Département IMMF

Molecular Engineering and Functional Materials

Leader: Jean-Manuel Raimundo


The IMMF research activities are at the crossroad of chemistry-physics-biology and focus mainly on the synthesis, physicochemical characterization and properties of organic, inorganic and / or hybrid molecular structures for energy, health, environment, information and communication.

These themes are structured in three main research axes that are molecular materials for photonics, molecular materials for electronics and nanomedicine with a global multidisciplinary approach (syntheses - development of nanostructured materials - characterizations), leading to the development of devices whose properties fulfill the major societal concerns.

The IMMF department has a strong knowledge and has developed a solid expertise in molecular and supramolecular chemistry that enables it to synthesize and characterize nanostructures based in particular on pi-conjugated aromatic and heteroaromatic molecules, amphiphilic, glycosidic and chiral molecules.

In this context, the molecular engineering of several original families of chromophores has been developed responding to scientific and technological issues at the forefront of current concerns.

The department is also involved in the synthesis of inorganic or hybrid nanoparticles for applications in the energy field, or organic nanoparticles and dendrimers for applications in personalized medicine and care.

A particular effort is also made to deposit, growth, self-organization of nanostructures in solution and toward the functionalization of substrates for the development of functional materials.

Équipe Fages



Theoretical insight on PTB7:PC 71 BM, PTB7-th:PC 71 BM and Si-PCPDTBT:PC 71 BM interactions governing blend nanoscale morphology for efficient solar cells

Claudia Caddeo, Alessio Filippetti, Andrea Bosin, Christine Videlot-Ackermann, Jörg Ackermann, Alessandro Mattoni

Nano Energy (2021)


Direct Observations of the Structural Properties of Semiconducting Polymer: Fullerene Blends under Tensile Stretching

Mouaad Yassine Aliouat, Dmitriy Ksenzov, Stéphanie Escoubas, Jörg Ackermann, Dominique Thiaudière, Cristian Mocuta, Mohamed Cherif Benoudia, David Duche, Olivier Thomas, Souren Grigorian

Materials 13:3092 (2020)10.3390/ma13143092

In situ measurements of the structure and strain of a π-conjugated semiconducting polymer under mechanical load

Mouaad Yassine Aliouat, Stephanie Escoubas, Mohamed Chérif Benoudia, Dmitriy Ksenzov, David Duché, Evangéline Bènevent, Christine Videlot-Ackermann, Jörg Ackermann, Olivier Thomas, Souren Grigorian

Journal of Applied Physics 127:045108 (2020)10.1063/1.5127226

Organic-Inorganic doped Nickel Oxide Nanocrystals for Hole Transport Layers in Inverted Polymer Solar Cells with Color Tuning

Riva Alkarsifi, Yatzil Alejandra Avalos-Quiroz, Pavlo Perkhun, Xianjie Liu, Mats Fahlman, Anil Kumar Bharwal, Carmen M. Ruiz, David Duché, Jean-Jacques Simon, Christine Videlot-Ackermann, Olivier Margeat, Jörg Ackermann

Materials Chemistry Frontiers (2020)

Electrical molecular switch addressed by chemical stimuli.

Hassib Audi, Yannick Viero, N Alwhaibi, Zhongrui Chen, Maksym Iazykov, Arnaud Heynderickx, Fan Xiao, David Guérin, Christophe Krzeminski, Iain Mark Grace, Colin Lambert, Olivier Siri, Dominique Vuillaume, Stéphane Lenfant, H.R. Klein

Nanoscale (2020)10.1039/D0NR02461A

Direct correlation of nanoscale morphology and device performance to study photocurrent generation in donor enriched phases of polymer solar cells

Sadok Ben Dkhil, Pavlo Perkhun, Chieh Luo, David Müller, Riva Alkarsifi, Elena Barulina, Yatzil Alejandra Avalos-Quiroz, Olivier Margeat, Stephan Thierry Dubas, Tomoyuki Koganezawa, Daiki Kuzuhara, Noriyuki Yoshimoto, Claudia Caddeo, Alessandro Mattoni, Birger Zimmermann, Uli Würfel, Martin Pfannmöller, Sara Bals, Jörg Ackermann, Christine Videlot-Ackermann

