Thi Khanh Le, Chaïma Cherif, Kenneth Omabe, Clément Paris, François Lannes, Stéphane Audebert, Emilie Baudelet, Mourad Hamimed, Dominique Barbolosi, Pascal Finetti, Cyrille Bastide, Ladan Fazli, Martin Gleave, François Bertucci, David Taïeb, Palma Rocchi

Molecular Therapy 31:471-486 (2023)10.1016/j.ymthe.2022.08.005

2022

HSP27/Menin Expression as New Prognostic Serum Biomarkers of Prostate Cancer Aggressiveness Independent of PSA

Asma Bourefis, Hajira Berredjem, Omar Djeffal, Thi Khanh Le, Sophie Giusiano, Palma Rocchi

Cancers 14 (2022)10.3390/cancers14194773

Menin inhibition suppresses castration-resistant prostate cancer and enhances chemosensitivity

Chaïma Cherif, Dang Tan Nguyen, Clément Paris, Thi Khanh Le, Thibaud Sefiane, Nadine Carbuccia, Pascal Finetti, Max Chaffanet, Abdessamad El Kaoutari, Julien Vernerey, Ladan Fazli, Martin Gleave, Mohamed Manai, Philippe Barthélémy, Daniel Birnbaum, François Bertucci, David Taïeb, Palma Rocchi

Oncogene 41:125-137 (2022)10.1038/s41388-021-02039-2

2021

Hydrogel based lipid-oligonucleotides: a new route to self-delivery of therapeutic sequences

Sébastien Benizri, Alexandra Gaubert, Charlotte Soulard, Étienne Gontier, Isabelle Svahn, Palma Rocchi, Gaëlle Vacher, Philippe Barthélémy

Biomaterials Science 9:3638-3644 (2021)10.1039/d1bm00273b

Nucleic Acid-Based Technologies Targeting Coronaviruses

Thi Khanh Le, Clément Paris, Khadija Shahed Khan, Fran Robson, Wai-Lung Ng, Palma Rocchi

Trends in Biochemical Sciences 46:351-365 (2021)10.1016/j.tibs.2020.11.010

Nucleic Acid-Based Technologies Targeting Coronaviruses

Thi Khanh Le, Clément Paris, Khadija Shahed Khan, Fran Robson, Wai-Lung Ng, Palma Rocchi

Trends in Biochemical Sciences 46:351-365 (2021)10.1016/j.tibs.2020.11.010

Antisense Oligonucleotide-Based Therapeutic against Menin for Triple-Negative Breast Cancer Treatment

Dang Tan Nguyen, Thi Khanh Le, Clément Paris, Chaïma Cherif, Stéphane Audebert, Sandra Oluchi Udu-Ituma, Sébastien Benizri, Philippe Barthélémy, François Bertucci, David Taïeb, Palma Rocchi

Biomedicines 9:795 (2021)10.3390/biomedicines9070795

Nanovectorization of Prostate Cancer Treatment Strategies: A New Approach to Improved Outcomes

Kenneth Omabe, Clément Paris, François Lannes, David Taïeb, Palma Rocchi

Pharmaceutics 13:591 (2021)10.3390/pharmaceutics13050591

Nucleoside-Lipid-Based Nanoparticles for Phenazine Delivery: A New Therapeutic Strategy to Disrupt Hsp27-eIF4E Interaction in Castration Resistant Prostate Cancer

Hajer Ziouziou, Clément Paris, Sébastien Benizri, Thi Khanh Le, Claudia Andrieu, Dang Tan Nguyen, Ananda Appavoo, David Taïeb, Frédéric Brunel, Ridha Oueslati, Olivier Siri, Michel Camplo, Philippe Barthélémy, Palma Rocchi

Pharmaceutics 13:623 (2021)10.3390/pharmaceutics13050623

2020

Self-assembly of amphiphilic phospholipid peptide dendrimer-based nanovectors for effective delivery of siRNA therapeutics in prostate cancer therapy

Yiwen Dong, Yu Chen, Dandan Zhu, Kangjie Shi, Chi Ma, Wenjie Zhang, Palma Rocchi, Lei Jiang, Xiaoxuan Liu

Journal of Controlled Release 322:416-425 (2020)10.1016/j.jconrel.2020.04.003

Coronavirus RNA Proofreading: Molecular Basis and Therapeutic Targeting

Fran Robson, Khadija Shahed Khan, Thi Khanh Le, Clément Paris, Sinem Demirbag, Peter Barfuss, Palma Rocchi, Wai-Lung Ng

Molecular Cell 79:710-727 (2020)10.1016/j.molcel.2020.07.027

Enhanced Antisense Oligonucleotide Delivery Using Cationic Liposomes Grafted with Trastuzumab: A Proof-of-Concept Study in Prostate Cancer

Guillaume Sicard, Clément Paris, Sarah Giacometti, Anne Rodallec, Joseph Ciccolini, Palma Rocchi, Raphaëlle Fanciullino

Pharmaceutics 12:1166 (2020)10.3390/pharmaceutics12121166

2019

Integrative proteomic and phosphoproteomic profiling of prostate cell lines

Maria Katsogiannou, Jean-Baptiste Boyer, Alberto Valdeolivas, Elisabeth Remy, Laurence Calzone, Stéphane Audebert, Palma Rocchi, Luc Camoin, Anaïs Baudot

PLoS ONE 14:e0224148 (2019)10.1371/journal.pone.0224148

2018

A Dual Targeting Dendrimer-Mediated siRNA Delivery System for Effective Gene Silencing in Cancer Therapy

Yiwen Dong, Tianzhu Yu, Ling Ding, Erik Laurini, Yuanyu Huang, Mengjie Zhang, Yuhua Weng, Shuting Lin, Peng Chen, Domenico Marson, Yifan Jiang, Suzanne Giorgio, Sabrina Pricl, Xiaoxuan Liu, Palma Rocchi, Ling Peng

Journal of the American Chemical Society 140:16264-16274 (2018)10.1021/jacs.8b10021

PSMA-Targeted Radionuclide Therapy and Salivary Gland Toxicity: Why Does It Matter?

