Ling Peng

Localisation

TPR1 - 4 étage

Grade

DR1

Fonction

chercheur

Pièce

G4.17

peng.jpg

Activité

dendrimers, drug delivery, nanobiotechnology, nanomedicine

Thèmes

1. Intelligent functional biomaterials for drug deliery based on dendrimer nanotechnology  

2. Molecular probes and chemical biology

3. Drug discovery based on triazole nucleoside chemistry

 

Recherche

Functional and intelligent biomaterials based on dendrimer nanotechnology: In order to treat various life-threatening diseases such as cancer, infection and neurodegenerative dementia, it is essential to develop efficient systems which enable precise diagnosis and effective treatment of diseases by delivering the right agents at the right sites with the right doses and timing. Dendrimers are the ideal delivery systems by virtue of their uniquely well-defined and precisely controlled structure with multivalent cooperativity confined within a nanosized volume. We are developing functional biocompatible dendrimer materials for bioimaging-based diagnosis, cancer treatment and gene therapy.

Molecular probes and chemical biology: Molecular probes are useful tools to study and understand biological events. We have designed and synthesized various molecular probes of phospholipids and of 2-oxoglutarate, an important intermediate of the Kreb’s cycle, with a view to studying biomembranes and the signaling roles and pathways of Kreb’s cycle intermediates in nitrogen fixation and cancer development.

Drug discovery based on triazole nucleoside chemistry: Nucleoside mimics are of great importance in the search for antiviral, anticancer and antibacterial drug candidates. One noteworthy example is ribavirin, the first synthetic triazole nucleoside showing antiviral activity against a broad spectrum of viruses. We have developed novel triazole nucleoside derivatives using modern green chemistry. Some of the lead compounds have shown excellent potency against drug-resistant cancers with novel modes of action such as targeting the heat shock response pathway, inducing autophagy and eliciting an immunomodulation effect etc.

 

Parcours

Dr. Ling Peng is a research director at the French National Scientific Research Center (CNRS) in France. She carried her undergraduate study in polymer chemistry with Prof. Chen Rongshi at Nanjing University in China, her PhD program in organic chemistry with Prof. Albert Eschenmoser at Swiss Federal Institute of Technology in Zurich, Switzerland, and her postdoctoral research in Pharmacy with Prof. Maurice Goeldner at Louis Pasteur University of Strasbourg in France. She was recruited as a research scientist in CNRS in 1997, promoted as a CNRS research director in 2008, and then 1st class Research Director in 2015.

Dr. Ling PENG has been working actively at the interface of chemistry and biology, and in particular, developing functional dendrimers for biomedical applications, molecular probes for exploring biological events and nucleoside analogues for drug discovery. She has established bio-inspired structurally flexible dendrimers for nucleic acid delivery. Recently, she has inaugurated the concept of self-assembling supramolecular dendrimers, and applied this concept to deliver various anticancer drugs, nucleic acid therapeutics and imaging agents for cancer treatment and imaging. Her research team has been labelled by La Ligue contre Le Cancer in France since 2016.

Dr. Ling PENG was awarded with the Prize of Dr & Mme Henri Labbé of the French Academy of Sciences in 2017 and the Distinguished Member of French Chemical Society in 2020.

Selected Publications:

1.    Chen J, Zhu D, Liu X, Peng L, “Amphiphilic dendrimer vectors for RNA delivery: state-of-the-art and future perspective”, Acc. Mater. Res. 2022, 3, 5, 484-497.

2.    Xiong Y, Ke R, Zhang Q, Lan W, Yuan W, Chan KNI, Roussel T, Jiang Y, Wu J, Liu S, Wong AST, Shim JS, Zhang X, Xie RY, Dusetti N, Iovanna J, Habib N, Peng L, Lee LTO, “Small activating RNA modulation of the G protein-coupled receptor for cancer treatment”, Adv. Sci. 2022, 2200562.