ACS Applied Materials & Interfaces (2020)10.1021/acsami.0c05884

Robust transparent conducting electrode based on silver nanowire coating on polyelectrolytes multilayers

Jedsada Chavalitkul, Olivier Margeat, Jörg Ackermann, Stephan Dubas

Thin Solid Films 711:138272 (2020)10.1016/j.tsf.2020.138272

Synthesis and use of an amphiphilic dendrimer for siRNA delivery into primary immune cells

Jiaxuan Chen, Aleksandra Ellert-Miklaszewska, Stefano Garofalo, Arindam Dey, Jingjie Tang, Yifan Jiang, Flora Clément, Patrice Marche, Xiaoxuan Liu, Bozena Kaminska, Angela Santoni, Cristina Limatola, John Rossi, Jiehua Zhou, Ling Peng

Nature Protocols (2020)10.1038/s41596-020-00418-9

Unconventional access to a solvatochromic nickel (II) dye featuring a coordination-induced spin crossover behavior

Zhongrui Chen, Khrouz Lhoussain, Christophe Bucher, Denis Jacquemin, Dominique Luneau, Olivier Siri

Dyes and Pigments 183:108645 (2020)10.1016/j.dyepig.2020.108645

An ionizable supramolecular dendrimer nanosystem for effective siRNA delivery with a favorable safety profile

Dinesh Dhumal, Wenjun Lan, Ling Ding, Yifan Jiang, Zhenbin Lyu, Erik Laurini, Domenico Marson, Aura Tintaru, Nelson Dusetti, Suzanne Giorgio, Juan Lucio Iovanna, Sabrina Pricl, Ling Peng

Nano Research (2020)10.1007/s12274-020-3216-8

Surface Charge of Supramolecular Nanosystems for In Vivo Biodistribution: A MicroSPECT/CT Imaging Study

Ling Ding, Zhenbin Lyu, Beatrice Louis, Aura Tintaru, Erik Laurini, Domenico Marson, Mengjie Zhang, Wanxuan Shao, Yifan Jiang, Ahlem Bouhlel, Laure Balasse, Philippe Garrigue, Eric Mas, Suzanne Giorgio, Juan Iovanna, Yuanyu Huang, Sabrina Pricl, Benjamin Guillet, Ling Peng

Small 16:301-304 (2020)10.1002/smll.202003290

Natural killer cells modulate motor neuron-immune cell cross talk in models of Amyotrophic Lateral Sclerosis

Stefano Garofalo, Germana Cocozza, Alessandra Porzia, Maurizio Inghilleri, Marcello Raspa, Ferdinando Scavizzi, Eleonora Aronica, Giovanni Bernardini, Ling Peng, Richard Ransohoff, Angela Santoni, Cristina Limatola

Nature Communications 11:1773 (2020)10.1038/s41467-020-15644-8

Therapeutic siRNA: state of the art

Bo Hu, Liping Zhong, Yuhua Weng, Ling Peng, Yuanyu Huang, Yongxiang Zhao, Xing-Jie Liang

Signal Transduction and Targeted Therapy 5 (2020)10.1038/s41392-020-0207-x

Liver Activation of Hepatocellular Nuclear Factor-4α by Small Activating RNA Rescues Dyslipidemia and Improves Metabolic Profile

Kai-Wen Huang, Vikash Reebye, Katherine Czysz, Simona Ciriello, Stephanie Dorman, Isabella Reccia, Hong-Shiee Lai, Ling Peng, Nikos Kostomitsopoulos, Joanna Nicholls, Robert Habib, Donald Tomalia, Pål Sætrom, Edmund Wilkes, Pedro Cutillas, John Rossi, Nagy Habib

Molecular Therapy - Nucleic Acids 19:361-370 (2020)10.1016/j.omtn.2019.10.044

Visualizing morphological principles for efficient photocurrent generation in organic non-fullerene acceptor blends

