Nadine Candoni

Axe

Sources et Sondes Ponctuelles

E-mail

nadine.candoni@univ-amu.fr

Phone

+33(0)6 17 24 80 87

Localisation

L3

Grade

PU1

Fonction

enseignant - chercheur

Pièce

313

candoni.jpg

Activity

microfluidique, cristallisation, gélification, nucléation, croissance, biologique, biomédical, AFM ; physico-chimie/surface ; nanoparticules ; biomolécules : ADN, protéines ; jonction brisée : or, molécule unique ; hydrodynamique ; mouillage

Thèmes

RESEARCH INTERESTS AND ACTIVITIES

13 Thesis and Master2 internships

45 publications including 1 patent, 2 ANR projects and 2 CIFRE contracts

50 international and national conferences including 17 as a guest speaker

2009- Reactions in nanovolumes using droplet-based microfluidic systems :

  • Crystallization studies for pharmaceutical and biological applications
  • Jellification to mimic red blood cells for biomedical applications

2007-2012      Conductance measurement on single molecules

2000-2007      AFM and Colorimetric Detection of DNA hybridization (ex-GPEC)

1998 - 2000    Physico-chemical studies of viscous pulverizations (Renault)

1995-1998   Forced Dynamic wetting of agrochemical emulsions(CNRS/Rhodia)

Recherche

RESEARCH INTERESTS AND ACTIVITIES since 2009                 

Development of droplet-based microfluidic systems tu study reactions in nanovolumes :

  1. Crystallization studies for pharmaceutical and biological applications
  2. Jellification to mimic red blood cells for biomedical applications

Parcours

CAREER: CNU -28ème section  “Milieux denses et Matériaux”

2018-          Full Professor 1st class, Polytech-Aix-Marseille Université / CINaM 

2015-          Head of the Dept of Biomedical Engineering-Polytech Marseille

2013-2018   Full Professor 2nd class, Polytech-Aix-Marseille Université / CINaM 

2000-2013   Assistant Professor Polytech-Aix-Marseille Université / CINaM

1998-2000   Post-Doc - CNRS & Company Renault

1995-1998   PhD Thesis - Lab. of Transport Phenomena in Mixed Media / CNRS

EDUCATION

2010   Habilitation Thesis : “Detection and physico-chemistry of single objects” 

1998   PhD thesis : Forced Dynamic wetting of agrochemical emulsions

1993-1994 Master Degree in Condensed Matter - Paris VI

1989-1992  Engineer in Physics and Chemistry-Engineering School of Bordeaux

Publications

2023

Exploring the World of Membrane Proteins: Techniques and Methods for Understanding Structure, Function, and Dynamics

Imad Boulos, Joy Jabbour, Serena Khoury, Nehme Mikhael, Victoria Tishkova, Nadine Candoni, Hilda E Ghadieh, Stéphane Veesler, Youssef Bassim, Sami Azar, Frédéric Harb

Molecules 28:7176 (2023)10.3390/molecules28207176

CNT effective interfacial energy and pre-exponential kinetic factor from measured NaCl crystal nucleation time distributions in contracting microdroplets

Ruel Cedeno, Romain Grossier, Nadine Candoni, Nicolas Levernier, Adrian Flood, Stéphane Veesler

Journal of Chemical Physics 158:194705 (2023)10.1063/5.0143704

Microdroplet Approach for Measuring Aqueous Solubility and Nucleation Kinetics of a Metastable Polymorph: The case of KDP Phase IV

Ruel Cedeno, Romain Grossier, Nadine Candoni, Stéphane Veesler

Crystal Growth & Design (2023)

Modular microfluidic platform for solubility measurement, nucleation statistics and polymorph screening of active pharmaceutical ingredients: Irbesartan, Rimonabant, Aripiprazole and Sulfathiazole

Mathilde Lambert, Romain Grossier, Mehdi Lagaize, Thirou Bactivelane, Vasile Heresanu, Benoît Robert, Nadine Candoni, Stéphane Veesler

