Localized Phenomena and Microfluidic

Introduction

AFM probe with a hanging glass fiber, built from a watch quartz tuning fork. The fiber diameter is 5 microns. We build such probes to investigate liquid liquid interfaces at local scale. (electron microscopy)

Publications

2025

Molecular Insights into the Crystallization of 4'-Hydroxyacetophenone from Water: Solute Aggregation, Liquid-Liquid Phase Separation and Polymorph Selection

Carlos E S Bernardes, Ricardo G Simões, M Soledade, C S Santos, Pedro L T Melo, Ângela F S Santos, Stéphane Veesler, Manuel E Minas da Piedade

Crystal Growth & Design (2025)10.1021/acs.cgd.5c00117

The benefit of coupling droplet microfluidics and multiphoton optical microscopy to study the crystallization of polymorphic substances: a case study with ortho -aminobenzoic acid

Hugo Cercel, Clément Brandel, Romain Rac, Clément Pinètre, Charline Gerard, Stéphane Veesler, Nadine Candoni, Romain Grossier, Valérie Dupray

CrystEngComm (2025)10.1039/D4CE01289E

Field ionization intensity used to measure local pressure in gas flows

Felix Sharipov, Irina Martin Graur, Evelyne Salançon

Vacuum 231:113728 (2025)10.1016/j.vacuum.2024.113728

2024

Rapid Polymorphic Screening using Sessile Microdroplets: Competitive Nucleation of Mannitol Polymorphs

Ruel Cedeno, Romain Grossier, Nadine Candoni, Stéphane Veesler

CrystEngComm 26:5235-5240 (2024)10.1039/d4ce00648h

Margination of artificially stiffened red blood cells

Revaz D Chachanidze, Othmane Aouane, Jens Harting, Christian Wagner, Marc Leonetti

Physical Review Fluids 9:L091101 (2024)10.1103/physrevfluids.9.l091101

Assessment of coupled bilayer-cytoskeleton modelling strategy for red blood cell dynamics in flow

V Puthumana, Paul G. Chen, M Leonetti, R Lasserre, Marc Jaeger

Journal of Fluid Mechanics 979:A44 (2024)10.1017/jfm.2023.1092

Drop deformation in a planar elongational flow: impact of surfactant dynamics

Julian Wailliez, Paul Regazzi, Anniina Salonen, Paul G Chen, Marc Jaeger, Marc Leonetti, Emmanuelle Rio

Soft Matter 20:8793-8803 (2024)10.1039/D4SM00642A

2023

Coaxial ion source: Pressure dependence of gas flow and field ion emission

D. Bedrane, A. Houël, A. Delobbe, M. Lagaize, Philippe Dumas, S. Veesler, E. Salançon

Journal of Vacuum Science & Technology B, Nanotechnology and Microelectronics 41 (2023)10.1116/6.0002795

Exploring the World of Membrane Proteins: Techniques and Methods for Understanding Structure, Function, and Dynamics

Imad Boulos, Joy Jabbour, Serena Khoury, Nehme Mikhael, Victoria Tishkova, Nadine Candoni, Hilda E Ghadieh, Stéphane Veesler, Youssef Bassim, Sami Azar, Frédéric Harb

Molecules 28:7176 (2023)10.3390/molecules28207176

Dielectric and Biological Characterization of Liver Tissue in a High-Fat Diet Mouse Model

Clément Buisson, Lourdes Mounien, Flavie Sicard, Jean-François Landrier, Victoria Tishkova, Pierre Sabouroux

Sensors 23:3434 (2023)10.3390/s23073434

CNT effective interfacial energy and pre-exponential kinetic factor from measured NaCl crystal nucleation time distributions in contracting microdroplets

Ruel Cedeno, Romain Grossier, Nadine Candoni, Nicolas Levernier, Adrian Flood, Stéphane Veesler

The Journal of Chemical Physics 158:194705 (2023)10.1063/5.0143704

Microdroplet Approach for Measuring Aqueous Solubility and Nucleation Kinetics of a Metastable Polymorph: The case of KDP Phase IV

Ruel Cedeno, Romain Grossier, Nadine Candoni, Stéphane Veesler

Crystal Growth & Design 23:9052-9057 (2023)10.1021/acs.cgd.3c01086

Breakups of Chitosan microcapsules in extensional flow

Revaz Chachanidze, Kaili Xie, Jinming Lyu, Marc Jaeger, Marc Leonetti

Journal of Colloid and Interface Science 629:445-454 (2023)10.1016/j.jcis.2022.08.169

