Ling Peng
TPR1 - 4 étage
DR1
chercheur
G4.17

dendrimers, drug delivery, nanobiotechnology, nanomedicine
1. Intelligent functional biomaterials for drug deliery based on dendrimer nanotechnology
2. Molecular probes and chemical biology
3. Drug discovery based on triazole nucleoside chemistry
Functional and intelligent biomaterials based on dendrimer nanotechnology: In order to treat various life-threatening diseases such as cancer, infection and neurodegenerative dementia, it is essential to develop efficient systems which enable precise diagnosis and effective treatment of diseases by delivering the right agents at the right sites with the right doses and timing. Dendrimers are the ideal delivery systems by virtue of their uniquely well-defined and precisely controlled structure with multivalent cooperativity confined within a nanosized volume. We are developing functional biocompatible dendrimer materials for bioimaging-based diagnosis, cancer treatment and gene therapy.
Molecular probes and chemical biology: Molecular probes are useful tools to study and understand biological events. We have designed and synthesized various molecular probes of phospholipids and of 2-oxoglutarate, an important intermediate of the Kreb’s cycle, with a view to studying biomembranes and the signaling roles and pathways of Kreb’s cycle intermediates in nitrogen fixation and cancer development.
Drug discovery based on triazole nucleoside chemistry: Nucleoside mimics are of great importance in the search for antiviral, anticancer and antibacterial drug candidates. One noteworthy example is ribavirin, the first synthetic triazole nucleoside showing antiviral activity against a broad spectrum of viruses. We have developed novel triazole nucleoside derivatives using modern green chemistry. Some of the lead compounds have shown excellent potency against drug-resistant cancers with novel modes of action such as targeting the heat shock response pathway, inducing autophagy and eliciting an immunomodulation effect etc.
Dr. Ling Peng is a research director at the French National Scientific Research Center (CNRS) in France. She carried her undergraduate study in polymer chemistry with Prof. Chen Rongshi at Nanjing University in China, her PhD program in organic chemistry with Prof. Albert Eschenmoser at Swiss Federal Institute of Technology in Zurich, Switzerland, and her postdoctoral research in Pharmacy with Prof. Maurice Goeldner at Louis Pasteur University of Strasbourg in France. She was recruited as a research scientist in CNRS in 1997, promoted as a CNRS research director in 2008, and then 1st class Research Director in 2015.
Dr. Ling PENG has been working actively at the interface of chemistry and biology, and in particular, developing functional dendrimers for biomedical applications, molecular probes for exploring biological events and nucleoside analogues for drug discovery. She has established bio-inspired structurally flexible dendrimers for nucleic acid delivery. Recently, she has inaugurated the concept of self-assembling supramolecular dendrimers, and applied this concept to deliver various anticancer drugs, nucleic acid therapeutics and imaging agents for cancer treatment and imaging. Her research team has been labelled by La Ligue contre Le Cancer in France since 2016.
Dr. Ling PENG was awarded with the Prize of Dr & Mme Henri Labbé of the French Academy of Sciences in 2017 and the Distinguished Member of French Chemical Society in 2020.
Selected Publications:
1. Chen J, Zhu D, Liu X, Peng L, “Amphiphilic dendrimer vectors for RNA delivery: state-of-the-art and future perspective”, Acc. Mater. Res. 2022, 3, 5, 484-497.
2. Xiong Y, Ke R, Zhang Q, Lan W, Yuan W, Chan KNI, Roussel T, Jiang Y, Wu J, Liu S, Wong AST, Shim JS, Zhang X, Xie RY, Dusetti N, Iovanna J, Habib N, Peng L, Lee LTO, “Small activating RNA modulation of the G protein-coupled receptor for cancer treatment”, Adv. Sci. 2022, 2200562.
3. Chen J, Ellert-Miklaszewska A, Garofalo S, Dey AK, Tang J, Jiang Y, Clément F, Marche PN, Liu X, Kaminska B, Santoni A, Limatola C, Rossi J, Zhou J, Peng L, “Synthesis and use of an amphiphilic dendrimer for siRNA delivery into primary immune cells”, Nat. Protoc. 2021, 16, 327.