Journal of Crystal Growth 616:127252 (2023)

2022

Evaporation Dynamics of Sessile Saline Microdroplets in Oil

Ruel Cedeno, Romain Grossier, Victoria Tishkova, Nadine Candoni, Adrian E. Flood, Stéphane Veesler

Langmuir 38:9686-9696 (2022)10.1021/acs.langmuir.2c01269

Nucleation in Sessile Saline Microdroplets: Induction Time Measurement via Deliquescence-Recrystallization Cycling

Ruel Cedeno, Romain A Grossier, Mehdi Lagaize, D. Nerini, Nadine Candoni, A. E. Flood, Stéphane Veesler

Faraday Discussions 183-197 (2022)10.1039/D1FD00090J

2021

2020

Microfluidics platform for polymorph screening directly from powder

Guillem Peybernès, Romain Grossier, Frédéric Villard, Philippe Letellier, Nadine Candoni, Stéphane Veesler

Crystal Growth & Design 20:3882-3887 (2020)

A microfluidic method generating monodispersed microparticles with controllable sizes and mechanical properties

Cheng Zhang, Romain A Grossier, Leda Lacaria, Felix Rico, Nadine A Candoni, Stéphane A Veesler

Chemical Engineering Science 211:115322 (2020)10.1016/j.ces.2019.115322

2019

Advances in the Use of Microfluidics to Study Crystallization Fundamentals

Nadine A Candoni, Romain Grossier, Mehdi Lagaize, Stéphane Veesler

Annual Review of Chemical and Biomolecular Engineering 10:59-83 (2019)10.1146/annurev-chembioeng-060718-030312

Multiscale Experimental Study and Modeling of l -Glutamic acid Crystallization: Emphasis on a Kinetic Explanation of the Ostwald Rule of Stages

Yousra Tahri, Emilie Gagnière, Elodie Chabanon, Tijani Bounahmidi, Zdeněk Kožíšek, Nadine Candoni, Stéphane Veesler, Moussa Boukerche, Denis Mangin

Crystal Growth & Design 19:3329-337 (2019)10.1021/acs.cgd.9b00217

2018

A chemical library to screen protein and protein-ligand crystallization using a versatile microfluidic platform

Charline J. J. Gerard, Gilles Ferry, Laurent M Vuillard, Jean A. Boutin, Nathalie A Ferte, Romain A Grossier, Nadine A Candoni, Stéphane A Veesler

Crystal Growth & Design 18:5130-5137 (2018)10.1021/acs.cgd.8b00572

Microfluidics set-up rapidly measures solubility directly from powder

Guillem Peybernès, Romain A Grossier, Frédéric Villard, Philippe Letellier, Mehdi Lagaize, Nadine A Candoni, Stéphane Veesler

Organic Process Research and Development 22:1856-1860 (2018)10.1021/acs.oprd.8b00300

2017

Crystallization via tubing microfluidics permits both in situ and ex situ X-ray diffraction

Charline J. J. Gerard, Gilles Ferry, Laurent M Vuillard, Jean A Boutin, Léonard M.G. Chavas, Tiphaine Huet, Nathalie A Ferte, Romain A Grossier, Nadine Candoni, Stéphane Veesler

Acta crystallographica Section F : Structural biology communications [2014-...] 73:574-578 (2017)10.1107/S2053230X17013826

Microfluidic platform for optimization of crystallization conditions

Shuheng A Zhang, Charline J. J. Gerard, Aziza A Ikni, Gilles Ferry, Laurent M Vuillard, Jean A. Boutin, Nathalie A Ferte, Romain A Grossier, Nadine A Candoni, Stéphane A Veesler

Journal of Crystal Growth 472:18-28 (2017)10.1016/j.jcrysgro.2017.01.026

2016

Factors affecting the viscosity of sodium hypochlorite and their effect on irrigant flow

