Ling Peng

Activity

dendrimers, drug delivery, nanobiotechnology, nanomedicine

Thèmes

1.     Functional biomaterials for drug delivery based on dendrimer nanotechnology

2.     Molecular probes and chemical biology

3.     Drug discovery based on triazole nucleoside chemistry

Recherche

Functional biomaterials based on dendrimer nanotechnology: In order to treat various life-threatening diseases such as cancer, infection and neurodegenerative dementia, it is essential to develop efficient systems which enable precise diagnosis and effective treatment by delivering the right pharmaceutics at the right site with the right dose and timing. Dendrimers are the ideal precision materials for drug delivery by virtue of their uniquely well-defined and precisely controlled structure with multivalent cooperativity confined within a nanosized volume. We are developing functional biocompatible dendrimer materials for bioimaging-based diagnosis, cancer treatment and gene therapy based on self-assembling supramolecular chemistry.

Molecular probes and chemical biology: Molecular probes are useful tools to study and understand biological events. We have designed and synthesized various molecular probes of phospholipids and of 2-oxoglutarate, an important intermediate of the Kreb’s cycle, with a view to studying bio-membranes and the signaling roles and pathways of Kreb’s cycle intermediates in nitrogen fixation and cancer development.

Drug discovery based on triazole nucleoside chemistry: Nucleoside mimics are of great importance in the search for antiviral, anticancer and antibacterial drug candidates. One noteworthy example is ribavirin, the first synthetic triazole nucleoside showing antiviral activity against a broad spectrum of viruses. We have developed novel triazole nucleoside derivatives using modern green chemistry. Some of the lead compounds have shown excellent potency against drug-resistant cancers with novel modes of action such as targeting the heat shock response pathway, inducing autophagy and eliciting an immunomodulation effect etc.

Parcours

Dr. Ling Peng is a research director at the French National Scientific Research Center (CNRS) in France. She carried her undergraduate study in polymer chemistry with Prof. Chen Rongshi at Nanjing University in China, her PhD program in organic chemistry with Prof. Albert Eschenmoser at Swiss Federal Institute of Technology in Zurich, Switzerland, and her postdoctoral research in pharmacy with Prof. Maurice Goeldner at Louis Pasteur University of Strasbourg in France. She was recruited as a research scientist in CNRS in 1997, promoted as a CNRS research director in 2008, then the 1st class Research Director in 2015 and the exceptional class Research Director in 2023.

Dr. Ling PENG has been working actively at the interface of chemistry and biology, and in particular, developing functional dendrimers for biomedical applications, molecular probes for exploring biological events and nucleoside analogues for drug discovery. She has established bio-inspired structurally flexible dendrimers for nucleic acid delivery. Recently, she has inaugurated the concept of self-assembling supramolecular dendrimers, and applied this concept to deliver various anticancer drugs, nucleic acid therapeutics and imaging agents for cancer treatment and imaging. Her research team has been labelled by La Ligue contre Le Cancer in France since 2016.

Dr. Ling PENG is the Distinguished Member of the French Chemical Society since 2019. She was awarded with the Prize of Dr & Mme Henri Labbé of the French Academy of Sciences in 2017, the Grand Prize of the French Chemical Society SUD PACA and the Prize of André Collet of Supramolecualr Chemistry of French Chemical Society in 2024.

Selected Publications:

1.     Zhenbin Lyu, Brigino Ralahy, Teodora-Adriana Perles-Barbacaru, Ling Ding, Yifan Jiang, Baoping Lian, Tom Roussel, Xi Liu, Christina Galanakou, Erik Laurini, Aura Tintaru, Suzanne Giorgio, Sabrina Pricl, Xiaoxuan Liu, Juan Iovanna, Monique Bernard, Angèle Viola, Ling Peng, “Self-assembling dendrimer nanosystems for specific fluorine magnetic resonance imaging and effective theranostic treatment of tumors”, Proc. Natl. Acad. Sci. U.S.A. 2024, 121, e2322403121.

2.     Ling Ding, Zhenbin Lyu, Teodora-Adriana Perles-Barbacaru, Adela Ya-Ting Huang, Baoping Lian, Yifan Jiang, Tom Roussel, Christina Galanakou, Suzanne Giorgio, Chai-Lin Kao, Xiaoxuan Liu, Juan Iovanna, Monique Bernard, Angèle Viola, Ling Peng, “Modular self-assembling dendrimer nanosystems for magnetic resonance and multimodality imaging of tumors”, Adv. Mater. 2024, 36, 2308262.  DOI:10.1002/adma.202308262.

3.     Jiaxuan Chen, Dandan Zhu, Baoping Lian, Kangjie Shi, Peng Chen, Ying Li, Wenyi Lin, Ling Ding, Qiulin Long, Yang Wang, Erik Laurini, Wenjun Lan, Yun Li, Aura Tintaru, Caoyun Ju, Can Zhang, Sabrina Pricl, Juan Iovanna, Xiaoxuan Liu, Ling Peng, “Cargo-selective and adaptive delivery of nucleic acids by bola-amphiphilic dendrimers”, Proc. Natl. Acad. Sci. U.S.A. 2023, 120, e2220787120. DOI: 10.1073/pnas.2220787120.

