendrimer Vectors for RNA Delivery: State-of-the-Art and Future Perspective

Jiaxuan Chen, Dandan Zhu, Xiaoxuan Liu, Ling Peng

Accounts of Materials Research (2022)10.1021/accountsmr.1c00272

Dynamic self-assembling supramolecular dendrimer nanosystems as potent antibacterial candidates against drug-resistant bacteria and biofilms

Dinesh Dhumal, Bar Maron, Einav Malach, Zhenbin Lyu, Ling Ding, Domenico Marson, Erik Laurini, Aura Tintaru, Brigino Ralahy, Suzanne Giorgio, Sabrina Pricl, Zvi Hayouka, Ling Peng

Nanoscale (2022)10.1039/d2nr02305a

Fully Zwitterionic Diaminobenzoquinonediimines Promoted by Cyanoaromatic N-substituents

Tereza Horáčková, Manon H.E. Bousquet, Adrien Morice, Ugo Triballier, Gabriel Canard, Pavel Lhoták, Denis Jacquemin, Simon Pascal, Olivier Siri

Dyes and Pigments (2022)10.1016/j.dyepig.2022.110681

Thermostable ionizable lipid-like nanoparticle (iLAND) for RNAi treatment of hyperlipidemia

Bo Hu, Bo Li, Kun Li, Yuanyuan Liu, Chunhui Li, Lulu Zheng, Mengjie Zhang, Tongren Yang, Shuai Guo, Xiyu Dong, Tian Zhang, Qing Liu, Abid Hussain, Yuhua Weng, Ling Peng, Yongxiang Zhao, Xing-Jie Liang, Yuanyu Huang

Science Advances 8 (2022)10.1126/sciadv.abm1418

Solid-phase dendrimer synthesis: a promising approach to transform dendrimer construction

Ya-Ting Huang, C.-L Kao, A Selvaraj, Ling Peng

Materials Today Chemistry (2022)10.1016/j.mtchem.2022.101285

A biodegradable amphiphilic poly(aminoester) dendrimer for safe and effective siRNA delivery

Chi Ma, Dandan Zhu, Wenyi Lin, Ying Li, Yuanzheng Huang, Huiling Zhu, Mengyun Ye, Yang Wang, Ling Peng, Xiaoxuan Liu

Chemical Communications (2022)10.1039/D1CC06655B

Affinity driven ion exchange EG-OFET sensor for high selectivity and low limit of detection of Cesium in seawater

Tin Phan Nguy, Volkan Kilinc, Ryoma Hayakawa, Catherine Henry-De-Villeneuve, Jean-Manuel Raimundo, Yutaka Wakayama, Anne Charrier

Sensors and Actuators B: Chemical 351:130956 (2022)10.1016/j.snb.2021.130956

Affinity driven ion exchange EG-OFET sensor for high selectivity and low limit of detection of cesium in seawater

Tin Phan Nguy, Volkan Kilinc, Ryoma Hayakawa, Catherine Henry-De-Villeneuve, Jean-Manuel Raimundo, Yutaka Wakayama, Anne Charrier

Sensors and Actuators B: Chemical 351:130956 (2022)10.1016/j.snb.2021.130956

NIR-to-NIR two-photon bio-imaging using very bright tailored amino-heptamethines dyes

Simon Pascal, San-Hui Chi, Alexei Grichine, Veronique Martel-Frachet, Joseph Perry, Olivier Maury, Chantal Andraud

Dyes and Pigments 110369 (2022)10.1016/j.dyepig.2022.110369

Highly emissive layers based on organic/inorganic nanohybrids using Aggregation Induced Emission effect

Jonathan Phelipot, Nicolas Ledos, Thomas Dombray, Matthew P Duffy, Mathieu Denis, Ting Wang, Yahia Didane, Meriem Gaceur, Qinye Bao, Xianjie Liu, Mats Fahlman, Pietro Delugas, Alessandro Mattoni, Denis Tondelier, Bernard Geffroy, Pierre-Antoine Bouit, Olivier Margeat, Jörg Ackermann, Muriel Hissler