Wolfgang Köntges, Pavlo Perkhun, Jochen Kammerer, Riva Alkarsifi, Uli Würfel, Olivier Margeat, Christine Videlot-Ackermann, Jean-Jacques Simon, Rasmus Schröder, Jörg Ackermann, Martin Pfannmöller

Energy & Environmental Science 13 (2020)10.1039/c9ee03535d

Targeting NUPR1 with the small compound ZZW-115 is an efficient strategy to treat hepatocellular carcinoma

Wenjun Lan, Patricia Santofimia-Castaño, Yi Xia, Zhengwei Zhou, Can Huang, Nicolas Fraunhoffer, Dolores Barea, Melchiore Cervello, Lydia Giannitrapani, Giuseppe Montalto, Ling Peng, Juan Iovanna

Cancer Letters 486:8-17 (2020)10.1016/j.canlet.2020.04.024

ZZW-115-dependent inhibition of NUPR1 nuclear translocation sensitizes cancer cells to genotoxic agents

Wenjun Lan, Patricia Santofimia-Castaño, Mirna Swayden, Yi Xia, Zhengwei Zhou, Stéphane Audebert, Luc Camoin, Can Huang, Ling Peng, Ana Jiménez-Alesanco, Adrián Velázquez-Campoy, Olga Abián, Gwen Lomberk, Raul Urrutia, Bruno Rizzuti, Vincent Geli, Philippe Soubeyran, José Neira, Juan Iovanna

JCI Insight 5 (2020)10.1172/jci.insight.138117

Mixed N-Aryl/Alkyl Substitution Favours an Unusual Tautomer of Near-Infrared Absorbing Azacalixphyrins

Lucien Lavaud, Cloé Azarias, Gabriel Canard, Simon Pascal, Denis Jacquemin, Olivier Siri

New Journal of Chemistry (2020)10.1039/D0NJ04587J

Optical spin-dependent beam separation in cyclic group symmetric metasurface

Yeon Ui Lee, Igor Ozerov, Frédéric Bedu, Ji Su Kim, Frédéric Fages, Jeong Weon Wu

Nanophotonics 9:3459-3471 (2020)10.1515/nanoph-2020-0160

Near-Infrared Electrochemiluminescence in Water through Regioselective Sulfonation of Diaza [4] and [6]helicene Dyes

Haidong Li, Romain Duwald, Simon Pascal, Silvia Voci, Céline Besnard, Johann Bosson, Laurent Bouffier, Jérôme Lacour, Neso Sojic

Chemical Communications (2020)10.1039/D0CC04156D

Stabilization of a 12-π electrons diamino-benzoquinonediimine tautomer

Jean-François Longevial, Zhongrui Chen, Simon Pascal, Gabriel Canard, Denis Jacquemin, Olivier Siri

Chemical Communications (2020)10.1039/D0CC06815B

Access to Fluorenones Using Benzocyclopentynone Surrogate as Partner for the [2 + 2 + 2] Cycloaddition Reaction

Anne-Doriane Manick, Bruno Salgues, Jean-Luc Parrain, Elena Zaborova, Frédéric Fages, Muriel Amatore, Laurent Commeiras

Organic Letters 22:1894-1898 (2020)10.1021/acs.orglett.0c00235

Synthesis, Resolution, Configurational Stability, and Properties of Cationic Functionalized [5]Helicenes

Maya Marinova, Simon Pascal, Laure Guénée, Céline Besnard, Boris Shivachev, Kalina Kostova, Claudio Villani, Roberta Franzini, Vladimir Dimitrov, Jérôme Lacour

Journal of Organic Chemistry (2020)10.1021/acs.joc.0c01716

Impacts of Ion‐Pairing Effects on Linear and Nonlinear Photophysical Properties of Polymethines Dyes

Simon Pascal, San-Hui Chi, Joseph Perry, Chantal Andraud, Olivier Maury, S.-H Chi

