Department IMMF

Molecular Engineering and Functional Materials

Leader: Olivier Margeat

Introduction

The research activities of the "Molecular Engineering and Functional Materials" department (IMMF) stand at the interface of chemistry-physics-biology and focus on the synthesis, the physico-chemical characterization and the property studies of organic, inorganic and/or hybrid molecular structures.

These activities are divided around three research themes:

 


Nanomedicine
Biomaterials

 

  • Vectorization

 

  • Bioimaging / Diagnostic

 

  • Therapy

 


Singular conjugated
structures

 

  • Engineering of chromophores and fluorophores

 

  • Molecular switches

 

  • Supramolecular chemistry

 


Surfaces, thin films
& devices

 

  • Assemblies on surface

 

  • Functional coatings

 

  • Optoelectronic devices

 

Publications

2025

Dynamic switching of ferrocene and plasmonic interactions in Au/self-assembled monolayer/single Ag nanocube molecular junctions

Mariem Ben Youssef, Peeranuch Poungsripong, Hugo Bidotti, Halidou Abdoul-Yasset, Didier Gigmes, Olivier Margeat, Beniamino Sciacca, Judikaël Le Rouzo, David Duché, Dominique Vuillaume

The Journal of Physical Chemistry C (2025)10.1021/acs.jpcc.4c07890

Advanced delivery systems for gene editing: A comprehensive review from the GenE-HumDi COST Action Working Group

Alessia Cavazza, Francisco J Molina-Estévez, Álvaro Plaza Reyes, Victor Ronco, Asma Naseem, Špela Malenšek, Peter Pečan, Annalisa Santini, Paula Heredia, Araceli Aguilar-González, Houria Boulaiz, Qianqian Ni, Marina Cortijo-Gutierrez, Kristina Pavlovic, Inmaculada Herrera, Berta de la Cerda, Emilio M Garcia-Tenorio, Eva Richard, Sergio Granados-Principal, Arístides López-Márquez, Mariana Köber, Marijana Stojanovic, Melita Vidaković, Irene Santos-Garcia, Lorea Blázquez, Emily Haughton, Dongnan Yan, Rosario María Sánchez-Martín, Loubna Mazini, Gloria Gonzalez Aseguinolaza, Annarita Miccio, Paula Rio, Lourdes R Desviat, Manuel a F V Gonçalves, Ling Peng, Cecilia Jiménez-Mallebrera, Francisco Martin Molina, Dhanu Gupta, Duško Lainšček, Yonglun Luo, Karim Benabdellah

Molecular Therapy - Nucleic Acids 36:102457 (2025)10.1016/j.omtn.2025.102457

Curcuminoid Derivatives with a Donor‐Acceptor‐Donor Architecture: an Outstanding Platform for Highly‐Efficient Near‐Infrared Electroluminescence and Amplified Spontaneous Emission

Anthony d'Aléo, Xun Tang, Dae‐hyeon Kim, Danillo Valverde, Elena Zaborova, Gabriel Canard, Arnaud Brosseau, Loic Mager, Gilles Clavier, Chihaya Adachi, Yoann Olivier, Jean-Charles Ribierre

Advanced Optical Materials (2025)10.1002/adom.202500338

Amphiphilic dendrimer-assisted delivery of antisense nucleic acid mimics against E. coli

Mariana Gomes, Igor Resende, Yana Zamoshchak, Daniela Araújo, Joana Castro, Dinesh Dhumal, Ling Peng, Rita S Santos, Nuno F Azevedo

Journal of Controlled Release 384:113850 (2025)10.1016/j.jconrel.2025.113850

Synthesis of tetranuclear cyclopalladated complex using thiosemicarbazone derivative ligand: Spectral, biological and molecular docking studies

Zohreh Mehri Lighvan, Azar Ramezanpour, Sara Pirani, Ali Akbari, Maryam Dehdashti Jahromi, Anthony Kermagoret, Abolfazl Heydari

Journal of Molecular Structure 1321:139932 (2025)10.1016/j.molstruc.2024.139932

Self-assembling dendrimer nanodrug formulations for decreased hERG-related toxicity and enhanced therapeutic efficacy