Advanced Materials Technologies 7:2100876 (2022)10.1002/admt.202100876

Nanohybrids as a tool to control the dispersion of organic emitters in solution-processed electroluminescent layers

Jonathan Phelipot, Payal Manzhi, Nicolas Ledos, Denis Tondelier, Bernard Geffroy, Pierre- Antoine Bouit, Jörg Ackermann, Muriel Hissler, Olivier Margeat

New Journal of Chemistry (2022)10.1039/D2NJ05016A

Synthesis and Electron Accepting Properties of Two Di(benz[f]indenone)-Fused Tetraazaanthracene Isomers

Bruno Salgues, Rudraditya Sarkar, Muhammad Fajri, Yatzil Avalos-Quiroz, Anne-Doriane Manick, Michel Giorgi, Nicolas Vanthuyne, Yannick Carissan, Christine Videlot-Ackermann, Jörg Ackermann, Gabriel Canard, Jean-Luc Parrain, Boris Le Guennic, Denis Jacquemin, Muriel Amatore, Laurent Commeiras, Elena Zaborova, Fréderic Fagès

Journal of Organic Chemistry 87:3276-3285 (2022)10.1021/acs.joc.1c02942

Conjugated donor–acceptor substituted systems involving the 1,3-indandione-derived electron accepting moieties

Mark Sigalov, Royi Mazor, Arkady Ellern, Nina Larina, Vladimir Lokshin, Vladimir Khodorkovsky

RSC Advances 12:27766-27774 (2022)10.1039/d2ra05335g

Covalent organic framework based on azacalix[4]arene for the efficient capture of dialysis waste products

Tina Skorjanc, Dinesh Shetty, Felipe Gándara, Simon Pascal, Nawavi Naleem, Salma Abubakar, Liaqat Ali, Abdul Khayum Mohammed, Jesus Raya, Serdal Kirmizialtin, Olivier Siri, Ali Trabolsi

ACS Applied Materials & Interfaces (2022)10.1021/acsami.2c06841

A one-dimensional high-order commensurate phase of tilted molecules

Anthony Thomas, Thomas Leoni, Olivier Siri, Conrad Becker, Martin Unzog, Christian Kern, Peter Puschnig, Peter Zeppenfeld

Physical Chemistry Chemical Physics 24:9118-9122 (2022)10.1039/d2cp00437b

Optoelectronic properties of a self-assembling rigidly-linked BF2-curcuminoid bichromophore

Claire Tonnelé, Manon Catherin, Michel Giorgi, Gabriel Canard, David Casanova, Frédéric Castet, Elena Zaborova, Frédéric Fages

Dyes and Pigments 207:110677 (2022)10.1016/j.dyepig.2022.110677

Small Activating RNA Modulation of the G Protein‐Coupled Receptor for Cancer Treatment

Yunfang Xiong, Ran Ke, Qingyu Zhang, Wenjun Lan, Wanjun Yuan, Karol Nga Ieng Chan, Tom Roussel, Yifan Jiang, Jing Wu, Shuai Liu, Alice Sze Tsai Wong, Joong Sup Shim, Xuanjun Zhang, Ruiyu Xie, Nelson Dusetti, Juan Iovanna, Nagy Habib, Ling Peng, Leo Tsz On Lee

Advanced Science 2200562 (2022)10.1002/advs.202200562

Bola‐Amphiphilic Glycodendrimers: New Carbohydrate Mimicking Scaffolds to Target Carbohydrate‐Binding Proteins

Wenzheng Zhang, Dinesh Dhumal, Xiaolei Zhu, Brigino Ralahy, Aleksandra Ellert-Miklaszewska, Jing Wu, Erik Laurini, Yi-Wen W Yao, Chai-Lin L Kao, Juan L Iovanna, Sabrina Pricl, Bozena Kaminska, Yi Xia, Ling Peng

Chemistry - A European Journal (2022)10.1002/chem.202201400


Organic-Inorganic doped Nickel Oxide Nanocrystals for Hole Transport Layers in Inverted Polymer Solar Cells with Color Tuning