3.    Chen J, Ellert-Miklaszewska A, Garofalo S, Dey AK, Tang J, Jiang Y, Clément F, Marche PN, Liu X, Kaminska B, Santoni A, Limatola C, Rossi J, Zhou J, Peng L, “Synthesis and use of an amphiphilic dendrimer for siRNA delivery into primary immune cells”, Nat. Protoc. 2021, 16, 327.

4.    Lyu Z, Ding L, Tintaru A, Peng L, “Self-assembling supramolecular dendrimers for biomedical applications: lessons learned from poly(amido)amine dendrimers”, Acc. Chem. Res. 2020, 53, 2936.

5.    Garrigue P, Tang J, Ding L, Bouhlel A, Tintaru A, Laurini E, Huang Y, Lyu Z, Zhang M, Fernandez S, Balasse L, Lan W, Mas E, Marson D, Weng Y, Liu X, Giorgio S, Iovanna J, Pricl S, Guillet B, Peng L, Self-assembling supramolecular dendrimer nanosystem for PET imaging of tumors”, Proc. Natl. Acad. Sci. USA, 2018, 115, 11454

6.    Dong Y, Yu T, Ding L, Laurini E, Huang Y, Zhang M, Weng Y, Lin S, Chen P, Marson D, Jiang Y, Giorgio S, Pricl S, Liu X, Rocchi P, Peng L, “A dual targeting dendrimer-mediated siRNA delivery system for effective gene silencing in cancer therapy”, J. Am. Chem. Soc. 2018, 140, 16264.

7.    Liu X, Wang Y, Chen C, Tintaru A, Cao Y, Liu J, Ziarelli F, Tang J, Guo H, Rosas R, Giorgio S, Charles L, Rocchi P, Peng L, “A fluorinated bola-amphiphilic dendrimer for on-demand delivery of siRNA via specific response to reactive oxygen species”, Adv. Funct. Mater. 2016, 26, 8594.

8.    Wei T, Chen C, Liu J, Liu C, Posocco P, Liu X, Cheng Q, Huo S, Liang Z, Fermeglia M, Pricl S, Liang XJ, Rocchi P, Peng L, “Anticancer drug nanomicelles formed by self-assembling amphiphilic dendrimer to combat cancer drug resistance”, Proc. Natl. Acad. Sci. USA, 2015, 112, 2978.

9.    Liu X, Zhou J, Yu T, Chen C, Cheng Q, Sengupta K, Huang Y, Li H, Liu C, Wang Y, Posocco P, Wang M, Cui Q, Giorgio S, Fermeglia M, Qu F, Pricl S, Shi Y, Liang Z, Rocchi P, Rossi JJ, Peng L, “Adaptive amphiphilic dendrimer based nanoassemblies as robust and versatile siRNA delivery systems”, Angew. Chem. Int. Ed. 2014, 53, 11822.

10. Yu T, Liu X, Bolcato-Bellemin A-L, Wang Y, Liu C, Erbacher P, Qu F, Rocchi P, Behr J-P, Peng L, "An amphiphilic dendrimer for effective siRNA delivery and gene silencing in vitro and in vivo", Angew. Chem. Int. Ed. 2012, 51, 8478.

Publications

2022

Amphiphilic Dendrimer Vectors for RNA Delivery: State-of-the-Art and Future Perspective

Jiaxuan Chen, Dandan Zhu, Xiaoxuan Liu, Ling Peng

Accounts of Materials Research (2022)10.1021/accountsmr.1c00272

Dynamic self-assembling supramolecular dendrimer nanosystems as potent antibacterial candidates against drug-resistant bacteria and biofilms

Dinesh Dhumal, Bar Maron, Einav Malach, Zhenbin Lyu, Ling Ding, Domenico Marson, Erik Laurini, Aura Tintaru, Brigino Ralahy, Suzanne Giorgio, Sabrina Pricl, Zvi Hayouka, Ling Peng

Nanoscale (2022)10.1039/d2nr02305a

Thermostable ionizable lipid-like nanoparticle (iLAND) for RNAi treatment of hyperlipidemia