Xi Liu, Dinesh Dhumal, Patricia Santofimia-Castaño, Juan Liu, Marion Casanova, Alicia Comino Garcia-Muñoz, Teodora-Adriana Perles-Barbacaru, Abdechakour Elkihel, Wenzheng Zhang, Tom Roussel, Christina Galanakou, Jing Wu, Eleni Zerva, Nelson Dusetti, Yi Xia, Xing-Jie Liang, Angèle Viola, Juan Iovanna, Ling Peng

Science Advances 11 (2025)10.1126/sciadv.adu9948

P-cadherin mechanoactivates tumor-mesothelium metabolic coupling to promote ovarian cancer metastasis

Jing Ma, Sally Kit Yan To, Katie Sze Wai Fung, Kun Wang, Jiangwen Zhang, Alfonso Hing Wan Ngan, Susan Yung, Tak Mao Chan, Carmen Chak Lui Wong, Philip Pun Ching Ip, Ling Peng, Hong-Yan Guo, Chi Bun Chan, Alice Sze Tsai Wong

Cell Reports 44:115096 (2025)10.1016/j.celrep.2024.115096

Synthesis and Properties of Quinoidal (Di-)Anionic Coupled Polymethine-Oxonol Dyes and Their Aromatic Counterparts

Benjamin Mourot, Carmelo Naim, Olivier Siri, Denis Jacquemin, Simon Pascal

Organic Chemistry Frontiers (2025)10.1039/D5QO00801H

Small far-red cationic benzoquinone diimine dyes

Tatiana Munteanu, Carmelo Naim, Gabriel Canard, Denis Jacquemin, Olivier Siri, Simon Pascal

Organic & Biomolecular Chemistry (2025)10.1039/D5OB00082C

Metastable Macrocyclic Bis‐Meisenheimer Adduct

Simon Pascal, Angélina Torres Ruiz, Aerin Baker, Douglas Vander Griend, Michel Giorgi, Aurélien Planchat, Denis Jacquemin, Olivier Siri

Angewandte Chemie International Edition (2025)10.1002/anie.202511037

Unlocking the Gates: A Novel Diagnostic Molecule for Quantifying Efflux Levels in Gram‐Positive Bacteria

Mrunal Patil, Tatiana Munteanu, Gaël Brasseur, Carolina Ferreira, Sofia Santos Costa, Isabel Couto, Mohd Athar, Elisa Asunis, Attilio Vittorio Vargiu, Miguel Viveiros, Carole Digiorgio, Frédéric Brunel, Jean‐manuel Raimundo, Michel Camplo, Olivier Siri, Jean‐michel Bolla

Advanced Healthcare Materials 14:2404145 (2025)10.1002/adhm.202404145

Impact of inner hydrophobicity of dendrimer nanomicelles on biodistribution: a PET imaging study

Tom Roussel, Twiany Cruz-Dubois, Beatrice Louis, Erik Laurini, Ling Ding, Laure Balasse, Vincent Nail, Françoise Dignat‐george, Suzanne Giorgio, Sabrina Pricl, Benjamin Guillet, Philippe Garrigue, Ling Peng

Journal of materials chemistry‎ B 13 (2025)10.1039/D4TB01266F

Bola-Amphiphilic Dendrimer Enhances Imatinib to Target Metastatic Ovarian Cancer via β-Catenin-HRP2 Signaling Axis

Zeyu Shi, Margarita Artemenko, Weiyu Yu, Ming Zhang, Canhui Yi, Peng Chen, Shuting Lin, Zhancun Bian, Baoping Lian, Fanzhen Meng, Jiaxuan Chen, Tom Roussel, Ying Li, Karen K L Chan, Philip P C Ip, Hung-Cheng Lai, Sally K Y To, Xiaoxuan Liu, Ling Peng, Alice S T Wong

ACS Applied Materials & Interfaces (2025)10.1021/acsami.4c12857

Transamination of Zwitterionic Quinones with Polyamines: The Carbon Bridge Matters