4. Lyu Z, Ding L, Tintaru A, Peng L, “Self-assembling supramolecular dendrimers for biomedical applications: lessons learned from poly(amido)amine dendrimers”, Acc. Chem. Res. 2020, 53, 2936.
5. Garrigue P, Tang J, Ding L, Bouhlel A, Tintaru A, Laurini E, Huang Y, Lyu Z, Zhang M, Fernandez S, Balasse L, Lan W, Mas E, Marson D, Weng Y, Liu X, Giorgio S, Iovanna J, Pricl S, Guillet B, Peng L, “Self-assembling supramolecular dendrimer nanosystem for PET imaging of tumors”, Proc. Natl. Acad. Sci. USA, 2018, 115, 11454
6. Dong Y, Yu T, Ding L, Laurini E, Huang Y, Zhang M, Weng Y, Lin S, Chen P, Marson D, Jiang Y, Giorgio S, Pricl S, Liu X, Rocchi P, Peng L, “A dual targeting dendrimer-mediated siRNA delivery system for effective gene silencing in cancer therapy”, J. Am. Chem. Soc. 2018, 140, 16264.
7. Liu X, Wang Y, Chen C, Tintaru A, Cao Y, Liu J, Ziarelli F, Tang J, Guo H, Rosas R, Giorgio S, Charles L, Rocchi P, Peng L, “A fluorinated bola-amphiphilic dendrimer for on-demand delivery of siRNA via specific response to reactive oxygen species”, Adv. Funct. Mater. 2016, 26, 8594.
8. Wei T, Chen C, Liu J, Liu C, Posocco P, Liu X, Cheng Q, Huo S, Liang Z, Fermeglia M, Pricl S, Liang XJ, Rocchi P, Peng L, “Anticancer drug nanomicelles formed by self-assembling amphiphilic dendrimer to combat cancer drug resistance”, Proc. Natl. Acad. Sci. USA, 2015, 112, 2978.
9. Liu X, Zhou J, Yu T, Chen C, Cheng Q, Sengupta K, Huang Y, Li H, Liu C, Wang Y, Posocco P, Wang M, Cui Q, Giorgio S, Fermeglia M, Qu F, Pricl S, Shi Y, Liang Z, Rocchi P, Rossi JJ, Peng L, “Adaptive amphiphilic dendrimer based nanoassemblies as robust and versatile siRNA delivery systems”, Angew. Chem. Int. Ed. 2014, 53, 11822.
10. Yu T, Liu X, Bolcato-Bellemin A-L, Wang Y, Liu C, Erbacher P, Qu F, Rocchi P, Behr J-P, Peng L, "An amphiphilic dendrimer for effective siRNA delivery and gene silencing in vitro and in vivo", Angew. Chem. Int. Ed. 2012, 51, 8478.
2023
Cargo-selective and adaptive delivery of nucleic acid therapeutics by bola-amphiphilic dendrimers
Jiaxuan Chen, Dandan Zhu, Baoping Lian, Kangjie Shi, Peng Chen, Ying Li, Wenyi Lin, Ling Ding, Qiulin Long, Yang Wang, Erik Laurini, Wenjun Lan, Yun Li, Aura Tintaru, Caoyun Ju, Can Zhang, Sabrina Pricl, Juan Iovanna, Xiaoxuan Liu, Ling Peng
Proceedings of the National Academy of Sciences of the United States of America 120:e2220787120 (2023)10.1073/pnas.2220787120
Amphiphilic dendrimers against antibiotic resistance: light at the end of the tunnel?