Modular microfluidic platform for solubility measurement, nucleation statistics and polymorph screening of active pharmaceutical ingredients: Irbesartan, Rimonabant, Aripiprazole and Sulfathiazole

Mathilde Lambert, Romain Grossier, Mehdi Lagaize, Thirou Bactivelane, Vasile Heresanu, Benoît Robert, Nadine Candoni, Stéphane Veesler

Journal of Crystal Growth 616:127252 (2023)

Swirling of vesicles: Shapes and dynamics in Poiseuille flow as a model of RBC microcirculation

Jinming Lyu, Paul G. Chen, Alexander Farutin, Marc Jaeger, Chaouqi Misbah, Marc Leonetti

Physical Review Fluids 8:L021602 (2023)10.1103/PhysRevFluids.8.L021602

New Lidocaine-Based Pharmaceutical Cocrystals: Preparation, Characterization, and Influence of the Racemic vs. Enantiopure Coformer on the Physico-Chemical Properties

Panpan Ma, Balthazar Toussaint, Enrica Angela Roberti, Noémie Scornet, Axel Santos Silva, Luis Castillo Henríquez, Monique Cadasse, Philippe Négrier, Stéphane Massip, Hanh Dufat, Karim Hammad, Cecilia Baraldi, Maria Cristina Gamberini, Cyrille Richard, Stéphane Veesler, Philippe Espeau, Tu Lee, Yohann Corvis

Pharmaceutics 15:1102 (2023)10.3390/pharmaceutics15041102

Mechanical characterization of core-shell microcapsules

Kaili Xie, Marc Leonetti

Comptes Rendus. Mécanique 351:1-20 (2023)10.5802/crmeca.148

2022

Evaporation Dynamics of Sessile Saline Microdroplets in Oil

Ruel Cedeno, Romain Grossier, Victoria Tishkova, Nadine Candoni, Adrian E. Flood, Stéphane Veesler

Langmuir 38:9686-9696 (2022)10.1021/acs.langmuir.2c01269

Nucleation in Sessile Saline Microdroplets: Induction Time Measurement via Deliquescence-Recrystallization Cycling

Ruel Cedeno, Romain A Grossier, Mehdi Lagaize, D. Nerini, Nadine Candoni, A. E. Flood, Stéphane Veesler

Faraday Discussions 183-197 (2022)10.1039/D1FD00090J

Structural characterization of the interfacial self-assembly of chitosan with oppositely charged surfactant

Revaz Chachanidze, Kaili Xie, Hanna Massaad, Denis C.D. Roux, Marc Léonetti, Clément de Loubens

Journal of Colloid and Interface Science 616:911-920 (2022)10.1016/j.jcis.2022.01.143

Bright sources under the projection microscope: using an insulating crystal on a conductor as electron source

L Lapena, D Bedrane, A Degiovanni, E. Salançon

European Physical Journal: Applied Physics (2022)

Low-macroscopic field emission structure: Using the shape of the conductor to identify a local difference in electric potential

L Lapena, A Degiovanni, V Tishkova, E. Salançon

Journal of Vacuum Science and Technology (2022)

2021

First microwave tomography approach towards a truly noninvasive, pain-free and wearable blood glucose monitoring device

Asma Bakkali, Clément Buisson, Lourdes Mounien, Jean François Landrier, Victoria Tishkova, Pierre Sabouroux

Progress In Electromagnetics Research M 102:193-206 (2021)10.2528/PIERM21032803

Dynamics of pearling instability in polymersomes: the role of shear membrane viscosity and spontaneous curvature

J Lyu, K Xie, R Chachanidze, A Kahli, Gwenn Boedec, Marc Leonetti

Physics of Fluids 33:122016 (2021)10.1063/5.0075266

An isogeometric boundary element method for soft particles flowing in microfluidic channels

Jinming Lyu, Paul G. Chen, G. Boedec, M. Leonetti, Marc Jaeger

Computers and Fluids 214:104786 (2021)10.1016/j.compfluid.2020.104786

Impaired adhesion of neutrophils expressing Slc44a2/HNA-3b to VWF protects against NETosis under venous shear rates

Gaïa Zirka, Philippe Robert, Julia Tilburg, Victoria Tishkova, Chrissta Maracle, Paulette Legendre, Bart van Vlijmen, Marie-Christine Alessi, Peter Lenting, Pierre-Emmanuel Morange, Grace Thomas

Blood 137:2256-2266 (2021)10.1182/blood.2020008345