F. Bukiet, T. Soler, M. Guivarc'H, J. Camps, H. Tassery, F. Cuisinier, N. Candoni

International Endodontic Journal 49:912 (2016)10.1111/iej.12673

2015

Localizing and inducing primary nucleation

Z. Hammadi, R. Grossier, Aziza Ikni, N. Candoni, R. Morin, S. Veesler

Faraday Discussions 179:489-501 (2015)10.1039/c4fd00274a

Versatile Microfluidic Approach to Crystallization

S. Zhang, N. Ferte, N. Candoni, S. Veesler

Organic Process Research and Development 19:1837-1841 (2015)10.1021/acs.oprd.5b00122

Prediction of sizes and frequencies of nanoliter-sized droplets in cylindrical T-junction microfluidics

Shuheng Zhang, Carine Guivier-Curien, Stéphane Veesler, Nadine Candoni

Chemical Engineering Science 138:128-139 (2015)10.1016/j.ces.2015.07.046

Prediction of sizes and frequencies of nanoliter-sized droplets in cylindrical T-junction microfluidics

Shuheng Zhang, Carine Guivier-Curien, Stéphane Veesler, Nadine Candoni

Chemical Engineering Science 138:128-139 (2015)10.1016/j.ces.2015.07.046

2014

Transient calcium carbonate hexahydrate (Ikaite) nucleated and stabilized in confined nano- and picovolumes

I. Rodríguez-Ruiz, S. Veesler, J. Gómez-Morales, J.M. Delgado-López, O. Grauby, Z. Hammadi, N. Candoni, J.M. García-Ruiz

Crystal Growth & Design 14:792-802 (2014)

2013

Statistical evidence of strain induced breaking of metallic point contacts

M Alwan, N R Candoni, Philippe Dumas, H R Klein

The European Physical Journal B: Condensed Matter and Complex Systems 86:243 (2013)10.1140/epjb/e2013-40040-5

Statistical evidence of strain induced breaking of metallic point contacts

Monzer Alwan, Nadine Candoni, Philippe Dumas, Hubert Klein

The European Physical Journal B: Condensed Matter and Complex Systems 86:243 (2013)10.1140/epjb/e2013-40040-5

Small-volumes nucleation

Z. Hammadi, N. Candoni, R. Grossier, Manuel Ildefonso, R. Morin, S. Veesler

Comptes Rendus. Physique 14:192-198 (2013)

Small-volume nucleation

Zoubida Hammadi, Nadine Candoni, Romain Grossier, Manuel Ildefonso, Roger Morin, Stéphane Veesler

Comptes Rendus. Physique 14:192-198 (2013)10.1016/j.crhy.2012.12.004

Heterogeneous nucleation in droplet-based nucleation measurements

Manuel Ildefonso, N. Candoni, S. Veesler

Crystal Growth & Design 13:2107-2110 (2013)

2012

Wetting Properties and Critical Micellar Concentration of Benzalkonium Chloride Mixed in Sodium Hypochlorite

F. Bukiet, G. Couderc, J. Camps, H. Tassery, F. Cuisinier, I. About, A. Charrier, N. Candoni

Journal of Endodontics 38:1525-1529 (2012)

Nanotechnologies dedicated to nucleation control

N. Candoni, R. Grossier, Manuel Ildefonso, E. Revalor, N. Ferté, T. Okutsu, R. Morin, S. Veesler

International Journal of Nanotechnology 9:439-459 (2012)

A Cheap, Easy Microfluidic Crystallization Device Ensuring Universal Solvent Compatibility

Manuel Ildefonso, N. Candoni, S. Veesler

Organic Process Research and Development 16:556-560 (2012)10.1021/op200291z

Importance of Solvent Selection for Stoichiometrically Diverse Cocrystal Systems: Caffeine/Maleic Acid 1:1 and 2:1 Cocrystals

T. Leyssens, G. Springuel, R. Montis, N. Candoni, S. Veesler

Crystal Growth & Design 12:1520-1530 (2012)