Christina Galanakou, Dinesh Dhumal, Ling Peng
Biomaterials Science (2023)10.1039/D2BM01878K
Dendrimer nanosystems for adaptive tumor-assisted drug delivery via extracellular vesicle hijacking
Yifan Jiang, Zhenbin Lyu, Brigino Ralahy, Juan Liu, Tom Roussel, Ling Ding, Jingjie Tang, Artemis Kosta, Suzanne Giorgio, Richard Tomasini, Xing-Jie Liang, Nelson Dusetti, Juan Iovanna, Ling Peng
Proceedings of the National Academy of Sciences of the United States of America 120 (2023)10.1073/pnas.2215308120
Amphiphilic Dendrimer Doping Enhanced pH-Sensitivity of Liposomal Vesicle for Effective Co-delivery Toward Synergistic Ferroptosis-Apoptosis Therapy of Hepatocellular Carcinoma
Yanhong Su, Zhao Zhang, Leo Tsz, Ling Peng, Ligong Lu, Xu He, Xuanjun Zhang
Advanced Healthcare Materials 12:2202663 (2023)10.1002/adhm.202202663
A PD‐L1 Antibody‐Conjugated PAMAM Dendrimer Nanosystem for Simultaneously Inhibiting Glycolysis and Promoting Immune Response in Fighting Breast Cancer
Peng Zhang, Zhi Li, Weiling Cao, Jingjie Tang, Yi Xia, Ling Peng, Jing Ma
Advanced Materials (2023)10.1002/adma.202305215
2022
Amphiphilic Dendrimer Vectors for RNA Delivery: State-of-the-Art and Future Perspective
Jiaxuan Chen, Dandan Zhu, Xiaoxuan Liu, Ling Peng
Accounts of Materials Research (2022)10.1021/accountsmr.1c00272
Dynamic self-assembling supramolecular dendrimer nanosystems as potent antibacterial candidates against drug-resistant bacteria and biofilms
Dinesh Dhumal, Bar Maron, Einav Malach, Zhenbin Lyu, Ling Ding, Domenico Marson, Erik Laurini, Aura Tintaru, Brigino Ralahy, Suzanne Giorgio, Sabrina Pricl, Zvi Hayouka, Ling Peng
Nanoscale (2022)10.1039/d2nr02305a
Thermostable ionizable lipid-like nanoparticle (iLAND) for RNAi treatment of hyperlipidemia
Bo Hu, Bo Li, Kun Li, Yuanyuan Liu, Chunhui Li, Lulu Zheng, Mengjie Zhang, Tongren Yang, Shuai Guo, Xiyu Dong, Tian Zhang, Qing Liu, Abid Hussain, Yuhua Weng, Ling Peng, Yongxiang Zhao, Xing-Jie Liang, Yuanyu Huang
Science Advances 8 (2022)10.1126/sciadv.abm1418
Solid-phase dendrimer synthesis: a promising approach to transform dendrimer construction
Ya-Ting Huang, C.-L Kao, A Selvaraj, Ling Peng
Materials Today Chemistry (2022)10.1016/j.mtchem.2022.101285
A biodegradable amphiphilic poly(aminoester) dendrimer for safe and effective siRNA delivery
Chi Ma, Dandan Zhu, Wenyi Lin, Ying Li, Yuanzheng Huang, Huiling Zhu, Mengyun Ye, Yang Wang, Ling Peng, Xiaoxuan Liu
Chemical Communications (2022)10.1039/D1CC06655B
NUPR1 protects against hyperPARylation-dependent cell death
Patricia Santofimia-Castano, Can Huang, Xi Liu, Yi Xia, Stephane Audebert, Luc Camoin, Ling Peng, Gwen Lomberk, Raul Urrutia, Philippe Soubeyran, Jose Luis Neira, Juan Iovanna
Communications Biology 5 (2022)10.1038/s42003-022-03705-1
Small Activating RNA Modulation of the G Protein‐Coupled Receptor for Cancer Treatment
Yunfang Xiong, Ran Ke, Qingyu Zhang, Wenjun Lan, Wanjun Yuan, Karol Nga Ieng Chan, Tom Roussel, Yifan Jiang, Jing Wu, Shuai Liu, Alice Sze Tsai Wong, Joong Sup Shim, Xuanjun Zhang, Ruiyu Xie, Nelson Dusetti, Juan Iovanna, Nagy Habib, Ling Peng, Leo Tsz On Lee