David Taïeb, Jean-Marc Foletti, Manuel Bardiès, Palma Rocchi, Rodney Hicks, Uwe Haberkorn

Journal of Nuclear Medicine 59:747-748 (2018)10.2967/jnumed.118.207993

Correction: Targeting Hsp27/eIF4E interaction with phenazine compound: a promising alternative for castration-resistant prostate cancer treatment

Hajer Ziouziou, Claudia Andrieu, Erik Laurini, Sara Karaki, Maurizio Fermeglia, Ridha Oueslati, David Taieb, Michel Camplo, Olivier Siri, Sabrina Pricl, Maria Katsogiannou, Palma Rocchi

Oncotarget 9:28797-28797 (2018)10.18632/oncotarget.25683

2017

Lipid-oligonucleotide conjugates improve cellular uptake and efficiency of TCTP-antisense in castration-resistant prostate cancer

Sara Karaki, Sebastien Benizri, Raquel Mejías, Virginie Baylot, Nicolas Branger, Tan Nguyen, Brune Vialet, Khalid Oumzil, Philippe Barthélémy, Palma Rocchi

Journal of Controlled Release 258:Epub ahead of print, 1-9 (2017)10.1016/j.jconrel.2017.04.042

Targeting Hsp27/eIF4E interaction with phenazine compound: a promising alternative for castration-resistant prostate cancer treatment

Hajer Ziouziou, Claudia V. Andrieu, Erik Laurini, Sara Karaki, Maurizio Fermeglia, Ridha Oueslati, David Taieb, Michel Camplo, Olivier Siri, Sabrina Pricl, Maria Katsogiannou, Palma Rocchi

Oncotarget 8:77317-77329 (2017)10.18632/oncotarget.20469

2016

Mastering Dendrimer Self-Assembly for Efficient siRNA Delivery: From Conceptual Design to In Vivo Efficient Gene Silencing

Chao Chen, Paola Posocco, Xiaoxuan Liu, Qiang Cheng, Erik Laurini, Jiehua Zhou, Cheng Liu, Yang Wang, Jingjie Tang, Valentina Dal Col, Tianzhu Yu, Suzanne Giorgio, Maurizio Fermeglia, Fanqi Qu, Zicai Liang, John J. Rossi, Minghua Liu, Palma Rocchi, Sabrina Pricl, Ling Peng

Small 12:3667-3676 (2016)10.1002/smll.201503866

A Fluorinated Bola-Amphiphilic Dendrimer for On-Demand Delivery of siRNA, via Specific Response to Reactive Oxygen Species

Xiaoxuan Liu, Yang Wang, Chao Chen, Aura Tintaru, Yu Cao, Juan Liu, Fabio Ziarelli, Jingjie Tang, Hongbo Guo, Roseline Rosas, Suzanne Giorgio, Laurence Charles, Palma Rocchi, Ling Peng

Advanced Functional Materials 26:8594-8603 (2016)10.1002/adfm.201604192

Inherent and Tumor-Driven Immune Tolerance in the Prostate Microenvironment Impairs Natural Killer Cell Antitumor Activity

Christine Pasero, Gwenaëlle Gravis, Mathilde Guerin, Samuel Granjeaud, Jeanne Thomassin-Piana, Palma Rocchi, Maria Paciencia-Gros, Flora Poizat, Mélanie Bentobji, Francine Azario-Cheillan, Jochen Walz, Naji Salem, Serge Brunelle, Alessandro Moretta, Daniel Olive

Cancer Research 76:2153-2165 (2016)10.1158/0008-5472.CAN-15-1965

2014

The functional landscape of Hsp27 reveals new cellular processes such as DNA repair and alternative splicing and proposes novel anticancer targets.

Maria Katsogiannou, Claudia Andrieu, Virginie Baylot, Anaïs Baudot, Nelson J Dusetti, Odile Gayet, Pascal Finetti, Carmen Garrido, Daniel Birnbaum, François Bertucci, Christine Brun, Palma Rocchi

Molecular and Cellular Proteomics 3585-601 (2014)10.1074/mcp.M114.041228

2012

A Novel Bitriazolyl Acyclonucleoside Endowed with Dual Antiproliferative and Immunomodulatory Activity

Yi Xia, Menghua Wang, Olivier Demaria, Jingjie Tang, Palma Rocchi, Fanqi Qu, Juan Iovanna, Lena Alexopoulou, Ling Peng

Journal of Medicinal Chemistry 55:5642-5646 (2012)10.1021/jm300534u

2004

Molecular analysis integrating different pathways associated with androgen-independent progression in LuCaP 23.1 xenograft

Palma Rocchi, Xavier Muracciole, Frederic Fina, Dave Mulholland, Gilles Karsenty, Jacqueline Palmari, L'Houcine Ouafik, Franck Bladou, Pierre-Marie Martin

Oncogene 23:9111-9119 (2004)10.1038/sj.onc.1208154

2001

Expression of adrenomedullin and peptide amidation activity in human prostate cancer and in human prostate cancer cell lines.

Palma Rocchi, Françoise Boudouresque, Alfredo J. Zamora, Xavier Muracciole, Eric Lechevallier, Pierre-Marie Martin, L'Houcine Ouafik

Cancer Research 1196-206 (2001)