ChemPhysChem (2020)10.1002/cphc.202000731

Rectifying antennas for energy harvesting from the microwaves to visible light: A review

C.A. Reynaud, David Duché, Jean-Jacques Simon, Estéban Sanchez-Adaime, O. Margeat, Jörg Ackermann, Vikas Jangid, Chrystelle Lebouin, Damien Brunel, Frederic Dumur, Didier Gigmes, Gérard Berginc, C.A. Nijhuis, Ludovic Escoubas

Progress in Quantum Electronics 72:100265 (2020)10.1016/j.pquantelec.2020.100265

Small Panchromatic and NIR Absorbers from Quinoid Zwitterions

Angélina Torres Ruiz, Manon Bousquet, Simon Pascal, Gabriel Canard, Valérie Mazan, Mourad Elhabiri, Denis Jacquemin, Olivier Siri

Organic Letters (2020)10.1021/acs.orglett.0c02926

1D Coordination π‐d Conjugated Polymers with Distinct Structures Defined by the Choice of the Transition Metal: Towards a New Class of Antiaromatic Macrocycles

Vijai Meena Santhini, Christian Wäckerlin, Ales Cahlik, Martin Ondráček, Simon Pascal, Adam Matěj, Oleksandr Stetsovych, Pingo Mutombo, Petr Lazar, Olivier Siri, Pavel Jelinek

Angewandte Chemie International Edition (2020)10.1002/anie.202011462

Long-standing Optically-excited Magnetic States in ZnO Nanoparticles

Adrien Savoyant, Clément Sebastiao, Olivier Margeat

physica status solidi (RRL) - Rapid Research Letters (2020)10.1002/pssr.202000176

Novel Aryltriazole Acyclic C-Azanucleosides as Anticancer Candidates

Yanhua Zhang, Yun Lin, Qianqian Hou, Xi Liu, Sabrina Pricl, Ling Peng, Yi Xia

Organic and Biomolecular Chemistry (2020)10.1039/d0ob02164d

Novel triazole nucleoside analogues promote anticancer activity via both apoptosis and autophagy

Yanhua Zhang, Xi Liu, Yun Lin, Baoping Lian, Wenjun Lan, Juan Iovanna, Xiaoxuan Liu, Ling Peng, Yi Xia

Chemical Communications 56:10014-10017 (2020)10.1039/d0cc04660d


  • 06/02/2019: Elena Barulina & Jonathan Phelipot

  • 13/02/2019: Yatzil Avalos & Bruno Salgues

  • 20/02/2019: Jiaxuan Chen & Pavlo Perkhun

  • 27/02/2019: Angélina Torres Ruiz & Frédéric Brunel

  • 06/03/2019: Sanjana Auditto & Wenjun Lan

  • 13/03/2019: Riva Alkarsifi & Dinesh Dumal

  • 20/03/2019: Zhenbin Lyu & Manon Catherin

  • 27/03/2019: Yifan Jiang & Ling Ding

  • 10/04/2019: Yi-Wen Yao & Yatzil Avalos

  • 17/04/2019: Elena Barulina & Bruno Salgues

  • 24/04/2019: Jiaxuan Chen

  • 15/05/2019: Angélina Torres Ruiz

  • 22/05/2019: Sanjana Auditto & Jonathan Phelipot

  • 29/05/2019: Manon Catherin & Dinesh Dumal

  • 26/06/2019: Riva Alkarsifi & Pavlo Perkhun

  • 03/07/2019: Serena Carrara & Frédéric Brunel

  • 10/07/2019: Ling Ding & Yi-Wen Yao

  • 17/07/2019: Yifan Jiang & Zhenbin Lyu


Équipe Ackermann 1 Sources et sondes ponctuelles 2 Physique et nano-micro Ingénierie pour le Vivant 1 Équipe Peng Équipe Peng 1

  • ANR contracts

  • 1 Doc2AMU fellowship

  • 1 collaboration contract with Dracula Technologie company

  • 1 AMidex project

  • 1 "Ligue contre le Cancer" labeled team

  • 2 Horizon 2020 contracts