Advanced Science 2200562 (2022)10.1002/advs.202200562
Bola‐Amphiphilic Glycodendrimers: New Carbohydrate Mimicking Scaffolds to Target Carbohydrate‐Binding Proteins
Wenzheng Zhang, Dinesh Dhumal, Xiaolei Zhu, Brigino Ralahy, Aleksandra Ellert-Miklaszewska, Jing Wu, Erik Laurini, Yi-Wen W Yao, Chai-Lin L Kao, Juan L Iovanna, Sabrina Pricl, Bozena Kaminska, Yi Xia, Ling Peng
Chemistry - A European Journal (2022)10.1002/chem.202201400
2021
Synthesis and use of an amphiphilic dendrimer for siRNA delivery into primary immune cells
Jiaxuan Chen, Aleksandra Ellert-Miklaszewska, Stefano Garofalo, Arindam K Dey, Jingjie Tang, Yifan Jiang, Flora Clément, Patrice N. Marche, Xiaoxuan Liu, Bozena Kaminska, Angela Santoni, Cristina Limatola, John Rossi, Jiehua Zhou, Ling Peng
Nature Protocols (2021)10.1038/s41596-020-00418-9
A self-assembling prodrug nanosystem to enhance metabolic stability and anticancer activity of gemcitabine
Mei Cong, Guangling Xu, Shaoyou Yang, Jing Zhang, Wenzheng Zhang, Dinesh Dhumal, Erik Laurini, Kaiyue Zhang, Yi Xia, Sabrina Pricl, Ling Peng, Weidong Zhao
Chinese Chemical Letters (2021)10.1016/j.cclet.2021.11.083
An ionizable supramolecular dendrimer nanosystem for effective siRNA delivery with a favorable safety profile
Dinesh Dhumal, Wenjun Lan, Ling Ding, Yifan Jiang, Zhenbin Lyu, Erik Laurini, Domenico Marson, Aura Tintaru, Nelson Dusetti, Suzanne Giorgio, Juan Lucio Iovanna, Sabrina Pricl, Ling Peng
Nano Research (2021)10.1007/s12274-020-3216-8
NUPR1 inhibitor ZZW-115 induces ferroptosis in a mitochondria-dependent manner
Can Huang, Patricia Santofimia-Castaño, Xi Liu, Yi Xia, Ling Peng, Célia Gotorbe, Jose Luis Neira, Daolin Tang, Jacques Pouyssegur, Juan Iovanna
Cell Death Discovery 7:269 (2021)10.1038/s41420-021-00662-2
Dendrimeric Nanosystem Consistently Circumvents Heterogeneous Drug Response and Resistance in Pancreatic Cancer
Juan Liu, Chao Chen, Tuo Wei, Odile Gayet, Céline Loncle, Laurence Borge, Nelson Dusetti, Xiaowei Ma, Domenico Marson, Erik Laurini, Sabrina Pricl, Zhongwei Gu, Juan Iovanna, Ling Peng, Xing‐jie Liang
Energy Exploration and Exploitation 1:21-34 (2021)10.1002/EXP.20210003
Design of Inhibitors of the Intrinsically Disordered Protein NUPR1: Balance between Drug Affinity and Target Function
Bruno Rizzuti, Wenjun Lan, Patricia Santofimia-Castaño, Zhengwei Zhou, Adrián Velázquez-Campoy, Olga Abián, Ling Peng, José Neira, Yi Xia, Juan Iovanna
Biomolecules 11:1453 (2021)10.3390/biom11101453
2020
A self-assembling amphiphilic dendrimer nanotracer for SPECT imaging
Ling Ding, Zhenbin Lyu, Aura Tintaru, Erik Laurini, Domenico Marson, Beatrice Louis, Ahlem Bouhlel, Laure Balasse, Samantha Fernandez, Philippe Garrigue, Eric Mas, Suzanne Giorgio, Sabrina Pricl, Benjamin Guillet, Ling Peng
Chemical Communications 56:301-304 (2020)10.1039/c9cc07750b
Surface Charge of Supramolecular Nanosystems for In Vivo Biodistribution: A MicroSPECT/CT Imaging Study