Bo Hu, Bo Li, Kun Li, Yuanyuan Liu, Chunhui Li, Lulu Zheng, Mengjie Zhang, Tongren Yang, Shuai Guo, Xiyu Dong, Tian Zhang, Qing Liu, Abid Hussain, Yuhua Weng, Ling Peng, Yongxiang Zhao, Xing-Jie Liang, Yuanyu Huang

Science Advances 8 (2022)10.1126/sciadv.abm1418

Solid-phase dendrimer synthesis: a promising approach to transform dendrimer construction

Ya-Ting Huang, C.-L Kao, A Selvaraj, Ling Peng

Materials Today Chemistry (2022)10.1016/j.mtchem.2022.101285

A biodegradable amphiphilic poly(aminoester) dendrimer for safe and effective siRNA delivery

Chi Ma, Dandan Zhu, Wenyi Lin, Ying Li, Yuanzheng Huang, Huiling Zhu, Mengyun Ye, Yang Wang, Ling Peng, Xiaoxuan Liu

Chemical Communications (2022)10.1039/D1CC06655B

Small Activating RNA Modulation of the G Protein‐Coupled Receptor for Cancer Treatment

Yunfang Xiong, Ran Ke, Qingyu Zhang, Wenjun Lan, Wanjun Yuan, Karol Nga Ieng Chan, Tom Roussel, Yifan Jiang, Jing Wu, Shuai Liu, Alice Sze Tsai Wong, Joong Sup Shim, Xuanjun Zhang, Ruiyu Xie, Nelson Dusetti, Juan Iovanna, Nagy Habib, Ling Peng, Leo Tsz On Lee

Advanced Science 2200562 (2022)10.1002/advs.202200562

Bola‐Amphiphilic Glycodendrimers: New Carbohydrate Mimicking Scaffolds to Target Carbohydrate‐Binding Proteins

Wenzheng Zhang, Dinesh Dhumal, Xiaolei Zhu, Brigino Ralahy, Aleksandra Ellert-Miklaszewska, Jing Wu, Erik Laurini, Yi-Wen W Yao, Chai-Lin L Kao, Juan L Iovanna, Sabrina Pricl, Bozena Kaminska, Yi Xia, Ling Peng

Chemistry - A European Journal (2022)10.1002/chem.202201400

2021

Synthesis and use of an amphiphilic dendrimer for siRNA delivery into primary immune cells

Jiaxuan Chen, Aleksandra Ellert-Miklaszewska, Stefano Garofalo, Arindam K Dey, Jingjie Tang, Yifan Jiang, Flora Clément, Patrice N. Marche, Xiaoxuan Liu, Bozena Kaminska, Angela Santoni, Cristina Limatola, John Rossi, Jiehua Zhou, Ling Peng

Nature Protocols (2021)10.1038/s41596-020-00418-9

A self-assembling prodrug nanosystem to enhance metabolic stability and anticancer activity of gemcitabine

Mei Cong, Guangling Xu, Shaoyou Yang, Jing Zhang, Wenzheng Zhang, Dinesh Dhumal, Erik Laurini, Kaiyue Zhang, Yi Xia, Sabrina Pricl, Ling Peng, Weidong Zhao

Chinese Chemical Letters (2021)10.1016/j.cclet.2021.11.083

An ionizable supramolecular dendrimer nanosystem for effective siRNA delivery with a favorable safety profile

Dinesh Dhumal, Wenjun Lan, Ling Ding, Yifan Jiang, Zhenbin Lyu, Erik Laurini, Domenico Marson, Aura Tintaru, Nelson Dusetti, Suzanne Giorgio, Juan Lucio Iovanna, Sabrina Pricl, Ling Peng

Nano Research (2021)10.1007/s12274-020-3216-8

NUPR1 inhibitor ZZW-115 induces ferroptosis in a mitochondria-dependent manner

Can Huang, Patricia Santofimia-Castaño, Xi Liu, Yi Xia, Ling Peng, Célia Gotorbe, Jose Luis Neira, Daolin Tang, Jacques Pouyssegur, Juan Iovanna

Cell Death Discovery 7:269 (2021)10.1038/s41420-021-00662-2

Dendrimeric Nanosystem Consistently Circumvents Heterogeneous Drug Response and Resistance in Pancreatic Cancer

