Sensors for health and environment

Leader: A. Charrier, C. Fauquet, F. Thibaudau, D. Tonneau


Dosimeters for small-field radiation therapy

Principal investigators: C. Fauquet, D. Tonneau
PostDoc S. Debnath

We designed and fabricated smart X-Rays sensors for applications in radiation therapy (collaboration with Institute Paoli Calmettes, Marseille, France). The dosimeter is based on inorganic scintillators grafted at the extremity of an optical fibre (Fig.1). The visible light emitted by the scintillators is guided to a photon counter. The dosimeter is extremely stable and reliable and easy to calibrate. Because of the tiny interaction volume of this device with the irradiation field, this dosimeter affords a true improvement in comparison with those commercially available. Indeed, we could characterize with a very high accuracy small irradiation fields (below 5x5 mm²) needed for early stage cancer treatment. The dosimeter is particularly convenient for brachytherapy and we were able to demonstrate accurate dose measurement at a very small distances from the source (down to 200 µm), as well as high sensitivity at very large distances (up 5 cm from the source) (Fig. 2). The irradiation time during treatment was also measured with a high accuracy.

Nanostructured films of TCO for energetical and environmental applications.

Principal investigators: C. Fauquet, D. Tonneau

Collaboration: Laboratoire des Sciences de la Matière Condensée (LSMC), Oran 1 University, Algeria.

We collaborate with the LSMC lab, specialized in Transparent Conductive Oxide nanofilms elaboration and characterization, for fabrication of high efficiency photovoltaic cells  and highly sensitive gas sensors. The originality is in the elaboration methods, like hydrothermal growth or spray-pyrolysis, that can be handled at low temperatures and require little amount of reagents. These nanomaterials present numerous oxygen defects and active sites on their surface, due to their high surface/volume ratio. Recently, we demonstrated their high efficiency on the photodegradation of methylene blue, often released in the wastewater of textile industry (Fig. 4). Because this process only necessitates solar energy, it looks very promising.

Ingénierie des couches lipidiques et leurs propriétés physiques

Principal investigators: A. Charrier

PhD Student: USTH, doctoral grant
Collaborations: J.-M. raimundo, IMMF et M. Petit, NM, CINaM ; Y. Wakayama, NIMS, Japan, C. Henry-De-Villeneuve, LPMC,

Les couches lipidiques souvent utilisées comme système modèle des membranes cellulaires possèdent des propriétés intrinsèques (fluidité latérale, propriétés diélectrique) qui en font un matériau d’intérêt pour les applications. Les propriétés diélectriques naturelles de ces couches proviennent à la fois de leurs longues chaînes aliphatiques qui constituent une barrière au transport électronique mais aussi de leur haute densité moléculaire. Celle-ci est obtenue par l’auto-organisation spontanée des lipides mis en milieu aqueux sous forme de vésicules du fait de leurs propriétés amphiphiles. En couplant ingénierie moléculaire des lipides, et optimisation des procédés de dépôt sur substrat nous fabriquons des couches extrêmement denses, quasi-cristallines, stables mécaniquement, et aux propriétés d’isolant électrique tout à fait remarquables pour une couche de quelques nanomètres d’épaisseur. Nous nous intéressons aux interfaces constitués de cette couche avec des substrats organiques ou inorganiques et étudions les propriétés physiques de ces interfaces (organisation structurale, propriétés électriques et mécaniques.


OFET sensors for ion detection in complex media

Principle Investigator: A. Charrier

Organic field effect transistors (OFETs) are gaining interest for their potential applications in low-cost and flexible electronics. While most studies have focused on optimizing the mobility of organic semiconductor carriers (OSL), the choice of the gate dielectric (ODL) is also very important to minimize the density of electrical traps at the ODL/OSL interface. Most polymers already in use suffer from large leakage currents that are compensated for by increasing the thickness of the material, usually by several hundred nanometers or even microns. The disadvantage of this is the large operating voltage required to operate the transistor, with operating voltages ranging from a few volts to tens of volts. This can lead to heating of the device and possible damage to the organic materials and loss of performance. Moreover, in the more specific field of OFET sensors, a high operating voltage is a disadvantage for a high sensitivity and for reaching a low detection limit.
The originality of the project lies in the use of a lipid monolayer as a gate dielectric. With a thickness of a few nanometers and exceptional electrical insulating properties, this layer allows to use low working voltages while limiting leakage currents. The optimization of the ODL/OSL interfaces allows to reach extremely low detection limits in the attomolar range. We also develop original methods to reach high selectivity.The originality of the project lies in the use of a lipid monolayer as a gate dielectric. With a thickness of a few nanometers and exceptional electrical insulating properties, this layer allows the use of low working voltages while limiting leakage currents. The optimization of the ODL/OSL interfaces allows to reach extremely low detection limits in the attomolar range. We also develop original methods to reach high selectivity.






