Properso Veesler
CRYSTALLIZATION FROM SOLUTION
Stéphane VEESLER (E-mail)
Directeur de recherche au CNRS (section 05)Recherche au sein du département Sources et Sondes Ponctuelles
Topics
Physics - Chemistry - Biology InterfaceCrystallization is a solid-liquid interfacial process aimed at obtaining solid particles and purifying a product. In industrial crystallization studies, we work on the relationship between the properties of crystallized materials (down-stream processes and properties of materials) and their crystallization conditions.
- In structural biology, the atomic-scale protein 3D-structure is required to determine the relationship between this structure and the biological activity. This is valuable, for instance, in drug design. Protein crystallization is a difficult and time-consuming step in the structure determination process.
- We develop an original fundamental approach to crystallization enabling us to reach the objectives defined with industrial or academic partners.
Understanding and controlling Nucléation are one of the major focus of our work. Because nucleation is a stochastic phenomenon a spatial and temporal control of nucleation will enable us to explore the formation and the structure of critical nuclei and to unravel the mechanisms of nucleation.
- Development of New Methods for In situ Study of Solution-Crystallization - Polymorphism – Liquid-Liquid Phase Separation - Industrial Processes – End-Use Properties.
At this moment
1. Usual and Non-Usual Approach of Crystallization: (Download)Usual approach: We study the impact of crystallization parameters, such as supersaturation, temperature, additives/impurities, hydrodynamics, etc., on crystal habit, morphology, crystal size distribution, phase transitions (polymorphism and demixion).
Non-usual approach: Research of crystallization conditions using external field: localized voltage(Download), ultrasounds, photochemical induced nucleation (Download)...
Microfluidics for Crystallization CGD , JCG, OPRD , CGD 2013 , OPRD2015, Hydrodynamics, Microfluidic platform , microfluidique and X-ray , Protein-ligand crystallization
Do the differing properties of materials influence their nucleation mechanisms? We present different experimental approaches to study and control nucleation, and shed light on some of the factors affecting the nucleation process. Faraday Discussions , PRL
2. Confinement : Thermodynamic (model): (Download) , the setup : (Download)and kinetic (experiments): (Download)
Crystallization in confined system gives new opportunities to study crystallization processes ( Phases Stabilized in Confined Nano- and Picovolumes)
Monitor, control and understand nucleation-frequency and nucleation-location:(Download) and data treatment (AIP)
3. Molecular Interactions, Structuration, Association and Biomolecule Crystallization
Fundamentals of association, nucleation, crystal growth of complex systems (globular proteins, membrane proteins, active pharmaceutical ingredients...) by a physico-chemical approach
(Crystallization) (interaction and phase separation)
[ 4. Elaboration and manipulation of materials with high added value
A microfluidic device is developed to produce monodisperse transparent particles with controllable sizes and mechanical and aggregation properties that will mimic Red Blood Cells for biomedical applications.
(Article)
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