Juan Liu, Chao Chen, Tuo Wei, Odile Gayet, Céline Loncle, Laurence Borge, Nelson Dusetti, Xiaowei Ma, Domenico Marson, Erik Laurini, Sabrina Pricl, Zhongwei Gu, Juan Iovanna, Ling Peng, Xing‐jie Liang

Energy Exploration and Exploitation 1:21-34 (2021)10.1002/EXP.20210003

Design of Inhibitors of the Intrinsically Disordered Protein NUPR1: Balance between Drug Affinity and Target Function

Bruno Rizzuti, Wenjun Lan, Patricia Santofimia-Castaño, Zhengwei Zhou, Adrián Velázquez-Campoy, Olga Abián, Ling Peng, José Neira, Yi Xia, Juan Iovanna

Biomolecules 11:1453 (2021)10.3390/biom11101453

2020

A self-assembling amphiphilic dendrimer nanotracer for SPECT imaging

Ling Ding, Zhenbin Lyu, Aura Tintaru, Erik Laurini, Domenico Marson, Beatrice Louis, Ahlem Bouhlel, Laure Balasse, Samantha Fernandez, Philippe Garrigue, Eric Mas, Suzanne Giorgio, Sabrina Pricl, Benjamin Guillet, Ling Peng

Chemical Communications 56:301-304 (2020)10.1039/c9cc07750b

Surface Charge of Supramolecular Nanosystems for In Vivo Biodistribution: A MicroSPECT/CT Imaging Study

Ling Ding, Zhenbin Lyu, Beatrice Louis, Aura Tintaru, Erik Laurini, Domenico Marson, Mengjie Zhang, Wanxuan Shao, Yifan Jiang, Ahlem Bouhlel, Laure Balasse, Philippe Garrigue, Eric Mas, Suzanne Giorgio, Juan Iovanna, Yuanyu Huang, Sabrina Pricl, Benjamin Guillet, Ling Peng

Small 16:301-304 (2020)10.1002/smll.202003290

Natural killer cells modulate motor neuron-immune cell cross talk in models of Amyotrophic Lateral Sclerosis

Stefano Garofalo, Germana Cocozza, Alessandra Porzia, Maurizio Inghilleri, Marcello Raspa, Ferdinando Scavizzi, Eleonora Aronica, Giovanni Bernardini, Ling Peng, Richard Ransohoff, Angela Santoni, Cristina Limatola

Nature Communications 11:1773 (2020)10.1038/s41467-020-15644-8

Therapeutic siRNA: state of the art

Bo Hu, Liping Zhong, Yuhua Weng, Ling Peng, Yuanyu Huang, Yongxiang Zhao, Xing-Jie Liang

Signal Transduction and Targeted Therapy 5 (2020)10.1038/s41392-020-0207-x

Liver Activation of Hepatocellular Nuclear Factor-4α by Small Activating RNA Rescues Dyslipidemia and Improves Metabolic Profile

Kai-Wen Huang, Vikash Reebye, Katherine Czysz, Simona Ciriello, Stephanie Dorman, Isabella Reccia, Hong-Shiee Lai, Ling Peng, Nikos Kostomitsopoulos, Joanna Nicholls, Robert S Habib, Donald A Tomalia, Pål Sætrom, Edmund Wilkes, Pedro Cutillas, John J Rossi, Nagy A Habib

Molecular Therapy - Nucleic Acids 19:361-370 (2020)10.1016/j.omtn.2019.10.044

ZZW-115–dependent inhibition of NUPR1 nuclear translocation sensitizes cancer cells to genotoxic agents

Wenjun Lan, Patricia Santofimia-Castaño, Mirna Swayden, Yi Xia, Zhengwei Zhou, Stephane Audebert, Luc Camoin, Can Huang, Ling Peng, Ana Jiménez-Alesanco, Adrián Velázquez-Campoy, Olga Abián, Gwen Lomberk, Raul Urrutia, Bruno Rizzuti, Vincent Geli, Philippe Soubeyran, José L Neira, Juan Iovanna