Classification of red cell dynamics with convolutional and recurrent neural networks: a sickle cell disease case study

Maxime Darrin, Ashwin Samudre, Maxime Sahun, Scott Atwell, Catherine Badens, Anne Charrier, Emmanuèle Helfer, Annie Viallat, Vincent Cohen-Addad, Sophie Giffard-Roisin

Scientific Reports 13:745 (2023)10.1038/s41598-023-27718-w

Physical mechanisms of red blood cell splenic filtration

Alexis Moreau, François Yaya, Huije Lu, Anagha Surendranath, Anne Charrier, Benoit Dehapiot, Emmanuèle Helfer, Annie Viallat, Zhangli Peng

Proceedings of the National Academy of Sciences of the United States of America (2023)10.1101/2023.01.10.523245


Synthesis and Investigation of Pure and Cu-Doped NiO Nanofilms for Future Applications in Wastewater Treatment Rejected by Textile Industry

Malika Allali, Mohamed Amine Dahamni, Mostefa Ghamnia, Abdelwahab Boukhachem, Djamel Boukrédimi, Didier Tonneau, Carole Fauquet

Catalysts 12:931 (2022)10.3390/catal12090931

Characterization of Some Physical and Photocatalytic Properties of CuO Nanofilms Synthesized by a Gentle Chemical Technique

Soumia Aroussi, Mohamed Amine Dahamni, Mostefa Ghamnia, Didier Tonneau, Carole Fauquet

Condensed Matter 7:37 (2022)10.3390/condmat7020037

Dynamics of Individual Red Blood Cells Under Shear Flow: A Way to Discriminate Deformability Alterations

Scott Atwell, Catherine Badens, Anne Charrier, Emmanuèle Helfer, Annie Viallat

Frontiers in Physiology 12 (2022)10.3389/fphys.2021.775584

Affinity driven ion exchange EG-OFET sensor for high selectivity and low limit of detection of Cesium in seawater

Tin Phan Nguy, Volkan Kilinc, Ryoma Hayakawa, Catherine Henry-De-Villeneuve, Jean-Manuel Raimundo, Yutaka Wakayama, Anne Charrier

Sensors and Actuators B: Chemical 351:130956 (2022)10.1016/j.snb.2021.130956


OC-0133 Dosimetric characterizations of a novel inorganic scintillating detector - HDR brachytherapy

S. B.C. Debnath, D. Tonneau, C. Fauquet, A. Tallet, A. Goncalves, M. Ferre, J. Darreon

Radiotherapy & Oncology 158:S99 (2021)10.1016/S0167-8140(21)06324-6

In situ plant materials hyperspectral imaging by multimodal scattering near-field optical microscopy

Anne Charrier, Aubin C Normand, Ali Passian, Philip Schaefer, Aude L. L. Lereu

Communications Materials 2:59 (2021)10.1038/s43246-021-00166-7

Spray Pyrolysis Synthesis of Pure and Mg-Doped Manganese Oxide Thin Films

Mohamed Amine Dahamni, Mostefa Ghamnia, Salah Eddine Naceri, Carole Fauquet, Didier Tonneau, Jean-Jacques Pireaux, Abed Bouadi

Coatings 11:598 (2021)10.3390/coatings11050598

Signal amplification of fiber integrated X-ray detector and energy independence

S.B.C. Debnath, J. Darreon, A. Tallet, A. Goncalves, D. Tonneau, C. Fauquet

IEEE Sensors Journal 1-1 (2021)10.1109/JSEN.2021.3091660

Dosimetric characterization of a small-scale (Zn,Cd)S:Ag inorganic scintillating detector to be used in radiotherapy

Sree Bash Chandra Debnath, Didier Tonneau, Carole Fauquet, Agnes Tallet, Anthony Goncalves, Julien Darreon

Physica Medica 84:15-23 (2021)10.1016/j.ejmp.2021.03.022

High resolution small‐scale inorganic scintillator detector: HDR brachytherapy application

Sree Bash Chandra Debnath, Marjorie Ferre, Didier Tonneau, Carole Fauquet, Agnes Tallet, Anthony Goncalves, Julien Darreon

Medical Physics (2021)10.1002/mp.14727

Signal Amplification of Fiber Integrated X-Ray Detector and Energy Independence

Sree Bash Chandra Debnath, Julien Darreon, Agnes Tallet, Anthony Goncalves, Didier Tonneau, Carole Fauquet

IEEE Sensors Journal 21:18793-18799 (2021)10.1109/JSEN.2021.3091660

Biomechanics as driver of aggregation of tethers in adherent membranes

Long Li, Mohammad Arif Kamal, Bernd Henning Stumpf, Franck Thibaudau, Kheya Sengupta, Ana-Sunčana Smith

Soft Matter 17:10101-10107 (2021)10.1039/d1sm00921d

Influence of force volume indentation parameters and processing method in wood cell walls nanomechanical studies

