Annie Viallat
TPR1 - 3 étage
DR1
chercheur
G.03.24
biological physics –Fluid and elasticity in cells - Membranes – cell rheology
Current Research Area : Active Matter - Biofluid Physics – Fluid and elasticity in living systems
Soft micro-shells, artificial capsules, liposomes, encapsulation.
Red blood cells dynamics in flow: Lift force – Cell Biomechanics –Sedimentation – fluid structure interaction
Blood cell Dynamics in the microvasculature: Microfluidics- red blood cells in submicron splenic slits - vasoocclusion in sickle cell anemia, blood cells adhesion and margination
Physics of the mucociliary transport: collective behaviour of bronchial cilia, flow patterns, coupling between ciliary activity and mucus transport
Soft micro-shells, micro-beads, liposomes, encapsulation
Viscous and Gelly giant vesicles – Standards for comet assays – Artificial vacuoles for living parasites
GUV and Red blood cells dynamics in flow
Lift force – Cell Biomechanics –Sedimentation -
Red and White Blood Cells Dynamics in biomimicking capillary networks
Microfluidics – Cell Rheology – Transport in the Vasculature
Artifical vacuoles for Leishmania
Severe asthma: physicial aspects of the mucociliary transport
Microrheology – cilia beats– application for severe asthma
Biography
Annie Viallat is engineer of Ecole Polytechnique (Paris, France). She received her PhD in Physics from the University of Grenoble (France) in 1987, working on polymer gels and NMR. After a postdoc on theory of conjugated polymers in the Materials Departments (UC Santa Barbara), she joined the Spectrométrie Physique lab (Grenoble) in 1989, studying polymer gels and heterogeneous polymer solutions. Her research moved to biological physics in 1999. From 2005 to 2015 she led a group in Marseille on the dynamics in microflows of vesicles and blood cells. Since 2016, she is the head of department ‘Physics and Engineering for Living Matter’ in CINaM (Marseille), working on active matter, microcirculation of red blood cells in disease and physics of the mucociliary clearance.
Positions
2016- Head of department at CINaM Physics and nano/micro engineering of living systems,
2007-2014 Director of the CNRS French Consortium ‘Physics from Cell to Tissue’
2005-2015 Group leader ‘biomimetics’, Adhesion & Inflammation lab., Marseille Biophysics-Biomechanics
1999-2002 Group Leader, Laboratoire Spectrométrie Physique, Grenoble, Polymers, Giant Lipid vesicles
1989-1999 Junior Research Scientist, Laboratoire Spectrométrie Physique, Grenoble
Academic degrees
1982 Engineer Ecole Polytechnique, Paris
1984 Engineer: Rural Eng., Water, Paris
1984 Master in Solid State Physics, Paris 7
Awards: PhD fellowship Rhône Poulenc (1985), Postdoc fellowship UCSB, Material Department (1988), PES CNRS 2010-2013,
Grants: 2002 IPMC Grenoble, 2003 Region RhôneAlpes, 2004 CPER RhôneAlpes, 2004 PIR microfluidique, 204 AC CNRS, 2004 IT2B, 2009 ANR, 2010 PACA region, 2010 C’Nano PACA, 2011 CNRS prise de risque, 2011 CAPES-COFECUB program, 2013 ANR, 2013 AMidex*
Management-expertise: ANR (France), NSF (USA), FET program (European Commission), Comité National (CNRS), CNU, AERES
2023
Transit Time Theory for a Droplet Passing through a Slit in Pressure-Driven Low Reynolds Number Flows
Spencer W Borbas, Kevin Shen, Catherine Ji, Annie Viallat, Emmanuèle Helfer, Zhangli Peng
Micromachines 14:2040 (2023)10.3390/mi14112040 
Classification of red cell dynamics with convolutional and recurrent neural networks: a sickle cell disease case study