JCI Insight 5:e138117 (2020)10.1172/jci.insight.138117

Targeting NUPR1 with the small compound ZZW-115 is an efficient strategy to treat hepatocellular carcinoma

Wenjun Lan, Patricia Santofimia-Castaño, Yi Xia, Zhengwei Zhou, Can Huang, Nicolas Fraunhoffer, Dolores Barea, Melchiore Cervello, Lydia Giannitrapani, Giuseppe Montalto, Ling Peng, Juan Iovanna

Cancer Letters 486:8-17 (2020)10.1016/j.canlet.2020.04.024

Novel Aryltriazole Acyclic C-Azanucleosides as Anticancer Candidates

Yanhua Zhang, Yun Lin, Qianqian Hou, Xi Liu, Sabrina Pricl, Ling Peng, Yi Xia

Organic & Biomolecular Chemistry (2020)10.1039/d0ob02164d

Novel triazole nucleoside analogues promote anticancer activity via both apoptosis and autophagy

Yanhua Zhang, Xi Liu, Yun Lin, Baoping Lian, Wenjun Lan, Juan L Iovanna, Xiaoxuan Liu, Ling Peng, Yi Xia

Chemical Communications 56:10014-10017 (2020)10.1039/d0cc04660d

2019

Efficient and innocuous delivery of small interfering RNA to microglia using an amphiphilic dendrimer nanovector

Aleksandra Ellert-Miklaszewska, Natalia Ochocka, Marta Maleszewska, Ling Ding, Erik Laurini, Yifan Jiang, Adria-Jaume Roura, Suzanne Giorgio, Bartlomiej Gielniewski, Sabrina Pricl, Ling Peng, Bozena Kaminska

Nanomedicine 14:2441-2458 (2019)10.2217/nnm-2019-0176

Poly(amidoamine) dendrimers: covalent and supramolecular synthesis

Z. Lyu, L. Ding, A.Y.T. Huang, L. Kao, Ling Peng

Materials Today Chemistry 13:34-48 (2019)10.1016/j.mtchem.2019.04.004

Targeting the Stress-Induced Protein NUPR1 to Treat Pancreatic Adenocarcinoma

Patricia Santofimia-Castaño, Yi Xia, Ling Peng, Adrián Velázquez-Campoy, Olga Abián, Wenjun Lan, Gwen Lomberk, Raul Urrutia, Bruno Rizzuti, Philippe Soubeyran, José Luis Neira, Juan Iovanna

Cells 8:1453 (2019)10.3390/cells8111453

Designing and repurposing drugs to target intrinsically disordered proteins for cancer treatment: using NUPR1 as a paradigm

Patricia Santofimia-Castaño, Bruno Rizzuti, Yi Xia, Olga Abián, Ling Peng, Adrián Velázquez-Campoy, Juan Iovanna, José L Neira

Molecular & Cellular Oncology 1-3 (2019)10.1080/23723556.2019.1612678

Ligand-based design identifies a potent NUPR1 inhibitor exerting anticancer activity via necroptosis

Patricia Santofimia-Castaño, Yi Xia, Wenjun Lan, Zhengwei Zhou, Can Huang, Ling Peng, Philippe Soubeyran, Adrián Velázquez-Campoy, Olga Abián, Bruno Rizzuti, José L Neira, Juan Iovanna

Journal of Clinical Investigation 129:2500-2513 (2019)10.1172/jci127223

Targeting intrinsically disordered proteins involved in cancer

Patricia Santofimia-Castaño, Bruno Rizzuti, Yi Xia, Olga Abián, Ling Peng, Adrián Velázquez-Campoy, José L Neira, Juan L. Iovanna

Cellular and Molecular Life Sciences (2019)10.1007/s00018-019-03347-3

Flavonoid–alkylphospholipid conjugates elicit dual inhibition of cancer cell growth and lipid accumulation

Zhengwei Zhou, Biyao Luo, Xi Liu, Mimi Chen, Wenjun Lan, Juan L Iovanna, Ling Peng, Yi Xia

Chemical Communications 55:8919-8922 (2019)10.1039/c9cc04084f