Novel and innovative interface as potential active layer in Chem-FET sensor devices for the specific sensing of Cs+

Volkan Kilinc, Catherine Henry-de-Villeneuve, Tin Phan Nguy, Yutaka Wakayama, Anne M. Charrier, Jean-Manuel Raimundo

ACS Appl. Mater. Interfaces, 2019, DOI: 10.1021/acsami.9b18188

The introduction of microfabrication techniques into the field of analytical sensors has recently lead to tremendous development of microfabricated devices notably for monitoring hazardous and/or harmful analyte traces. These devices are not only designed and suitable for environmental purposes, ion trace quantification, but are also of great of importance to direct assess biological samples in the field of in vitro or in vivo diagnostics and food processing. To this aim field effect transistors fulfill the needed requirements in the field of electrical sensor technologies and offer unique characteristics such as miniaturization, low-cost, ease-of-use, low limit of detection, selectivity, and real-time monitoring capabilities at the point-of-need. The development of such devices requires efficient transducers exhibiting high specificities and selectivities.

We have recently demonstrated that engineered single lipids monolayers (SLM) can be used as ultrathin dielectric leading to sensing properties with limits of detection down to the femtomole in Chem-FET sensors when they are functionalized with specific probes. In line with our previous work, we have developed an innovative interface made from functionalized SLM tethered with a novel 1,3-alternated calix[4]arene host exhibiting high selectivity toward the foreseen Cs⁺ analyte that can be used in Chem-FET sensor devices.

This research was performed under the framework of the Strategic International Collaborative Research Program (SICORP) and financially supported by the Japan Science and Technology Agency (JST) and l’Agence Nationale de la Recherche (ANR). Project No. ANR-16- JTIC-0003-01.

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Contact :

Dr. Anne M. Charrier, Email: charrier@cinam.univ-mrs.fr

Pr Jean-Manuel Raimundo, Email: jean-manuel.raimundo@univ-amu.fr

Aix-Marseille Université, CNRS, Centre Interdisciplinaire de Nanoscience de Marseille (CINaM) UMR 7325