Maxime Darrin, Ashwin Samudre, Maxime Sahun, Scott Atwell, Catherine Badens, Anne Charrier, Emmanuèle Helfer, Annie Viallat, Vincent Cohen-Addad, Sophie Giffard-Roisin
Scientific Reports 13:745 (2023)10.1038/s41598-023-27718-w
Enhanced cell viscosity: a new phenotype associated with lamin A/C alterations
Cécile Jebane, Alice-Anaïs Varlet, Marc Karnat, Lucero Hernandez- Cedillo, Amélie Lecchi, Frédéric Bedu, Camille Desgrouas, Corinne Vigouroux, Marie-Christine Vantyghem, Annie Viallat, Jean-François Rupprecht, Emmanuèle Helfer, Catherine Badens
iScience 26:107714 (2023)10.1016/j.isci.2023.107714
Physical mechanisms of red blood cell splenic filtration
Alexis Moreau, François Yaya, Huije Lu, Anagha Surendranath, Anne Charrier, Benoit Dehapiot, Emmanuèle Helfer, Annie Viallat, Zhangli Peng
Proceedings of the National Academy of Sciences of the United States of America (2023)10.1101/2023.01.10.523245
Analytical theory for a droplet squeezing through a circular pore in creeping flows under constant pressures
Zhengxin Tang, François Yaya, Ethan Sun, Lubna Shah, Jie Xu, Annie Viallat, Emmanuèle Helfer, Zhangli Peng
Physics of Fluids 35:082016 (2023)10.1063/5.0156349
2022
Dynamics of Individual Red Blood Cells Under Shear Flow: A Way to Discriminate Deformability Alterations
Scott Atwell, Catherine Badens, Anne Charrier, Emmanuèle Helfer, Annie Viallat
Frontiers in Physiology 12 (2022)10.3389/fphys.2021.775584
Longitudinal to Transverse Metachronal Wave Transitions in an In Vitro Model of Ciliated Bronchial Epithelium
Olivier Mesdjian, Chenglei Wang, Simon Gsell, Umberto D’ortona, Julien Favier, Annie Viallat, Etienne Loiseau
Physical Review Letters 129:038101 (2022)10.1103/PhysRevLett.129.038101
Lrrcc1 and Ccdc61 are conserved effectors of multiciliated cell function
Aude Nommick, Camille Boutin, Olivier Rosnet, Claire Schirmer, Elsa Bazellières, Virginie Thomé, Etienne Loiseau, Annie Viallat, Laurent Kodjabachian
Journal of Cell Science (2022)10.1242/jcs.258960
2020
Mechanical adaptation of monocytes in model lung capillary networks
Jules Dupire, Pierre-Henri P Puech, Emmanuèle Helfer, Annie Viallat
Proceedings of the National Academy of Sciences of the United States of America 117:14798 (2020)
Hydrodynamic model of directional ciliary-beat organization in human airways
Simon Gsell, Etienne Loiseau, Umberto D’ortona, Annie Viallat, Julien Favier
Scientific Reports 10 (2020)10.1038/s41598-020-64695-w
Active mucus–cilia hydrodynamic coupling drives self-organization of human bronchial epithelium
Etienne Loiseau, Simon Gsell, Aude Nommick, Charline Jomard, Delphine Gras, Pascal Chanez, Umberto D’ortona, Laurent Kodjabachian, Julien Favier, Annie Viallat
Nature Physics (2020)10.1038/s41567-020-0980-z
2019
Self-organization of red blood cell suspensions under confined 2D flows
Cécile Iss, Dorian Midou, Alexis Moreau, Delphine Held, Anne Charrier, Simon Mendez, Annie Viallat, Emmanuèle Helfer
Soft Matter (2019)10.1039/C8SM02571A
2018
Spatiotemporal organization of cilia drives multiscale mucus swirls in model human bronchial epithelium
Mustapha-Kamel Khelloufi, Etienne Loiseau, Marc Jaeger, Nicolas Molinari, Pascal Chanez, Delphine Gras, Annie Viallat
Scientific Reports 8:2447 (2018)10.1038/s41598-018-20882-4
When giant vesicles mimic red blood cell's dynamics: swinging of two-phase vesicles in shear flow