Aubin C Normand, Anne Charrier, Olivier Arnould, Aude L. Lereu

Scientific Reports 11:5739 (2021)10.1038/s41598-021-84994-0

Thermoplasmonics of metal layers and nanoholes

Benoit Rogez, Zakaria Marmri, Franck Thibaudau, Guillaume Baffou

APL Photonics 6:101101 (2021)10.1063/5.0057185

An Interactive micromanipulation station combined to a confocal XRF instrument : proof of concept and volume resolution

D. Tonneau, D. Renahy, S. Douillet, H. Maradj, C. Fauquet, F. Marchi

IEEEXplore Digital Library (2021)10.1109/MARSS49294.2020.9307924


Photocatalytical properties of NiO nanofilms doped with Ba

S. Boulila, M. Ghamnia, A. Boukhachem, A. Ouhaibi, M. Chakhoum, C. Fauquet, V. Heresanu, D. Tonneau

Philosophical Magazine Letters 100:283-293 (2020)10.1080/09500839.2020.1760389

Nanomechanics and Raman Spectroscopy of in Situ Native Carbohydrate Storage Granules for Enhancing Starch Quality and Lignocellulosic Biomass Production

Rubye Farahi, Aude L. Lereu, Anne Charrier, Udaya C Kalluri, Brian H Davison, Ali Passian

ACS Omega 5:2594−2602 (2020)10.1021/acsomega.9b02849

Femtomolar detection of Cu2+ ions in solution using super-Nernstian FET-sensor with a lipid monolayer as top-gate dielectric

A. Kenaan, F. Brunel, J.-M. Raimundo, Anne Charrier

Sensors and Actuators B: Chemical 316:128147 (2020)10.1016/j.snb.2020.128147

Electrolyte-gated-organic field effect transistors functionalized by lipid monolayers with tunable pH sensitivity for sensor applications

Tin Phan Nguy, Ryoma Hayakawa, Volkan Kilinc, Matthieu Petit, Yemineni S L V Narayana, Masayoshi Higuchi, Jean-Manuel Raimundo, Anne Charrier, Yutaka Wakayama

Applied Physics Express 13:011005 (2020)10.7567/1882-0786/ab5322


Investigation of Some Physical Properties of Cobalt Doped MoO3 Nanofilms and Their Effects on the Degradation of the Methylene Blue Solution under UV Illumination

N. Benameur, A. Boukhachem, M. Ghamnia, M. Chakhoum, M. Dahamni, C. Fauquet

International Journal of Chemical Engineering and Applications 10:33-39 (2019)10.18178/ijcea.2019.10.2.736

High spatial resolution inorganic scintillator detector for high energy X-ray beam at small field irradiation

S.B.C Debnath, Agnes Tallet, S. Lavandier, Sree Bash, Chandra Debnath, C. Fauquet, Agnès Tallet, Anthony Gonçalves, S Ebastien Lavandier, F. Jandard, D. Tonneau, Julien Darréon

Medical Physics (2019)10.1002/MP.14002

Structure of a Zn monolayer on Ag(111) and Ag(110) substrates: an AES, LEED and STM study

Maradj Hicham, Carole Fauquet, Mostefa Ghamnia, Benedicte Ealet, Nabil Rochdi, Sébastien Vizzini, Jean-Paul Biberian, Bernard Aufray, Haik Jamgotchian

Surface Science : A Journal Devoted to the Physics and Chemistry of Interfaces (2019)10.1016/j.susc.2019.02.007

Self-organization of red blood cell suspensions under confined 2D flows

Cécile Iss, Dorian Midou, Alexis Moreau, Delphine Held, Anne Charrier, Simon Mendez, Annie Viallat, Emmanuèle Helfer

Soft Matter (2019)10.1039/C8SM02571A

Novel and Innovative Interface as Potential Active Layer in Chem-FET Sensor Devices for the Specific Sensing of Cs+

Volkan Kilinc, Catherine Henry-De-Villeneuve, Tin Phan Nguy, Yutaka Wakayama, Anne M Charrier, Jean-Manuel Raimundo

ACS Applied Materials & Interfaces 11:47635-47641 (2019)10.1021/acsami.9b18188

Stable operation of water-gated organic field-effect transistor depending on channel flatness, electrode metals and surface treatment

Tin Phan Nguy, Ryoma Hayakawa, Volkan Kilinc, Matthieu Petit, Jean-Manuel Raimundo, Anne Charrier, Yutaka Wakayama

Japanese Journal of Applied Physics 58:SDDH02 (2019)10.7567/1347-4065/ab09d2


The effect of strontium doping on structural and morphological properties of ZnO nanofilms synthesized by ultrasonic spray pyrolysis method

A. Ouhaibi, M. Ghamnia, A. Dahamni, V. Heresanu, C. Fauquet, D. Tonneau

Journal of Science: Advanced Materials and Devices 3:29-36 (2018)10.1016/j.jsamd.2018.01.004