Vlad Tarpa, Jean-François Longevial, Michel Giorgi, Gabriel Canard, Simon Pascal, Denis Jacquemin, Olivier Siri

Journal of Organic Chemistry 90:1001-1005 (2025)10.1021/acs.joc.4c02100

On-surface gold-catalyzed hydroamination/cyclization reaction of alkynes

Bruno de La Torre, Alejandro Jiménez-Martín, Tatiana Munteanu, Qifan Chen, Simon Pascal, Benjamin Mallada, Pingo Mutombo, Olivier Siri, Pavel Jelínek

Materials Chemistry Frontiers (2025)10.1039/D4QM00866A

Molecular Stiffening by Macrocycle Clustering

Hang Yin, Qian Cheng, Roselyne Rosas, Stéphane Viel, Valerie Monnier, Laurence Charles, Didier Siri, Didier Gigmes, Mehdi Yemloul, Ruibing Wang, Anthony Kermagoret, David Bardelang

Angewandte Chemie International Edition 64 (2025)10.1002/anie.202420880

STING‐Activating Polymers Boost Lymphatic Delivery of mRNA Vaccine to Potentiate Cancer Immunotherapy

Miao Zhang, Yongling Wang, Benhao Li, Bowei Yang, Mengyao Zhao, Bingyu Li, Jianping Liu, Yaxin Hu, Zhaoming Wu, Yenhui Ong, Xiaolin Han, Lingwen Ding, Kongfu Zhu, Jianwei Li, Min Luo, Shengqi Chen, Ling Peng, Longjiang Zhang, Xiaoyuan Chen, Qianqian Ni

Advanced Materials (2025)10.1002/adma.202412654

2024

Between hope and reality: treatment of genetic diseases through nucleic acid-based drugs

Virginie Baylot, Thi Khanh Le, David Taïeb, Palma Rocchi, Laurence Colleaux

Communications Biology 7:489 (2024)10.1038/s42003-024-06121-9

Correlation between materials and band‐selective detection in organic photodetectors based on bulk heterojunction

Quentin Eynaud, Anass Khodr, Mohamed El Amine Kramdi, Gilles Quéléver, Olivier Margeat, Jörg Ackermann, Christine Videlot-Ackermann

Journal of Applied Polymer Science (2024)10.1002/app.55481

Self-assembling dendrimer nanosystems for specific fluorine magnetic resonance imaging and effective theranostic treatment of tumors

Zhenbin Lyu, Brigino Ralahy, Teodora-Adriana Perles-Barbacaru, Ling Ding, Yifan Jiang, Baoping Lian, Tom Roussel, Xi Liu, Christina Galanakou, Erik Laurini, Aura Tintaru, Suzanne Giorgio, Sabrina Pricl, Xiaoxuan Liu, Monique Bernard, Juan Iovanna, Angèle Viola, Ling Peng

Proceedings of the National Academy of Sciences of the United States of America 121:e2322403121 (2024)10.1073/pnas.2322403121

Coupled Polymethine Dyes: Six Decades of Discoveries

Benjamin Mourot, Denis Jacquemin, Olivier Siri, Simon Pascal

Chemical Record e202400183 (2024)10.1002/tcr.202400183

Feasibility of Multiple Excited-State Proton Transfer Processes in Hydroxyquinoline-containing Benzobisimidazole Dyes

Tatiana Munteanu, Dancho Yordanov, Gabriel Canard, Olivier Siri, Denis Jacquemin, Anton Georgiev, Simon Pascal

New Journal of Chemistry 48:13289-13295 (2024)10.1039/D4NJ01787K

Post-functionalization of triamino-phenazinium dyes to reach near-infrared emission

Tatiana Munteanu, Jean-François Longevial, Gabriel Canard, Denis Jacquemin, Simon Pascal, Olivier Siri

RSC Advances 14:19257-19263 (2024)10.1039/D4RA03245D

High-Order Commensurate Zwitterionic Quinonoid Phase Induces a Nanoscale Dipole Lattice on Graphene