Simon Tusch, Etienne Loiseau, Al-Hair Al-Halifa, Kamel Khelloufi, Emmanuèle Helfer, Annie Viallat
Physical Review Fluids 3 (2018)10.1103/PhysRevFluids.3.123605
2017
High Aspect Ratio Sub-Micrometer Channels Using Wet Etching: Application to the Dynamics of Red Blood Cell Transiting through Biomimetic Splenic Slits
Priya Gambhire, Scott Atwell, Cécile Iss, Frédéric Bedu, Igor Ozerov, Catherine Badens, Emmanuèle Helfer, Annie Viallat, Anne Charrier
Small 13:1700967 (2017)10.1002/smll.201700967
2015
A simple model to understand the effect of membrane shear elasticity and stress-free shape on the motion of red blood cells in shear flow
Jules Dupire, Manouk Abkarian, Annie Viallat
Soft Matter 11:8372-8382 (2015)10.1039/C5SM01407G
Encapsulation of Living Leishmania Promastigotes in Artificial Lipid Vacuoles
Carlos E. S. Guedes, Jose G. B. Lima, Emmanuèle Helfer, Patricia S. T. Veras, Annie Viallat
PLoS ONE 1-12 (2015)10.1371/journal.pone.0134925
Serum Pantetheinase/Vanin Levels Regulate Erythrocyte Homeostasis and Severity of Malaria
Samuel Rommelaere, Virginie Millet, Pascal Rihet, Scott Atwell, Emmanuèle Helfer, Lionel Chasson, Carole Beaumont, Giovanna Chimini, Maria Do Rosario Sambo, Annie Viallat, Carlos Penha-Goncalves, Franck Galland, Philippe Naquet
American Journal of Pathology 185:3039-3052 (2015)10.1016/j.ajpath.2015.07.011
2014
Vesicle adhesion visualized with total internal reflection imaging ellipsometry biosensor
Li Liu, Annie Viallat, Gang Jin
Sensors and Actuators B: Chemical 190:221-226 (2014)
Red blood cell: from its mechanics to its motion in shear flow
A. Viallat, Manouk Abkarian
International Journal of Laboratory Hematology 36:237-243 (2014)10.1111/ijlh.12233
2013
La dynamique des globules rouges sous écoulement
Annie Viallat, Jules Dupire, Marius Socol
Médecine/Sciences 29:468-470 (2013)
2012
Full dynamics of a red blood cell in shear flow
J. Dupire, M. Socol, A. Viallat
Proceedings of the National Academy of Sciences of the United States of America 109:20808-20813 (2012)
Gel Phase Vesicles Buckle into Specific Shapes
François Quemeneur, Catherine Quilliet, Magalie Faivre, Annie Viallat, Brigitte Pepin-Donat
Physical Review Letters 108 (2012)10.1103/physrevlett.108.108303
Gel-phase vesicles buckle into specific shapes
François Quéméneur, Catherine Quilliet, Magalie Faivre, Annie Viallat, Brigitte Pépin-Donat
Physical Review Letters 108:108303 (2012)
2011
Sedimentation of vesicles: from pear-like shapes to microtether extrusion
Huang Zen-Hong, Manouk Abkarian, Annie Viallat
New Journal of Physics 13:035026 (2011)10.1088/1367-2630/13/3/035026
2010
Chaotic Dynamics of Red Blood Cells in a Sinusoidal Flow
Jules Dupire, Manouk Abkarian, Annie Viallat
Physical Review Letters 104:168101 (2010)10.1103/PhysRevLett.104.168101
Sensitive detection of ultra-weak adhesion states of vesicles by interferometric microscopy
Huang Zen-Hong, Gladys Massiera, Laurent Limozin, Paul Boullanger, Valignat Marie-Pierre, Annie Viallat
Soft Matter 6:1948 (2010)10.1039/b925373d
2008
vesicles and red blood cells in shear flow
Manouk Abkarian, Annie Viallat
Soft Matter 4:653 (2008)10.1039/b716612e
Nanotubes from gelly vesicles
Sebastien Kremer, Clément Campillo, Brigitte Pepin-Donat, Annie Viallat, Françoise Brochard-Wyart
EPL - Europhysics Letters 82:48002 (2008)10.1209/0295-5075/82/48002
2007
Swinging of Red Blood Cells under Shear Flow
Manouk Abkarian, Magalie Faivre, Annie Viallat
Physical Review Letters 98 (2007)10.1103/physrevlett.98.188302