Properso Veesler

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    CRYSTALLIZATION FROM SOLUTION

    Stéphane VEESLER (E-mail)

    Directeur de recherche au CNRS (section 05)
    Recherche au sein du département Sources et Sondes Ponctuelles

    Crystallization is a solid-liquid interfacial process aimed at obtaining solid particles and purifying a product.
    In industrial crystallization studies, we work on the relationship between the properties of crystallized materials (down-stream processes and properties of materials) and their crystallization conditions.
    We develop an original fundamental approach to crystallization enabling us to reach the objectives defined with industrial or academic partners. We study the impact of crystallization parameters, such as supersaturation, temperature (Download), additives/impurities, hydrodynamics, etc., on crystal habit, morphology, crystal size distribution, phase transitions (polymorphism and demixion). (Download : Polymorphism in processes of crystallisation in solution: a practical review) (Download :Impact of Liquid-Liquid Phase Separation on Drug Crystallization)

    In structural biology, the atomic-scale protein 3D-structure is required to determine the relationship between this structure and the biological activity. This is valuable, for instance, in drug design. Protein crystallization is a difficult and time-consuming step in the structure determination process.
    (Download) Using Temperature To Crystallize Proteins: A Mini-Review
    (Download : Protein Crystallization: Contribution of Small-Angle X-ray Scattering (SAXS))

    More... (some papers) :

     

    Observation by optical microscopy of crystallization in confined system : high supersaturation, nucleation and growth are ultra-rapid and 1 crystal per droplet

    		Protein crystal of lysozyme obtained in localized electric field . In situ 10X10µm2 solution-AFM image showing a double screw dislocation on a (001) face of alpha-amylase crystal. (step height=50 Å).