Gaelle Nassar, Diego Cortés-Arriagada, Luis Sanhueza-Vega, Périne Landois, Matthieu Paillet, Haitham Hrich, Sylvie Contreras, Olivier Siri, Simon Pascal, Laurence Masson, Conrad Becker, Alain Ranguis, Romain Parret, Gabriel Canard, Thomas Leoni

Journal of Physical Chemistry C 128:9712-9721 (2024)10.1021/acs.jpcc.4c01695

Insights into the relationship between molecular and order-dependent photostability of ITIC derivatives for the production of photochemically stable blends

Y. Quiroz Avalos, Quentin Eynaud, Pavlo Perkhun, Agnès Rivaton, Wolfgang Köntges, Rasmus R Schröder, Tomoyuki Koganezawa, Noriyuki Yoshimoto, A. Kumar Bharwal, David Duché, Carmen M M Ruiz, Olivier Margeat, Cyril Aumaitre, Renaud Demadrille, Christine Videlot-Ackermann, Jörg Ackermann

Journal of Materials Chemistry C (2024)10.1039/D3TC04614A

Insight into the Internal Structure of High-Performance Multicore Magnetic Nanoparticles Used in Cancer Thermotherapy

Tom Roussel, Daniel Ferry, Artemis Kosta, Dalila Miele, Giuseppina Sandri, Felista Tansi-Lemnyui, Frank Steiniger, Paul Southern, Quentin Pankhurst, Ling Peng, Suzanne Giorgio

ACS Materials Au (2024)

Bis‐Indeno‐Fused Tetraazaanthracene Hybrids: Straightforward Synthesis and Studies of Optical and Electronic Properties

Bruno Salgues, Rudraditya Sarkar, Nans Potier, Anne-Doriane Manick, Gabriel Canard, Jean-Luc Parrain, Michel Giorgi, Nicolas Vanthuyne, Christine Videlot-Ackermann, Jörg Ackermann, Fréderic Fagès, Boris Le Guennic, Denis Jacquemin, Muriel Amatore, Elena Zaborova, Laurent Commeiras

European Journal of Organic Chemistry e202400719 (2024)10.1002/ejoc.202400719

Designer metasurfaces via nanocube assembly at the air-water interface

Beniamino Sciacca, Muhammad L. Fajri, Nicolas Kossowski, Ibtissem Bouanane, F. Bedu, Peeranuch Poungsripong, Renato Juliano-Martins, Clement Majorel, Olivier Margeat, Judikaël Le Rouzo, Patrice Genevet

ACS Nano 18 (2024)10.1021/acsnano.4c06022

Electrocatalytic Properties of meso ‐ Perfluorinated Metallo Corroles for the Reduction of CO 2

Chanjuan Zhang, Paul‐gabriel Julliard, Diana Dragoe, Ally Aukauloo, Gabriel Canard

European Journal of Inorganic Chemistry 27:e202400318 (2024)10.1002/ejic.202400318

Targeting the phosphatidylglycerol lipid: An amphiphilic dendrimer as a promising antibacterial candidate

Nian Zhang, Dinesh Dhumal, Shanny Hsuan Kuo, Shi Qian Lew, Pankaj Patil, Raleb Taher, Sanika Vaidya, Christina Galanakou, Abdechakour Elkihel, Myung Whan Oh, Sook Yin Chong, Domenico Marson, Jun Zheng, Oleg Rouvinski, Williams Abolarin, Sabrina Pricl, Gee Lau, Leo Tsz On Lee, Ling Peng

Science Advances 10:eadn8117 (2024)10.1126/sciadv.adn8117

Financement

Équipe Ackermann 1 Sources et sondes ponctuelles 2 Physique et nano-micro Ingénierie pour le Vivant 1 Équipe Peng Équipe Peng 1

  • ANR contracts

  • 1 Doc2AMU fellowship

  • 1 collaboration contract with Dracula Technologie company

  • 1 AMidex project

  • 1 "Ligue contre le Cancer" labeled team

  • 2 Horizon 2020 contracts