4.     Yifan Jiang, Zhenbin Lyu, Brigino Ralahy, Juan Liu, Tom Roussel, Ling Ding, Jingjie Tang, Artemis Kosta, Suzanne Giorgio, Richard Tomasini, Xing-Jie Liang, Nelson Dusetti, Juan Iovanna, Ling Peng, “Dendrimer nanosystems for adaptive tumour-assisted drug delivery via extracellular vesicle hijacking”, Proc. Natl. Acad. Sci. U.S.A. 2023, 120, e2215308120. DOI: 10.1073/pnas.2215308120.

5.     Jiaxuan Chen, Dandan Zhu, Xiaoxuan Liu, Ling Peng, “Amphiphilic dendrimer vectors for RNA delivery: state-of-the-art and future perspective”, Acc. Mater. Res. 2022, 3, 484-497. DOI:10.1021/accountsmr.1c00272

6.     Jiaxuan Chen, Aleksandra Ellert-Miklaszewska, Stefano Garofalo, Arindam K Dey, Jingjie Tang, Yifan Jiang, Flora Clément, Patrice N Marche, Xiaoxuan Liu, Bozena Kaminska, Angela Santoni, Cristina Limatola, John Rossi, Jiehua Zhou, Ling Peng, “Synthesis and use of an amphiphilic dendrimer for siRNA delivery into primary immune cells”, Nat. Protoc. 2021, 16, 327–351. DOI: 10.1038/s41596-020-00418-9

7.     Zhenbin Lyu, Ling Ding, Aura Tintaru, Ling Peng, “Self-assembling supramolecular dendrimers for biomedical applications: lessons learned from poly(amido)amine dendrimers”, Acc. Chem. Res. 2020, 53, 2936-2946. DOI: 10.1021/acs.accounts.0c00589

8.     Philippe Garrigue, Jingjie Tang, Ling Ding, Ahlem Bouhlel, Aura Tintaru, Erik Laurini, Yuanyu Huang, Zhenbin Lyu, Mengjie Zhang, Samantha Fernandez, Laure Balasse, Wenjun Lan, Eric Mas, Domenico Marson, Yuhua Weng, Xiaoxuan Liu, Suzanne Giorgio, Juan Iovanna, Sabrina Pricl, Benjamin Guillet, Ling Peng, “Self-assembling supramolecular dendrimer nanosystem for PET imaging of tumors”, Proc. Natl. Acad. Sci. U.S.A. 2018, 115, 11454-11459. DOI: 10.1073/pnas.1812938115

9.     Yiwen Dong, Tianzhu Yu, Ling Ding, Erik Laurini, Yuanyu Huang, Mengjie Zhang, Yuhua Weng, Shuting Lin, Peng Chen, Domenico Marson, Yifan Jiang, Suzanne Giorgio, Sabrina Pricl, Xiaoxuan Liu, Palma Rocchi, Ling Peng, “A dual targeting dendrimer-mediated siRNA delivery system for effective gene silencing in cancer therapy”, J. Am. Chem. Soc. 2018, 140, 16264-16274. DOI: 10.1021/jacs.8b10021

10.  Xiaoxuan Liu, Yang Wang, Chao Chen, Aura Tintaru, Yu Cao, Juan Liu, Fabio Ziarelli, Jingjie Tang, Hongbo Guo, Roseline Rosas, Suzanne Giorgio, Laurence Charles, Palma Rocchi, Ling Peng, “A fluorinated bola-amphiphilic dendrimer for on-demand delivery of siRNA, via specific response to reactive oxygen species”, Adv. Funct. Mater. 2016, 26, 8594-8603. DOI: 10.1002/adfm.201604192

11.  Tuo Wei, Juan Liu, Chao Chen, Cheng Liu, Paola Posocco, Xiaoxuan Liu, Qiang Cheng, Shuaidong Huo, Zicai Liang, Maurizio Fermeglia, Sabrina Pricl, Xing-Jie Liang, Palma Rocchi, Ling Peng, “Anticancer drug nanomicelles formed by self-assembling amphiphilic dendrimer to combat cancer drug resistance”, Proc. Natl. Acad. Sci. U.S.A. 2015, 112, 2978–2983. DOI: 10.1073/pnas.1418494112.

12. Xiaoxuan Liu, Jiehua Zhou, Tianzhu Yu, Chao Chen, Qiang Cheng, Yuanyu Huang, Kheya Sengupta, Haitang Li, Cheng Liu, Yang Wang, Menghua Wang, Suzanne Giorgio, Fanqi Qu, Zicai Liang, Palma Rocchi, John J Rossi, Ling Peng, “Adaptive amphiphilic dendrimer based nanoassemblies as robust and versatile siRNA delivery systems”, Angew. Chem. Int. Ed. 2014, 53, 11822–11827. DOI: 10.1002/anie.201406764