Riva Alkarsifi, Yatzil Alejandra Avalos-Quiroz, Pavlo Perkhun, Xianjie Liu, Mats Fahlman, Anil Kumar Bharwal, Carmen M. Ruiz, David Duché, Jean-Jacques Simon, Christine Videlot-Ackermann, Olivier Margeat, Jörg Ackermann

Materials Chemistry Frontiers (2021)

Non-Fullerene Acceptors with an Extended Pi-Conjugated Core: Third Components in Ternary Blends for High-Efficiency, Post Treatment-Free, Organic Solar Cells

Yatzil Alejandra Avalos Quiroz, Olivier Bardagot, Yann Kervella, Cyril Aumaître, Lydia Cabau, Agnès Rivaton, Olivier Margeat, Christine Videlot-Ackermann, Uyxing Vongsaysy, Jörg Ackermann, Renaud Demadrille

ChemSusChem 14:3502-3510 (2021)10.1002/cssc.202101005

Electronic and magnetic properties of metal–organic polymers with 4d and 5d-transition metal ions

Hassan Denawi, Mathieu Abel, Olivier Siri, Roland Hayn

Journal of Magnetism and Magnetic Materials 537:168183 (2021)10.1016/j.jmmm.2021.168183

An ionizable supramolecular dendrimer nanosystem for effective siRNA delivery with a favorable safety profile

Dinesh Dhumal, Wenjun Lan, Ling Ding, Yifan Jiang, Zhenbin Lyu, Erik Laurini, Domenico Marson, Aura Tintaru, Nelson Dusetti, Suzanne Giorgio, Juan Lucio Iovanna, Sabrina Pricl, Ling Peng

Nano Research (2021)10.1007/s12274-020-3216-8

Functionalized porphyrins from meso-poly-halogeno-alkyl-dipyrromethanes: synthesis and characterization

Paul-Gabriel Julliard, Simon Pascal, Olivier Siri, Diego Cortés-Arriagada, Luis Sanhueza, G. Canard

Comptes Rendus. Chimie 24:1-19 (2021)10.5802/crchim.97

High‐Efficiency Digital Inkjet‐Printed Non‐Fullerene Polymer Blends Using Non‐Halogenated Solvents

Pavlo Perkhun, Wolfgang Köntges, Florent Pourcin, Daniel Esteoulle, Elena Barulina, Noriyuki Yoshimoto, Pascal Pierron, Olivier Margeat, Christine Videlot-Ackermann, Anil Kumar Bharwal, David Duché, Carmen Ruiz Herrero, Cedric Gonzales, Antonio Guerrero, Juan Bisquert, Rasmus Schröder, Martin Pfannmöller, Sadok Ben Dkhil, Jean-Jacques Simon, Jörg Ackermann

Advanced Energy and Sustainability Research 2000086 (2021)10.1002/aesr.202000086

Design of Inhibitors of the Intrinsically Disordered Protein NUPR1: Balance between Drug Affinity and Target Function

Bruno Rizzuti, Wenjun Lan, Patricia Santofimia-Castaño, Zhengwei Zhou, Adrián Velázquez-Campoy, Olga Abián, Ling Peng, José Neira, Yi Xia, Juan Iovanna

Biomolecules 11:1453 (2021)10.3390/biom11101453

Nucleoside-Lipid-Based Nanoparticles for Phenazine Delivery: A New Therapeutic Strategy to Disrupt Hsp27-eIF4E Interaction in Castration Resistant Prostate Cancer

Hajer Ziouziou, Clément Paris, Sébastien Benizri, Thi Khanh Le, Claudia Andrieu, Dang Tan Nguyen, Ananda Appavoo, David Taïeb, Frédéric Brunel, Ridha Oueslati, Olivier Siri, Michel Camplo, Philippe Barthélémy, Palma Rocchi

Pharmaceutics 13:623 (2021)10.3390/pharmaceutics13050623


Équipe Ackermann 1 Sources et sondes ponctuelles 2 Physique et nano-micro Ingénierie pour le Vivant 1 Équipe Peng Équipe Peng 1

  • ANR contracts

  • 1 Doc2AMU fellowship

  • 1 collaboration contract with Dracula Technologie company

  • 1 AMidex project

  • 1 "Ligue contre le Cancer" labeled team

  • 2 Horizon 2020 contracts