Ling Ding, Zhenbin Lyu, Beatrice Louis, Aura Tintaru, Erik Laurini, Domenico Marson, Mengjie Zhang, Wanxuan Shao, Yifan Jiang, Ahlem Bouhlel, Laure Balasse, Philippe Garrigue, Eric Mas, Suzanne Giorgio, Juan Iovanna, Yuanyu Huang, Sabrina Pricl, Benjamin Guillet, Ling Peng
Small 16:301-304 (2020)10.1002/smll.202003290
Natural killer cells modulate motor neuron-immune cell cross talk in models of Amyotrophic Lateral Sclerosis
Stefano Garofalo, Germana Cocozza, Alessandra Porzia, Maurizio Inghilleri, Marcello Raspa, Ferdinando Scavizzi, Eleonora Aronica, Giovanni Bernardini, Ling Peng, Richard Ransohoff, Angela Santoni, Cristina Limatola
Nature Communications 11:1773 (2020)10.1038/s41467-020-15644-8
Therapeutic siRNA: state of the art
Bo Hu, Liping Zhong, Yuhua Weng, Ling Peng, Yuanyu Huang, Yongxiang Zhao, Xing-Jie Liang
Signal Transduction and Targeted Therapy 5 (2020)10.1038/s41392-020-0207-x
Liver Activation of Hepatocellular Nuclear Factor-4α by Small Activating RNA Rescues Dyslipidemia and Improves Metabolic Profile
Kai-Wen Huang, Vikash Reebye, Katherine Czysz, Simona Ciriello, Stephanie Dorman, Isabella Reccia, Hong-Shiee Lai, Ling Peng, Nikos Kostomitsopoulos, Joanna Nicholls, Robert S Habib, Donald A Tomalia, Pål Sætrom, Edmund Wilkes, Pedro Cutillas, John J Rossi, Nagy A Habib
Molecular Therapy - Nucleic Acids 19:361-370 (2020)10.1016/j.omtn.2019.10.044
ZZW-115–dependent inhibition of NUPR1 nuclear translocation sensitizes cancer cells to genotoxic agents
Wenjun Lan, Patricia Santofimia-Castaño, Mirna Swayden, Yi Xia, Zhengwei Zhou, Stephane Audebert, Luc Camoin, Can Huang, Ling Peng, Ana Jiménez-Alesanco, Adrián Velázquez-Campoy, Olga Abián, Gwen Lomberk, Raul Urrutia, Bruno Rizzuti, Vincent Geli, Philippe Soubeyran, José L Neira, Juan Iovanna
JCI Insight 5:e138117 (2020)10.1172/jci.insight.138117
Targeting NUPR1 with the small compound ZZW-115 is an efficient strategy to treat hepatocellular carcinoma
Wenjun Lan, Patricia Santofimia-Castaño, Yi Xia, Zhengwei Zhou, Can Huang, Nicolas Fraunhoffer, Dolores Barea, Melchiore Cervello, Lydia Giannitrapani, Giuseppe Montalto, Ling Peng, Juan Iovanna
Cancer Letters 486:8-17 (2020)10.1016/j.canlet.2020.04.024
Self-assembling supramolecular dendrimers for biomedical applications: lessons learned from poly(amidoamine) dendrimers
Zhenbin Lyu, Ling Ding, Aura Tintaru, Ling Peng
Accounts of Chemical Research (2020)10.1021/acs.accounts.0c00589
Novel Aryltriazole Acyclic C-Azanucleosides as Anticancer Candidates
Yanhua Zhang, Yun Lin, Qianqian Hou, Xi Liu, Sabrina Pricl, Ling Peng, Yi Xia
Organic & Biomolecular Chemistry (2020)10.1039/d0ob02164d
Novel triazole nucleoside analogues promote anticancer activity via both apoptosis and autophagy
Yanhua Zhang, Xi Liu, Yun Lin, Baoping Lian, Wenjun Lan, Juan L Iovanna, Xiaoxuan Liu, Ling Peng, Yi Xia
Chemical Communications 56:10014-10017 (2020)10.1039/d0cc04660d
2019
Designing and repurposing drugs to target intrinsically disordered proteins for cancer treatment: using NUPR1 as a paradigm
Patricia Santofimia-Castaño, Bruno Rizzuti, Yi Xia, Olga Abián, Ling Peng, Adrián Velázquez-Campoy, Juan Iovanna, José L Neira
Molecular & Cellular Oncology 1-3 (2019)10.1080/23723556.2019.1612678